2023
DOI: 10.1038/s41598-022-24424-x
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Collagen-chitosan-hydroxyapatite composite scaffolds for bone repair in ovariectomized rats

Abstract: Lesions with bone loss may require autologous grafts, which are considered the gold standard; however, natural or synthetic biomaterials are alternatives that can be used in clinical situations that require support for bone neoformation. Collagen and hydroxyapatite have been used for bone repair based on the concept of biomimetics, which can be combined with chitosan, forming a scaffold for cell adhesion and growth. However, osteoporosis caused by gonadal hormone deficiency can thus compromise the expected res… Show more

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Cited by 15 publications
(11 citation statements)
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“…In addition, the gel formation of these derivatives gives them the ability to create structures based on natural polymers that resemble extracellular matrices with indications for tissue regeneration [ 60 ]. In addition, the literature also demonstrates the osteogenic action of collagen and elastin scaffolds [ 23 , 34 ] and some phytochemical compounds derived from plants such as flavonoids, tannins, polyphenols, anthocyanins, terpenoids, polysaccharides, and alkaloids due to their properties as antioxidants, anti-inflammatories, and bone signaling pathway modulators [ 17 ]. The results obtained in this study were compared with data from other researchers, and some important differences and similarities were observed, but there were still some doubts about the ideal structure of biomaterials used in bone reconstruction, especially in the mandible.…”
Section: Resultsmentioning
confidence: 99%
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“…In addition, the gel formation of these derivatives gives them the ability to create structures based on natural polymers that resemble extracellular matrices with indications for tissue regeneration [ 60 ]. In addition, the literature also demonstrates the osteogenic action of collagen and elastin scaffolds [ 23 , 34 ] and some phytochemical compounds derived from plants such as flavonoids, tannins, polyphenols, anthocyanins, terpenoids, polysaccharides, and alkaloids due to their properties as antioxidants, anti-inflammatories, and bone signaling pathway modulators [ 17 ]. The results obtained in this study were compared with data from other researchers, and some important differences and similarities were observed, but there were still some doubts about the ideal structure of biomaterials used in bone reconstruction, especially in the mandible.…”
Section: Resultsmentioning
confidence: 99%
“…Based on this comparative information on mandibular continuity reconstruction methods, surgeons can choose a single technique or a combination of techniques, and associate them with alternative biomaterials that have demonstrated osteogenic capacity through experimental research in the field of tissue engineering [ 21 , 22 , 23 , 24 ]. These include natural polymers such as collagen, which mimic the extracellular matrix of bone and can also be combined with anti-inflammatory and antioxidant substances found in some plants [ 25 ].…”
Section: Introductionmentioning
confidence: 99%
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“…It is important to mention the enzymatic degradation of chitosan and chitosan-based therapeutic systems, being resorbable in situ for medical applications. At the same time, chitosan presents other degradation mechanisms, such as oxidation with H 2 O 2 , acid hydrolysis with HCl, ultrasonic irradiation, where 1–4 bonds can be broken in the amorphous fields, and also by applying heat or microwave. , This most important derivative of chitin is a versatile biopolymer showing biocompatibility, nontoxicity, and antibacterial and antifungal properties. , That is why it is used in several biomedical applications: wound healing, encapsulation of sensitive drugs, drug delivery, and scaffolds for nerve tissue regeneration. Chuc-Gamboa et al compared the effects on biocompatibility of two scaffolds based on chitosan crosslinked with polyethylene glycol diglycidyl ether (PEGDE) and glutaraldehyde (GA). PEGDE-crosslinked chitosan showed a reduction in free amino groups and in the amide I/II ratio, indicating that PEGDE used in low concentrations is a biocompatible crosslinker for chitosan, and therefore, these materials can be used in bone regeneration applications.…”
Section: Introductionmentioning
confidence: 99%
“…Due to the shortage of donors worldwide [6] and the threat of infection [7], autograft and allograft are not practical options for bone substitutes. Abundantly available and environmentally friendly hydroxyapatite has biological similarities to bone tissue [8][9][10][11], making it an attractive option for hard tissue engineering and biomedical engineering research [12]. Waste from animals, for instance mammalian bone [13][14][15], fish bones and scales [16][17][18], and shells [19][20][21], can be used to extract hydroxyapatite and develop artificial bone substitutes.…”
Section: Introductionmentioning
confidence: 99%