In vitro Permeation Study of Ketoprofen Patch with Combination of Ethylcellulose and Polyvynil Pyrrolidone as Matrix Polymers

Mita, Soraya Ratnawulan; Husni, Patihul; Setiyowati, Dewi

doi:10.5530/jyp.2018.2s.20

Cited by 6 publications

(3 citation statements)

References 14 publications

(17 reference statements)

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“…The resulting solution was poured into patch molds made of glass measuring 5 x 5 cm. The solvent was allowed to evaporate at room temperature for 24 hours (Mita et al, 2018). The variations in the concentrations of PVP K 30, ethyl cellulose, and menthol can be seen in Table 1.…”

Section: Formulation Of Film Patch Diclofenac Potassiummentioning

confidence: 99%

Optimization of Diclofenac Potassium Transdermal Patch Formula Using a Combination of Polyvynil Pyrrolidone K 30, Ethyl Cellulose and Menthol With Simplex Lattice Design Method

Gunawan,

Supriyadi,

Kuncahyo

2024

JFSP

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Diclofenac potassium is one of the NSAID drugs which can cause gastrointestinal irritation and damage to the small intestinal mucosa including erosion and ulceration. The purpose of this study was to determine the effect of the combination of PVP K 30, ethyl cellulose and menthol on organoleptic, thickness, weight uniformity, moisture and folding resistance of diclofenac potassium transdermal patch.This research is an experimental study that includes an experiment to optimize the formulation of a transdermal patch preparation with the active ingredient potassium diclofenac and a combination of PVP K 30, ethyl cellulose and menthol. The optimization method uses the simplex lattice design method. There are 13 formula designs consisting of a combination of PVP K 30, ethyl cellulose and menthol. Each formula was tested for organoleptic, thickness, weight uniformity, moisture and folding resistance. Then the optimum formula was determined and analyzed using the simplex lattice design method. The combination of PVP K 30, ethyl cellulose and menthol with a simplex lattice design has an effect on the transdermal patch of diclofenac potassium which increases the consistency of the patch surface, reduces the thickness directly proportional to the weight of the patch and increases folding resistance. The proportion of PVP K 30, ethyl cellulose and menthol that can produce the optimum formula for diclofenac potassium transdermal patches with the simplex lattice design on the critical parameters of thickness, moisture, folding resistance and penetration tests, namely PVP K 30 of 14.87%, ethyl cellulose of 10.00% and 5.13% menthol.

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Section: Formulation Of Film Patch Diclofenac Potassiummentioning

confidence: 99%

Optimization of Diclofenac Potassium Transdermal Patch Formula Using a Combination of Polyvynil Pyrrolidone K 30, Ethyl Cellulose and Menthol With Simplex Lattice Design Method

Gunawan,

Supriyadi,

Kuncahyo

2024

JFSP

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“…Zero order kinetics is determined by the plotting the percentage of release versus time (h), first order kinetics by plotting the logarithmic value of release versus time (h) and the Higuchi order kinetics is determined by making a percentage release of drug versus the square root of time. [18] Stability Studies:-The stability studies of the formulated transdermal patches were studied on prepared film at different temperature and humidity 45-50°C (75%RH) over a period of 45 days. The patches were wrapped in aluminum foil and stored in desiccators for stability study.…”

Section: Evaluation Of Transdermal Patches:-mentioning

confidence: 99%

“Formulation and Evaluation of Transdermal Patches of Prednisolone”

Chirayu.¹,

T.S²,

Vijapure³

2019

JBPR

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The purpose of this research work was to develop and evaluate transdermal patch of Prednisolone, using Xanthan gum, Guar gum and Polyacrylamide in different ratios prepared by the Glass Substrate Technique. The physicochemical compatibility of the polymers and the drug was evaluated by FTIR. The results suggested that no physicochemical incompatibility between the polymer and the drug. Drug free films were formulated and evaluated characteristics like flexibility and smoothness. Further drug loaded films were formulated and evaluated for thickness, weight uniformity, drug content, folding endurance and drug release. The XRD analysis confirmed the amorphous dispersion of the drug in the formulation. SEM analysis showed surface morphology of prepared formulations. Drug diffusion through cellophane membrane was carried out using Franz diffusion cell by in-vitro study. The film prepared with formulation PDS 9 showed maximum diffusion release at the end of 24 hours. It is shown that drug release follows order and non Fikinian mechanism of release diffusion. The PDS 9 formulation was found to be stable with respect to drug content as well as physical changes at 40 ºC and 75 % RH. Keywords: Transdermal drug delivery, Prednisolone, Xanthan gum, Guar gum, Polyacrylamide.

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“…However, numerous reviews also discussed and described drug release kinetic models and mechanisms [3][4][5][6]. In this context, however, ketoprofen, an important non-steroidal anti-inflammatory chiral drug [7], known to have short half-life time, has been studied in different formulae and matrices for sustained release, controlled release, and dissolution enhancement [8][9][10][11][12][13][14][15][16][17][18], tablets [19][20][21], patches [22], fibers [23], and beads [24]. On the contrary, the release kinetics of ketoprofen enantiomers from chiral matrices was rarely studied [25].…”

Section: Introductionmentioning

confidence: 99%

In vitro kinetic release study of ketoprofen enantiomers from alginate metal complexes

Alkhayer

Khudr²,

Koudsi

2021

Futur J Pharm Sci

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Background To explore the release behavior of ketoprofen enantiomers from alginate-metal-complexes. Five mathematical models of drug release kinetics were investigated. Results Beads of alginate-metal complexes, loaded with racemic ketoprofen, were prepared by the ionotropic method. Divalent (Ca, Ba, Zn) and trivalent (Fe, Al) metals were used in the preparation of single-metal and mixed-metal alginate complexes. In vitro release experiments were carried out in an aqueous phosphate buffer medium at pH = 7.4. The concentrations of ketoprofen released enantiomers were determined using chiral HPLC technique. The obtained data were used to simulate the release kinetic of ketoprofen enantiomers using various mathematical models. The Korsmeyer-Peppas model was the best fit for Ca, Al, and Fe beads. Moreover, alginate-iron beads tend to release the drug faster than all other cases. In contrast, the drug release for alginate-barium complex was the slowest. The presence of barium in alginate mixed-metal complexes reduced ketoprofen release in the case of Fe and Zn, while it increased the release in the case of Al complex. Conclusion In all the studied cases, ketoprofen showed very slow release for both enantiomers over a period exceeded 5 h (10 days in some cases). The release rate modification is possible using different multivalent metals, and it is also feasible by using two different metals for congealing either consecutively or simultaneously.

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In vitro Permeation Study of Ketoprofen Patch with Combination of Ethylcellulose and Polyvynil Pyrrolidone as Matrix Polymers

Cited by 6 publications

References 14 publications

Optimization of Diclofenac Potassium Transdermal Patch Formula Using a Combination of Polyvynil Pyrrolidone K 30, Ethyl Cellulose and Menthol With Simplex Lattice Design Method

Optimization of Diclofenac Potassium Transdermal Patch Formula Using a Combination of Polyvynil Pyrrolidone K 30, Ethyl Cellulose and Menthol With Simplex Lattice Design Method

“Formulation and Evaluation of Transdermal Patches of Prednisolone”

In vitro kinetic release study of ketoprofen enantiomers from alginate metal complexes

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