In Vitro Susceptibility Test of Different Clinical Isolates against Ceftriaxone

Masood, Syed Hakim; Aslam, Nousheen

doi:10.5001/omj.2010.56

Cited by 20 publications

(13 citation statements)

References 18 publications

(18 reference statements)

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“…Among all brands, B6 showed higher activity against E. coli , S. aureus and Pseudomonas aueresinosa ; B1 showed higher activity against S. typhi . The study conducted in Pakistan by Masood and Aslam showed clinical isolates were resistant to ceftriaxone [8]. Similarly, the study conducted at Nepal with three ceftriaxone brands showed only six isolates were resistant against Brand C tested, but the other A and B were susceptible against all isolates [9].…”

Section: Discussionmentioning

confidence: 94%

“…resistant to ceftriaxone. [8] Similarly, the study conducted at Nepal with three ceftriaxone brands showed only six isolates were resistant against Brand C tested, but the other A and B were susceptible against all isolates. [9] Humza studied the in-vitro comparative efficacy of various antibiotics against P. aeruginosa; results reveal that ceftriaxone has no sensitivity.…”

Section: Discussionmentioning

confidence: 95%

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Comparative efficacy evaluation of seven commercial injectable ceftriaxone purchased at Ambo, Oromia Regional State, Ethiopia, using agar well plate diffusion method

Gunasekaran

Desta

Seifu

et al. 2015

Journal of Pharmaceutical Health Services Research

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Background Irrational use of this drug leads to emergence of resistant bacteria and also leads to infections that are worse than the original diagnosed ones. Important concern is the uncertainty of administered antibiotics about whether the quality of a generic medicine is equal to brand name drug; if both brand/generic are bioequivalent, then antibiotic selection should be based on the cost of therapy. Methods The efficacy of seven ceftriaxone brands available at Ambo, Oromia Regional State, Ethiopia, was evaluated by microwell plate diffusion technique against four different bacteria. Results All brands of two concentrations were showed sufficient inhibitory activity against four microorganisms, so they should all be considered as bioequivalence. Among all brands tested, B6 showed higher activity against Escherichia coli American Type Culture Collection (ATCC) 10536, Staphylococcus aureus ATCC 29737 and Pseudomonas aeruginosa ATCC 25619, and B1 showed higher activity against Salmonella typhi ATCC 06775. Interestingly, the concentration C2 (50 μg/ml) of B1-B7 showed equivalent zone of inhibition to that of the standard. ConclusionWe conclude that performance of tested ceftriaxone injectable products were equivalent to the standard. We recommend that the physicians may select the ceftriaxone brand which is low cost in order to reduce the cost of treatment.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 95%

Comparative efficacy evaluation of seven commercial injectable ceftriaxone purchased at Ambo, Oromia Regional State, Ethiopia, using agar well plate diffusion method

Gunasekaran

Desta

Seifu

et al. 2015

Journal of Pharmaceutical Health Services Research

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“…The antibiotic policy guidelines preparation is the need to avoid any bitter experience of misuse of this class of drug therapy, the team efforts of the members comprising consultants, prescribing physicians, and members of health services team should participate in producing an effective plan to make better decisions in this regards (Masood, 2010). In addition, surveillance programs should be conducted periodically to evaluate the sensitivity and susceptibility of these bacteria against prescribed antibiotics.…”

Section: P Aeruginosa Isolated From Various Clinical Samplesmentioning

confidence: 99%

“…Since the emergence of resistance remains silent for some periods and takes time to become apparent, these antibiotics should be prescribed with cautions so that the bitter experience of antibiotic resistance can be avoided (Jombo et al, 2010). These in vitro sensitivity studies also help in cost-effective; prescribing different brands of the antibiotic to the different patients with varying socioeconomic back-grounds (Masood, 2010). Overall, resistance patterns in different regions should be conducted so that the profiles of the specific region are maintained and monitored accordingly.…”

Section: P Aeruginosa Isolated From Various Clinical Samplesmentioning

confidence: 99%

Antimicrobial resistance pattern of clinical isolate of Pseudomonas aeruginosa in the University of Malaya Medical Center, Malaysia

Al-Kabsi¹,

Yusof²,

Sekaran³

2011

Afr. J. Microbiol. Res.

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Pseudomonas aeruginosa is considered as one of the leading causes of nosocomial infections. The start of antimicrobial therapy is often empirical and selective pressure on panel of antibiotics; therefore, it is important to know the susceptibility pattern of pathogens in order to select the most appropriate antibiotic. The aim of the current study is to update the rational empirical antimicrobial therapy recommendations. Antimicrobial resistance was done using the E-test method. Urine and wound swab samples were the highest encountered isolates; results were interpreted according to National Committee for Clinical Laboratory Standards guidelines. A total of 88 clinical isolates of P. aeruginosa were collected randomly from April 2009 to March 2010 from the University of Malaya Medical Center. P. aeruginosa isolated from various clinical samples has lost susceptibility and showed increasing resistance to Gentamicin with 94.3%, followed by (ciprofloxacin) 92%, (ceftazidime) 89.8%, (imipenem) 73.9%, Pipracilline/tazobactam 61.4%, (aztreonam) 52.3%, and (amikacin) 50% and only susceptible to colistin with 92%. In conclusion, most of the isolates showed high levels of resistance to examined antibiotics except colistin and this may indicate the importance of antibiotic susceptibility testing and optimal treatment by combination of drugs.

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“…This study will help physicians, clinicians and consultants to decide its use in the most appropriate clinical infections. Microbial drug resistance is an unavoidable outcome of the use of antimicrobial agents [6]. The present study identified the various non-fermenters by staining techniques.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Identification of Multi-Drug Resistant Strains of Non-Lactose Fermenting Bacteria from Clinical Refuses in Major Hospitals of Khyber Pakhtunkhwa, Pakistan

Zahid¹,

Akbar²,

Sthanadar³

et al. 2014

OJMM

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Purpose: The present studied was performed in order to investigate the drug resistance of different non-lactose fermenting gram negative bacteria from clinical isolates. The bacteria were morphologically characterized through culturing and gram staining techniques were used for the identification of different bacterial strains. Methods: A total of 324 samples were collected from patients, after they were diagnosed by physicians at different hospitals at district Peshawar. Samples were morphologically identified by blood agar, MacConkey agar and Eosine Methylene Blue, identified by gram staining techniques. Modified Kirby-Bauer Disc diffusion method was used to test the in-vitro susceptibility of the identified isolates to different antibiotics. Results: The nonlactose fermenting gram negative bacteria were isolated from samples of blood (33.30%), pus/ wound (33.30%), urine (23.30%) and from ascetic/pleural fluids (10.20%). The study revealed that Pseudomonas aeroginosa showed high resistance against Gentamicin (74%) and Aztreonam (74%), followed by Ciprofloxacin (59.20%) and Amikacin (33.30). Tazocin was active as low resistance (18.50%) is shown. More resistance was seen in Morganella morganii against Aztreonam (77.7%) followed by Gentamicin (62.90%), Ciprofloxacin (40.70%). Tazocin show low resistance * Corresponding author. M. Zahid et al. 125(3.70%). Multidrug resistant Proteus mirabillis was highly resistance to Gentamicin (66.60%), followed by Aztreonam (62.90%), Amikacin (55.50%), Ciprofloxacin (40.20%) and low resistance to Tazocin was (22.20%). Salmonella typhi demonstrated high resistance against Amikacin (62.90%), followed by Aztreonam (48.10%), Tazocin (40.70%). Gentamicin showed low resistance (29.60%), and hence it is more active against S. typhi. Conclusions: It can be concluded from the present study that different species of non-lactose fermenting gram negative bacteria have shown a different resistivity pattern. This study is a gate way for better and suitable management strategy for the infections caused by non-Lactose fermenting bacteria in the sampling region.

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In Vitro Susceptibility Test of Different Clinical Isolates against Ceftriaxone

Abstract: Ceftriaxone can be used as a drug of choice in infections caused by S. aureus, E. coli, P. aurigenosa, K. pneumonia and S. typhi. However, it should be used with other antimicrobial agents in order to increase its effectiveness against P. mirabilis.

Cited by 20 publications

References 18 publications

Comparative efficacy evaluation of seven commercial injectable ceftriaxone purchased at Ambo, Oromia Regional State, Ethiopia, using agar well plate diffusion method

Comparative efficacy evaluation of seven commercial injectable ceftriaxone purchased at Ambo, Oromia Regional State, Ethiopia, using agar well plate diffusion method

Antimicrobial resistance pattern of clinical isolate of Pseudomonas aeruginosa in the University of Malaya Medical Center, Malaysia

Isolation and Identification of Multi-Drug Resistant Strains of Non-Lactose Fermenting Bacteria from Clinical Refuses in Major Hospitals of Khyber Pakhtunkhwa, Pakistan

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