In vivo antioxidant and UV-photoprotective of extract pasak bumi (Eurycoma Longifolia Jack.)

Edyson,; Pardede, Angga Maulana Edward; Nugraha, Hardiandy Gilbert; Mashuri,; Suhartono, Eko

doi:10.1063/1.5110004

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…Alkaloid has a role as scavenger of superoxide radical. The activ-ity of antioxidant and SOD enzymes would increase but superoxide anion level decrease (Edyson et al, 2019).…”

Section: Antioxidant Activitymentioning

confidence: 99%

A review of the phytochemical compounds and pharmacological activities of Eurycoma longifolia

Insanu¹,

Pratiwi²,

Fidrianny³

2021

ijrps

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Eurycoma longifolia belongs to Simaroubaceae family. It is a tall tree and has different local name from many countries and this review consisted of their traditional usage, phytochemical compounds and pharmacological activity. A systematic review was conducted to study the scientific work of E. longifolia which published in the last 10 years and minimum 20 articles that published in the last 2 years, published in Pubmed, Scopus etc. also has a digital object identifier (DOI). E. longifolia was a popular traditional medicine. The leaves wasused as supplement for giving birth, its bark as anthelmintic and its roots as antimalaria, laxative, antidiabetic etc.Due to high demand of this plant there are various formula of E. longifolia available in health food market. Many studies have been performed to determine the active constituents and pharmacology activities of E. longifolia. Alkaloid, quassinoid, polyphenols, flavonoid, polysaccharide, triterpenoid were found in E. longifolia. Quassinoids is a major phytochemical compound in E. longifolia which has various types like eurycumanone, eurycomanol, eurycomadilactone and eurylactone. Quassinoids has bitter taste and often found in Simaroubaceae family.Pharmacological activities of E. longifolia such as anti-inflammatory, analgesic, antioxidant, antimicrobial, antidiabetic, anti-osteoporotic activities. The literature review results showed that E. longifolia can be considered as medicinal plant for human. In the future, further studies on mechanism of pharmacology activity of E. longifolia are warranted.

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“…Alkaloid has a role as scavenger of superoxide radical. The activ-ity of antioxidant and SOD enzymes would increase but superoxide anion level decrease (Edyson et al, 2019).…”

Section: Antioxidant Activitymentioning

confidence: 99%

A review of the phytochemical compounds and pharmacological activities of Eurycoma longifolia

Insanu¹,

Pratiwi²,

Fidrianny³

2021

ijrps

View full text Add to dashboard Cite

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“…In addition, the pasak bumi (Eurycoma Longifolia Jack.) plant and Dayak onion (Eleutherine palmifolia (L.) merr) are also used as antioxidants and photoprotective [4][5].…”

Section: Introductionmentioning

confidence: 99%

Molecular docking studies of 4-ethyl-2-metoxyphenol and 1,3-cyclopentanedione compounds from gemor (Nothaphoebe coriacea) with glucagon like-peptide-1 (GLP-1) receptor

Suhartono

Biworo

Santosa³

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

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Gemor (Nothaphoebe coriacea) is a plant that grows in wetland forests. Many studies have revealed the potential of this plant for health and medicine, among others as an antioxidant, anti-inflammatory, antidiabetic, and others. However, the mechanism is unknown or not yet discovered. Previous studies have shown that gemor bark contains active compounds. One of them is 4-ethyl-2-metoxyphenol (PubChem ID 62465) and 1,3-cyclo pentanedione (PubChem CID 77466) compounds. This research will prove that 2 compounds act as antidiabetic by influencing Glucagon like-Peptide-1 (GLP-1) Receptor. Molecular docking was carried out on 2 these compounds. The protein is taken from RCSB PDB (4ZGM). Ligand and protein preparation, analyzed and visualized docking results were carried out with the Chimera 1.14. Molecular docking using SWISSDOCK. The results show that the 4-ethyl-2-methoxyphenol compound can be bound by 6 residues (SER 84, CYS 85, TRP 87, ALA 92, VAL 95, and Pro 96); 1,3-cyclopentanedione bind by 7 residues (GLY 45, CYS 46, TYR 42, SER 49, CYS 71, VAL 83 and PRO 73). Gibbs energy for 4-Ethyl-2-methoxyphenol and 1,3-Cyclopentanedione, against GLP-1 Receptor each -6.10 kcal/mol and -5.37 kcal/mol. The conclusion is that 4-Ethyl-2-methoxyphenol and 1,3-Cyclopentanedione compound has the potential as an antidiabetic by binding mechanism with residues of GLP-1 receptor.

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“…3,4 Many studies are currently being conducted on plants with antioxidant properties, such as gemor, kelakai, bawang dayak, pasak bumi, and others. [5][6][7][8][9][10][11] Many earlier researches have noted that nigella sativa (NS) is a plant that acts as an antioxidant. The administration of 500 mg/day of nigella sativa to rats exposed to cigarette acid was found to reduce serum oxidative damage (Table 1).…”

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confidence: 99%

Supplementation of Nigella sativa as Antioxidant in COVID-19 Patients: In silico Study via the Nrf2-Keap1 Pathway

Oktaviyanti¹,

Nurrasyidah²,

Muthmainah³

et al. 2022

IJDDT

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In vivo antioxidant and UV-photoprotective of extract pasak bumi (Eurycoma Longifolia Jack.)

Cited by 5 publications

References 11 publications

A review of the phytochemical compounds and pharmacological activities of Eurycoma longifolia

A review of the phytochemical compounds and pharmacological activities of Eurycoma longifolia

Molecular docking studies of 4-ethyl-2-metoxyphenol and 1,3-cyclopentanedione compounds from gemor (Nothaphoebe coriacea) with glucagon like-peptide-1 (GLP-1) receptor

Supplementation of Nigella sativa as Antioxidant in COVID-19 Patients: In silico Study via the Nrf2-Keap1 Pathway

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