Optimization of Diclofenac Potassium Transdermal Patch Formula Using a Combination of Polyvynil Pyrrolidone K 30, Ethyl Cellulose and Menthol With Simplex Lattice Design Method
Sahrul Gunawan,
Supriyadi Supriyadi,
Ilham Kuncahyo
Abstract:Diclofenac potassium is one of the NSAID drugs which can cause gastrointestinal irritation and damage to the small intestinal mucosa including erosion and ulceration. The purpose of this study was to determine the effect of the combination of PVP K 30, ethyl cellulose and menthol on organoleptic, thickness, weight uniformity, moisture and folding resistance of diclofenac potassium transdermal patch.This research is an experimental study that includes an experiment to optimize the formulation of a transdermal p… Show more
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