Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

Balusamy, Brabu; Anitha, S.; Uyar, Tamer

doi:10.15671/hjbc.789186

Cited by 7 publications

(2 citation statements)

References 128 publications

(163 reference statements)

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“…In electrospinning, a jet is created by applying a high voltage over a polymer solution/emulsion to create an intense electric field on a droplet at the tip of a needle. The jets are then collected on a metal collector and the dried electrospun materials can be used for many purposes such as wound healing, drug delivery system and tissue engineering applications [1,2].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Controlling Morphology of Polyethylene Oxide/Sodium Alginate Beads and/or Fibers: Effect of Viscosity and Conductivity in Electrospinning

Böncü

2023

Ankara Ecz. Fak. Derg.

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Objective: The aim of the study is to determine the viscosity and conductivity of PEO/NaAlg polymer solutions, to formulate PEO/NaAlg beads, bead-on-string fibers and fibers via electrospinning, and to perform advanced morphological characterization studies on them. Material and Method: Effect of PEO and NaAlg concentration and ratio of them on spinnability, viscosity and conductivity of solutions, and also on the morphological properties of PEO/NaAlg electrospun fibers, and beads (length, width and aspect ratio of beads, number of beads and bead area) were investigated. Result and Discussion: As a result, electrospun materials were produced using PEO/NaAlg beads and/or fibers, which are valuable for medical and biological applications such as tissue engineering, wound dressing, drug delivery system. Viscosity and conductivity of solutions, and morphological properties of the obtained materials were found to be affected by PEO and NaAlg concentration and the ratio of them. Spinnability was improved thanks to the increase in conductivity in the presence of PEO. The lower viscosity and conductivity resulted in the production of beads that were generally smaller and greater in number in the material and having higher area. The morphological properties of PEO/NaAlg electrospun materials can be modified by controlling the parameters examined in the study.

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Section: Introductionmentioning

confidence: 99%

Fabrication and Controlling Morphology of Polyethylene Oxide/Sodium Alginate Beads and/or Fibers: Effect of Viscosity and Conductivity in Electrospinning

Böncü

2023

Ankara Ecz. Fak. Derg.

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“…Electrospun materials have unique properties, making them excellent candidates for biomedical applications such as tissue engineering [ 1 , 2 , 3 ], wound dressings [ 4 , 5 , 6 , 7 , 8 ] and drug delivery vehicles [ 9 , 10 ]. The large surface-to-volume ratio and high porosity combined with small pore sizes improve breathability, impenetrability to bacteria and contamination, as well as fluid absorptivity, which, combined with the incorporation of medicinal substances, enables the development of active wound dressing, accelerating the healing process [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Parametric Finite Element Model and Mechanical Characterisation of Electrospun Materials for Biomedical Applications

et al. 2021

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Electrospun materials, due to their unique properties, have found many applications in the biomedical field. Exploiting their porous nanofibrous structure, they are often used as scaffolds in tissue engineering which closely resemble a native cellular environment. The structural and mechanical properties of the substrates need to be carefully optimised to mimic cues used by the extracellular matrix to guide cells’ behaviour and improve existing scaffolds. Optimisation of these parameters is enabled by using the finite element model of electrospun structures proposed in this study. First, a fully parametric three-dimensional microscopic model of electrospun material with a random fibrous network was developed. Experimental results were obtained by testing electrospun poly(ethylene) oxide materials. Parameters of single fibres were determined by atomic force microscopy nanoindentations and used as input data for the model. The validation was performed by comparing model output data with tensile test results obtained for electrospun mats. We performed extensive analysis of model parameters correlations to understand the crucial factors and enable extrapolation of a simplified model. We found good agreement between the simulation and the experimental data. The proposed model is a potent tool in the optimisation of electrospun structures and scaffolds for enhanced regenerative therapies.

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Fabrication of Textile-Based Scaffolds Using Electrospun Nanofibers for Biomedical Applications

Ashok

Babu

Kavitha

et al. 2022

Advances in Polymer Science

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Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

Cited by 7 publications

References 128 publications

Fabrication and Controlling Morphology of Polyethylene Oxide/Sodium Alginate Beads and/or Fibers: Effect of Viscosity and Conductivity in Electrospinning

Fabrication and Controlling Morphology of Polyethylene Oxide/Sodium Alginate Beads and/or Fibers: Effect of Viscosity and Conductivity in Electrospinning

Parametric Finite Element Model and Mechanical Characterisation of Electrospun Materials for Biomedical Applications

Fabrication of Textile-Based Scaffolds Using Electrospun Nanofibers for Biomedical Applications

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