“…It is important to mention the enzymatic degradation of chitosan and chitosan-based therapeutic systems, being resorbable in situ for medical applications. At the same time, chitosan presents other degradation mechanisms, such as oxidation with H 2 O 2 , acid hydrolysis with HCl, ultrasonic irradiation, where 1–4 bonds can be broken in the amorphous fields, and also by applying heat or microwave. , This most important derivative of chitin is a versatile biopolymer showing biocompatibility, nontoxicity, and antibacterial and antifungal properties. , That is why it is used in several biomedical applications: wound healing, encapsulation of sensitive drugs, drug delivery, and scaffolds for nerve tissue regeneration. − Chuc-Gamboa et al compared the effects on biocompatibility of two scaffolds based on chitosan crosslinked with polyethylene glycol diglycidyl ether (PEGDE) and glutaraldehyde (GA). PEGDE-crosslinked chitosan showed a reduction in free amino groups and in the amide I/II ratio, indicating that PEGDE used in low concentrations is a biocompatible crosslinker for chitosan, and therefore, these materials can be used in bone regeneration applications.…”