2022
DOI: 10.3390/polym14102075
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Effects of a Biocomplex Formed by Two Scaffold Biomaterials, Hydroxyapatite/Tricalcium Phosphate Ceramic and Fibrin Biopolymer, with Photobiomodulation, on Bone Repair

Abstract: There are several treatment methods available for bone repair, although the effectiveness becomes limited in cases of large defects. The objective of this pre-clinical protocol was to evaluate the grafting of hydroxyapatite/tricalcium phosphate (BCP) ceramic biomaterial (B; QualyBone BCP®, QualyLive, Amadora, Portugal) together with the heterologous fibrin biopolymer (FB; CEVAP/UNESP Botucatu, Brazil) and with photobiomodulation (PBM; Laserpulse®, Ibramed, Amparo, Brazil) in the repair process of bone defects.… Show more

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Cited by 16 publications
(16 citation statements)
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References 69 publications
(91 reference statements)
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“…The laser procedure was based on our previously established protocols [ 28 ]. They are in good agreement with the data in the literature [ 29 , 30 ].Our objective was to assess the effects of low-level laser therapy on fluoridation. We chose the bio-modulation mode of the diode laser (specific for gingival tissue) and explored the way it influences the fluoridation of hard dental tissues, when applied after the calcium fluoride forming agent.…”
Section: Methodssupporting
confidence: 92%
“…The laser procedure was based on our previously established protocols [ 28 ]. They are in good agreement with the data in the literature [ 29 , 30 ].Our objective was to assess the effects of low-level laser therapy on fluoridation. We chose the bio-modulation mode of the diode laser (specific for gingival tissue) and explored the way it influences the fluoridation of hard dental tissues, when applied after the calcium fluoride forming agent.…”
Section: Methodssupporting
confidence: 92%
“…This bioproduct (HFS) is composed of a thrombin-like enzyme purified from the venom of Crotalus durissus terrificus snake and a cryoprecipitate rich in fibrinogen extracted from Bubalus bubalis buffaloes (produced by CEVAP/UNESP—Center for the Study of Venoms and Venomous Animals, Botucatu, Brazil). HFS has several advantages in its use, such as a fast production process, low cost, potential to act as a scaffold for stem cells [ 69 , 70 , 71 ] and biomaterials [ 50 , 72 ], and as a new drug delivery system [ 73 ]. Its indications are in medical, veterinary and dental practice, due to the possibility of personalized formulation and replacement of conventional sutures.…”
Section: Discussionmentioning
confidence: 99%
“…Our team of researchers has used a laser photobiomodulation protocol in the bone defects repair process, which has achieved satisfactory and promising results [ 23 , 24 , 25 , 26 , 27 , 28 ]. However, a new approach to treatment frequency has been required for future research due to greater convenience, and to the need to be financially viable, allowing for the use of this technique in clinical practice.…”
Section: Introductionmentioning
confidence: 99%