In vitro evaluation of bacteriostatic activity of metal complexes of amodiaquine and primaquine

Gupta

Appl. Organometal. Chem.

et al. 1999

Boron chemistry has been intensively studied in the recent past. Although the study of the interactions between transition‐metal ions and the phenyl methylene ester derivatives of hydrazine carbodithioic acids has been carried out on a long period, particularly via the formation of adducts, their interaction of Main Group metal ions and the formation of their coordination complexes are subjects of current interest. We have synthesized and isolated a variety of complexes of phenyl dihydroxyborane with substituted dithiocarbazates. The benzene‐soluble, high‐molecular‐weight complexes have been characterized using a wide range of analytical and spectroscopic techniques. The pathogenicity of microbial infections associated with the complexes have been subjected to a variety of biointeraction studies and the results are discussed. Copyright © 1999 John Wiley & Sons, Ltd.

Section: Biocidal Screeningmentioning

confidence: 99%

Mononuclear boron(III) complexes of neo bidentate thioimines derived from hydrazinecarbodithioic acid

Gupta

Appl. Organometal. Chem.

et al. 1999

“…Due to greater lipoid solubility, the complexes facilitate their diffusion through the spore membrane to the site of action within spores, ultimately killing them by combining with -SH groups of certain cell enzymes. 25 The variation in the effectiveness of different biocidal agents against different organisms as suggested by Lawrence et a1. 26 depends on the impermeability of the cell.…”

Section: Mode Of Actionmentioning

confidence: 99%

Triorganosilicon(IV) complexes as biocides: Synthetic, spectroscopic and biological studies of N SH and N OH fluoroimines and their chelates

1995

Applied Organom Chemis

A facile synthesis and study of the stereochemistry and biochemical aspects of some triorganosilicon(IV) complexes derived from fluoroimines having N S and N O systems are reported. The fluoroimines were prepared by the condensation of 2‐fluorobenzaldehyde and 1‐(2‐fluorophenyl)ethanone with semicarbazide and thiosemicarbazide. These imines react with triorganosilicon(IV) chlorides to yield compounds having SiO/SiS and Si ← N bonds. The structures of the compounds have been elucidated by physicochemical and spectral (UV, IR, 1H NMR, 13C NMR and 9F NMR) studies which clearly point to a trigonal bipyramidal geometry around silicon(IV), as the active lone pair of nitrogen is also included in the coordination sphere. In the search for better fungicides and bactericides, studies were conducted to assess the growth‐inhibiting potential of the synthesized complexes against various pathogenic fungal and bacterial strains. These studies demonstrate that the concentrations reached levels which are sufficient to inhibit and kill the pathogens.

“…Due to greater lipoid solubility, the complexes facilitate their diffusion through membrane to the site of action and ultimately kill them by combining with (-SH) groups of cell enzymes. 30 The organoboron(II1) complexes are quite stable and are sparingly soluble in water. As regards the mechanism of biological activity, in general, it seems that compounds which are amides or esters tend to hydrolyse in the presence of water and form compounds which are either inert or have modified activity ~p e c t r a .~' Fungal and bacterial cells accumulate the water-soluble complex, which later dissociates to give the free central atom or its complex ion.…”

Section: Mode Of Actionmentioning

confidence: 99%

Stereochemical and biochemical aspects of organoboron(III) compounds of hydrazonecarboxamides and hydrazonecarbothioamides

1995

Applied Organom Chemis

Hydrazonecarboxamides and hydrazonecarbothioamides and their derivatives have important pharmacodynamic significance. In the search for better fungicides and bactericides, organoboron-(111) compounds derived from these ligands were screened for their antifungal and antibacterial activities. The heterocyclic aldimines were prepared by the condensation of (Zfuranyl)methanal, (Zthienyl)methanal, (2-pyridinyl)methanaI, (1H-indol-3-y1)methanal or 3-phenyl-2-propenal with hydrazinecarboxamide or hydrazinecarbothioamide. Unimolar and bimolar reactions between phenyldihydroxyborane and these ligands have produced PhB(OH)(NO), PhB(NO), , PhB(OH)(NS) and PhB(NS)* types of biologically active compounds. Structural assignment has been made through UV, IR and NMR ('H, "B and 13C) spectroscopy. TGA and XRD of a representative compound have also been carried out. The compounds were tested in vitro against a number of fungal and bacterial strains and were found to possess moderate to good toxicity.