In vitro Evaluations of Biodegradable Polyacrylamide Grafted Moringa Bark Gum Graft Copolymer (MOG-g- PAAM) as Biomedical and Controlled Drug Delivery Device Synthesized by Microwave Accelerated free Radical Synthesis

Abstract

Aim:The present work is based on preparation of different grades of Moringa Bark Gum (MOG) with Acrylamide (AM) with varying amount of AM (monomer) and APS (redox initiator) using microwave accelerated free radical reaction. Objectives: In the current work, the Moringa bark gum grafted with acrylamide graft copolymer was tested for tissue engineered polymeric scaffold as well as controlled drug delivery system using metronidazole as a model drug. Methodology: The microwave radiation process was used along with redox initiator for the graft copolymerization process and the optimization of the grades was done using % grafting efficiency, intrinsic viscosity. Moreover, the optimized grade GF4 was analyzed with FTIR as well as NMR proving efficient grafting has resulted along with TGA, OCA and XRD. Results: The grade GF4 showed 95% drug release for 24 hours with only 1% hemolysis proving non-toxic and SEM images evidence its biodegradability thereby making the grade GF4 suitable for controlled release as well as tissue engineered scaffold. Conclusion: The results indicated that the optimized grade GF4 can be utilized as biodegradable polymer having applications in controlled delivery of drugs as well as scaffold for cell proliferation in wound healing and burn therapies.

Green nanofiber mat from HLM–PVA–Pectin (Hibiscus leaves mucilage–polyvinyl alcohol–pectin) polymeric blend using electrospinning technique as a novel material in wound-healing process

“…If degree of hemolysis is below the hemolysis index of 2%, a material is considered as non-hemolytic according to the American Society for Testing and Materials (ASTM). (Roy et al 2020 ) (Rai et al 2020 ) Therefore, the optimized sample CrNF(S7-CL) can be concluded as safe and can be explored in biomedical and tissue engineering (Table 5 ).…”

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“…The acrylamide and guar gum grafting was established by a sharp peak at 1670cm -1 which signified the carbonyl group of amide moiety of the grafted acrylamide chain and was not detected in guar gum spectrum. The -NH stretching of the graft polymeric network at 3186cm -1 was coincided with a broad peak lying between 3858cm -1 and 2940 cm -1 of hydroxyl group of guar gum (Rai et al, 2020).…”

Carboxymethylated Gums and Derivatization: Strategies and Significance in Drug Delivery and Tissue Engineering

“…Polysaccharides, which are requisite polymers found in plants, animals, fungi, and bacteria, are one of the leading trends in modern medicine [ 1 , 2 ]. Due to their nontoxicity, affordability, ease of availability, biosafety, biodegradability, and widespread regulatory approval, natural polysaccharides outperform synthetic ones in many ways [ 3 , 4 , 5 ]. Natural polysaccharides exhibit adequate biological properties but are less suitable as drug carriers than synthetic polymers, as their structure and property correlation revealed certain drawbacks.…”