2021
DOI: 10.3390/molecules26061598
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In Vivo Biological Behavior of Polymer Scaffolds of Natural Origin in the Bone Repair Process

Abstract: Autologous bone grafts, used mainly in extensive bone loss, are considered the gold standard treatment in regenerative medicine, but still have limitations mainly in relation to the amount of bone available, donor area, morbidity and creation of additional surgical area. This fact encourages tissue engineering in relation to the need to develop new biomaterials, from sources other than the individual himself. Therefore, the present study aimed to investigate the effects of an elastin and collagen matrix on the… Show more

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Cited by 7 publications
(9 citation statements)
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References 41 publications
(53 reference statements)
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“…In this scenario, and in the face of critical bone defects, the use of biomaterials has gained space in pre-clinical research [ 8 , 9 ]. An ideal bone substitute must present important characteristics such as the release of growth factors that enhance bone neoformation, promote a framework, and favor a microenvironment that enhances tissue growth [ 10 ].…”
Section: Introductionmentioning
confidence: 99%
“…In this scenario, and in the face of critical bone defects, the use of biomaterials has gained space in pre-clinical research [ 8 , 9 ]. An ideal bone substitute must present important characteristics such as the release of growth factors that enhance bone neoformation, promote a framework, and favor a microenvironment that enhances tissue growth [ 10 ].…”
Section: Introductionmentioning
confidence: 99%
“…Notably, the quality and preservation of the tissues in the surgical area and adjacent to it observed upon macroscopic inspection, in the absence of clinical signs of infectious processes and/or necrosis in soft or bone tissue, indicate the biocompatibility of the biomaterials [ 32 , 45 ]. This fact was observed in all groups receiving the extracellular matrix implants (G2 to G4 and G6 to G8).…”
Section: Discussionmentioning
confidence: 99%
“…The collagen matrix was derived from bovine intestinal serosa and the elastin matrix from bovine auricular cartilage. The manufacturing process of matrices and their characterizations have been described in detail in previously published studies [ 16 , 27 , 28 , 29 , 30 , 31 , 32 ]. In summary, the bovine serosa and auricular cartilage were washed exhaustively in 0.9% saline (NaCl) and distilled water.…”
Section: Methodsmentioning
confidence: 99%
“…In addition, chitosan exhibits the essential characteristics for a scaffold material since it is nontoxic and exerts antimicrobial activity 28 30 . In view of its properties and three-dimensional structure, this natural polymer has been used in experimental studies of bone reconstruction, which demonstrated its biocompatibility and biodegradability 7 , 31 , as well as important osteoconductive properties 11 , 30 .…”
Section: Introductionmentioning
confidence: 99%
“…Tissue engineering has been developing scaffolds that enable cell adhesion and proliferation 5,6 . Among these scaffolds, there are polymers that, due to their threedimensional structures and characteristics similar to biological tissues, have the ability to allow cell growth 7 .In vitro studies using collagen scaffolds have confirmed the suitability of polymers for bone reconstruction 8,9 , as well as for the regeneration of bone defects created experimentally in rats 10,11 . The advantages of collagen include properties such as biocompatibility, biodegradability, and cell interaction capacity 12 .…”
mentioning
confidence: 99%