In vitro Evaluation of Antioxidant and Antiproliferative Activities of Artemisia nilagirica Extracts

Gul, Mir Zahoor; Bhat, Mohd Yasin; Maurya, Radheshyam; Qureshi, Insaf Ahmed; Ghazi, Irfan Ahmad

doi:10.4172/pharmaceutical-sciences.1000303

Cited by 10 publications

(7 citation statements)

References 59 publications

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“…APA (Sox) seed extract possesses a significant antioxidant potential as indicated by DPPH free radical scavenging with an IC 50 value of 14.82 ± 0.85 µg/mL as compared to other extracts. Previously, reports have demonstrated that A. precatorius ethanol leaf extracts had antioxidant potential, with IC 50 values of 33.37 μg/mL, 60.67 ± 1.03 µg/mL and 266.13 ± 1.2 µg/mL 32 – 34 . The antioxidant capacity of A. precatorius seed oil has also been demonstrated, with an IC 50 value of 5.03 ± 0.24 mg/mL 35 .…”

Section: Discussionmentioning

confidence: 95%

“…It is influenced by a variety of factors and cannot be evaluated fully using a single approach. To account for the varied mechanisms of antioxidant action, different types of antioxidant capacity measurements should be performed 32 . Hence, we employed different in-vitro assays to get a broader perspective on the antioxidant potential of this plant.…”

Section: Discussionmentioning

confidence: 99%

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In-vitro antiproliferative efficacy of Abrus precatorius seed extracts on cervical carcinoma

Kaur

Sharma

Kumar³

et al. 2022

Sci Rep

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Abrus precatorius is a tropical medicinal plant with multiple medicinal benefits whose seeds have not yet been studied against cervical cancer. Herein, we have assessed the antioxidant and antiproliferative properties of seed extracts (ethyl acetate and 70% ethanol) prepared from Soxhlet and Maceration extraction methods against Hep2C and HeLa Cells. We observed that the APE (Sox) extract had a significantly higher total flavonoid content, APA (Mac) extract had a high total phenolic content, and APA (Sox) extract had a high total tannin content. Further, HPLC analysis of extracts revealed the presence of tannic acid and rutin. Moreover, APA (Sox) exhibited the highest free radical scavenging activity. APE (Mac) had the best antiproliferative activity against Hep2C cells, while APA (Sox) had the best antiproliferative activity against HeLa cells. In Hep2C cells, APE (Mac) extract revealed the highest SOD, catalase activity, GSH content, and the lowest MDA content, whereas APA (Mac) extract demonstrated the highest GST activity. In HeLa cells, APA (Sox) extract showed the highest SOD, GST activity, GSH content, and the least MDA content, whereas APA (Mac) extract showed the highest catalase activity. Lastly, docking results suggested maximum binding affinity of tannic acid with HER2 and GCR receptors. This study provides evidence that A. precatorius seed extracts possess promising bioactive compounds with probable anticancer and antioxidant properties against cervical cancer for restricting tumor growth.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

In-vitro antiproliferative efficacy of Abrus precatorius seed extracts on cervical carcinoma

Kaur

Sharma

Kumar³

et al. 2022

Sci Rep

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“…Toxicity of anticancer drugs such as doxorubicin is toxic to mouse peritoneal cells by production of Toll-Like Receptor 4 (TLR4) which also causes the cells to be sensitive to endotoxins which may cause the cells to die [ 53 ]. Studies have shown that the toxicological effect of phytochemicals is usually minimal to mouse macrophages [ 54 ]. Many phytochemicals such as saponins, lectins, starch, polypeptides, and lectins are not toxic to T and B cells [ 55 , 56 ].…”

Section: Resultsmentioning

confidence: 99%

The Effects of Combining Cancer Drugs with Compounds Isolated from Combretum zeyheri Sond. and Combretum platypetalum Welw. ex M.A. Lawson (Combretaceae) on the Viability of Jurkat T Cells and HL-60 Cells

Wende

Sithole

Fru

et al. 2021

BioMed Research International

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Combretum zeyheri and Combretum platypetalum have been shown to have anticancer, antibacterial, antituberculosis, and antifungal effects in both in vivo and in vitro studies. This study sought to evaluate the antiproliferative effects of compounds isolated from C. zeyheri and C. platypetalum on Jurkat T and HL-60 cancer cell lines in combination with doxorubicin and/or chlorambucil. At their GI50 concentrations, the isolated compounds were combined with the corresponding GI50 of chlorambucil and doxorubicin. The cytotoxic effects of the combined compounds were determined on BALB/c mouse peritoneal cells. All the 4 isolated compounds had significant cytotoxic effects on Jurkat T cells. Compounds CP 404 (1), CP 409 (2), CZ 453 (3), and CZ 455 (4) had GI50s on Jurkat T cells of 3.98, 19.33, 6.82, and 20.28 μg/ml, respectively. CP 404 (1), CP 409 (2), CZ 453 (3), and CZ 455 (4) showed GI50s of 14.18, 28.69, 29.87, and 16.46 μg/ml on HL-60 cancer cell lines, respectively. The most potent combination against Jurkat T cells was found to be CP 404 (1) and chlorambucil. This combination showed no cytotoxic effects when tested on BALB/c mouse peritoneal cells. It was concluded that the compounds extracted from C. zeyheri and C. platypetalum inhibit the growth of Jurkat T cells in vitro. The combination of the compounds with anticancer drugs enhanced their anticancer effects. The combination of CP 404 (1) and chlorambucil was found not to be toxic to normal mammalian cells. Therefore, CP 404 (1), 3-O-β-L-rrhamnopyranosyl-5,7,3 ′ 4 ′ ,5 ′ -pentahydroxyflavone, has the potential to be a source of lead compounds that can be developed for anticancer therapy. Further structure-activity relationship studies on this compound are warranted.

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“…include (monoterpenoids, sesquiterpenoids, α-thujone, β-thujone, germacrene D, 4-terpineol, β-caryophyllene, camphene, borneol, caryophyllene oxide, camphor, monoterpene hydrocarbon, sesquiterpene hydrocarbon, monoterpene alcohol, sesquiterpene oxide, and sesquiterpene alcohol), and phytochemicals (tannins, flavonoid, alkaloids, saponins, coumarins, and phenols [37][38][39]. The plant has pharmacological effects of anti-asthmatic, antiinflammatory, antimicrobial, antibacterial, and antioxidant [40][41][42][43]. Conventionally, the plant used in the treatment for epilepsy, diuretic, anti-inflammatory, and nervous disorders.…”

Section: Artemisia Nilagirica (Cb Clarke) Pampmentioning

confidence: 99%

A Literary Review Ofthe Contents of Thulasi Ennai (Pediatric Siddha Formulation) in the Management of Pediatric Bronchial Asthma

Sonitha

S²,

P³

et al. 2022

Asian J Pharm Clin Res

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Objectives: The purpose of this review article is focused on the photochemical constituents and therapeutic potential of Thulasi Ennai to combat pediatric bronchial asthma. Methods: The electronic databases such as Google Scholar, Medline/PubMed, Web of Science, Science Direct, Scopus and Directory of Open Access Journals (DOAJ), and reference lists have been looked to identify publications pertinent to the individual herbs of Thulasi Ennai. Results: The pharmacological effects of the herbs found in Thulasi Ennai possess anti-asthmatic, anti-inflammatory, antibacterial, antiviral, and other pharmacological effects relevant to the management of bronchial asthma. Conclusion: The present review concluded the safety of the Thulasi Ennai in preclinical studies. Further, clinical studies of Thulasi Ennai would need to be performed in humans to assess the efficacy of Thulasi Ennai.

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In vitro Evaluation of Antioxidant and Antiproliferative Activities of Artemisia nilagirica Extracts

Cited by 10 publications

References 59 publications

In-vitro antiproliferative efficacy of Abrus precatorius seed extracts on cervical carcinoma

In-vitro antiproliferative efficacy of Abrus precatorius seed extracts on cervical carcinoma

The Effects of Combining Cancer Drugs with Compounds Isolated from Combretum zeyheri Sond. and Combretum platypetalum Welw. ex M.A. Lawson (Combretaceae) on the Viability of Jurkat T Cells and HL-60 Cells

A Literary Review Ofthe Contents of Thulasi Ennai (Pediatric Siddha Formulation) in the Management of Pediatric Bronchial Asthma

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