Medicinal plants have been used in traditional medicines for their unmatched availability of bioactive compounds. Asthma is the most common chronic disease among children worldwide. It is ranked 16th among the leading causes of years lived with disability. Medicinal plants have placed a vital role in the siddha system of medicine over centuries to cure acute and chronic illness. The aim of the present study was to investigate toxicity analysis to evaluate safety of the siddha drug Thulasi Ennai in vivo in wistar albino rats. Thulasi Ennai is a polyherbal siddha formulation mentioned in the ancient siddha books and literature, indicated to cure childhood bronchial asthma. In this study, Thulasi Ennai administered orally at a single dose of 2000mg/kg body weight and monitored for 14 days. For subacute toxicity study, Thulasi Ennai was orally administered in different doses of 200,400mg/kg body weight, daily for 28 days. At the end of each study physical parameters, hematological, biochemical and histopathological analysis were evaluated. No animals in each group of acute or subacute toxicity study showed mortality or clinical signs of toxicity throughout the study. Hence, the results of the study indicate a safe toxicological profile of Thulasi Ennai.
In India, traditional medicine practices were followed for centuries. Tirunelveli district were located in south Tamil Nadu has very strong background on traditional practices particularly during postnatal care in which medicinal plants play a major role. The indigenous practices have herbal formulations, traditional dietary practices, external application that are exclusively used during postnatal care to strengthen mother health and spiritual aspects of wellbeing. The results obtained from the study manifested the use of medicinal plants in south Indian traditional medicine practice in postnatal care.
The Siddha system of medicine is one of the six recognized systems in the Indian system of medicine. The medicines comprise herbals, minerals, metals, and animal origins. Thurusu (Copper Sulphate) is a naturally occurring inorganic compound, but it can be prepared synthetically as per the procedures present in the Siddha literature as Vaippu muraigal. It is used in Siddha medicine as a single drug or in combination drugs after the detoxification process, which is termed as “Suthimurai” particularly incorporated for Schedule E drugs, which are listed in the Drugs and Cosmetics Act of 1940. Therapeutically, administered in the form of Parpam, Chenduram and externally applied to cure even chronic wounds. In this study, thurusu prepared as per Vaippu murai to assess the concentration of heavy metals present in the drug. The preparations are based upon the Siddha literature “Bogarsarakkuvaippu-800”. The heavy metals present in the Thurusu vaippu were analysed and the results showed the presence of heavy metals below the detection limit, but copper (350.125mg/l) and sulphur (471.204 mg/l) are present above the limit of the pharmacopoeial laboratory for Indian medicine (PLIM) guideline. Further processing of Suthimuraigal determines the concentration level of Thurusu vaippu for therapeutic purposes. Further research on Thurusu vaippu which paved the way to standardize the Thurusu vaippu muraigal.
Objectives: The purpose of this review article is focused on the photochemical constituents and therapeutic potential of Thulasi Ennai to combat pediatric bronchial asthma. Methods: The electronic databases such as Google Scholar, Medline/PubMed, Web of Science, Science Direct, Scopus and Directory of Open Access Journals (DOAJ), and reference lists have been looked to identify publications pertinent to the individual herbs of Thulasi Ennai. Results: The pharmacological effects of the herbs found in Thulasi Ennai possess anti-asthmatic, anti-inflammatory, antibacterial, antiviral, and other pharmacological effects relevant to the management of bronchial asthma. Conclusion: The present review concluded the safety of the Thulasi Ennai in preclinical studies. Further, clinical studies of Thulasi Ennai would need to be performed in humans to assess the efficacy of Thulasi Ennai.
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