In vitro skin irritation: facts and future. State of the art review of mechanisms and models

Welss, Thomas; Basketter, David A.; Schröder, Klaus R.

doi:10.1016/j.tiv.2003.09.009

Cited by 264 publications

(154 citation statements)

References 94 publications

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“…It is accepted that chemical irritants may cause skin irritation via two distinct pathways; impairment of the barrier function of the stratum corneum and/or by direct effects on the cells of the keratin ocytes of the epidermal layer (Kartono and Maibach, 2006;Welss et al, 2004;Wilhelm et al, 1993). Chatterjee et al (2005) found that application of benzene to hairless rat skin result in skin irritation, and increase inflammatory cytokines released from inflammatory cells.…”

Section: Advances In Pharmaceutical Andmentioning

confidence: 99%

Ameliorating Effect of Achillea fragrantissima Against Benzene-Induced Skin Irritation: Histological Study

Al-Shathly¹,

Alqahtani²

2017

Adv. Pharm. Ethnomed

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| Organic solvents such as car fuel, which contains benzene and other solvents were known to cause skin irritation and contact dermatitis. Although anti-inflammatory steroids topical medications were used, they may result in side effects in susceptible persons. Herbal preparation was tried in literature. In the present study, Achillea fragrantissima, a wild plant in some areas of Saudi Arabia was used to speed slow-healing wounds. Thus, the study was designed to investigate its efficacy to treat experimentally induced benzene-dermatitis in mice skin. Twenty-five adult mice were shaved and animals were divided into GI as control and GII as benzene painted. The later was further divided into four subgroups; untreated, steroidal medicinal cream treated, a group treated with olive oil extract of Achillea (dried plant soaked in olive oil) and a group treated with olive oil only. Gross and histopathological observation were used to evaluate the treatment effects. Benzene painting produced skin hardening, scaling, epidermal hyperplasia and inflammatory reaction in skin dermis. Decrease in the hypodermal adipose tissue thickness was observed, those pathological changes were much improved or even absent in treated mice. Such results are similar to that observed in the group treated by medicinal cream. Achillea plant could be a source of future effective anti-dermatitis cream medicinal formulation against benzene-induced dermatitis. Olive oil extract of Achillea will be tested and compared to olive oil alone to prove the hypothesis.

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Section: Advances In Pharmaceutical Andmentioning

confidence: 99%

Ameliorating Effect of Achillea fragrantissima Against Benzene-Induced Skin Irritation: Histological Study

Al-Shathly¹,

Alqahtani²

2017

Adv. Pharm. Ethnomed

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“…Nanoparticles in skin cells cause cytotoxicity characterized by induction of ROS 340 and the release of inflammatory factors. 341,342 This damage may lead to dermal irritation 343 and skin sensitization. 344 The exposure of skin cells to silver nanoparticles and SWCNTs caused ultrastructural and morphological changes in the cells 345 and increased the expression of IL-6, 315,334 the cytokine responsible for mediating dermal irritation.…”

Section: View Article Onlinementioning

confidence: 99%

Perturbation of physiological systems by nanoparticles

et al. 2014

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Nanotechnology is having a tremendous impact on our society. However, societal concerns about human safety under nanoparticle exposure may derail the broad application of this promising technology. Nanoparticles may enter the human body via various routes, including respiratory pathways, the digestive tract, skin contact, intravenous injection, and implantation. After absorption, nanoparticles are carried to distal organs by the bloodstream and the lymphatic system. During this process, they interact with biological molecules and perturb physiological systems. Although some ingested or absorbed nanoparticles are eliminated, others remain in the body for a long time. The human body is composed of multiple systems that work together to maintain physiological homeostasis. The unexpected invasion of these systems by nanoparticles disturbs normal cell signaling, impairs cell and organ functions, and may even cause pathological disorders. This review examines the comprehensive health risks of exposure to nanoparticles by discussing how nanoparticles perturb various physiological systems as revealed by animal studies. The potential toxicity of nanoparticles to each physiological system and the implications of disrupting the balance among systems are emphasized.

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“…IL-8, a pro-inflamatory and chemotactic cytokine is a key mediator of UVB-induced inflammation, acting as a potent chemoattractant for neutrophils, which then cause local tissue damage [40]. Furthermore, IL-8 induces keratinocyte proliferation, angiogenesis and growth of a variety of tumors and enhances expression of matrix metalloproteinases (MMPs) [41,42].…”

Section: 5mentioning

confidence: 99%

Photoprotection by Punica granatum seed oil nanoemulsion entrapping polyphenol-rich ethyl acetate fraction against UVB-induced DNA damage in human keratinocyte (HaCaT) cell line

Baccarin

Mitjans

Ramos³

et al. 2015

Journal of Photochemistry and Photobiology B: Biology

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In vitro skin irritation: facts and future. State of the art review of mechanisms and models

Cited by 264 publications

References 94 publications

Ameliorating Effect of Achillea fragrantissima Against Benzene-Induced Skin Irritation: Histological Study

Ameliorating Effect of Achillea fragrantissima Against Benzene-Induced Skin Irritation: Histological Study

Perturbation of physiological systems by nanoparticles

Photoprotection by Punica granatum seed oil nanoemulsion entrapping polyphenol-rich ethyl acetate fraction against UVB-induced DNA damage in human keratinocyte (HaCaT) cell line

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