In vitro biological standardization, formulation and evaluation of directly compressed polyherbal anthelmintic tablets

Maddi, Ramaiah; Chakravathi, Guntupalli; Yasaswini, Kanuri

doi:10.1016/j.phcgj.2013.04.004

Cited by 16 publications

(14 citation statements)

References 4 publications

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“…Naturally occurring herbs and herbal ingredients organized into certain formula have been shown to have potential interaction effects. These include mutual enhancement, mutual assistance, mutual restraint and even mutual antagonism (Ramaiah et al, 2013). Hence, in this study, the results showed an antagonism effect instead of synergistic effect since single formulation exhibited the highest for TPC, TFC and DPPH.…”

Section: Effect Of Single Binary and Ternary Polyherbal Formulation mentioning

confidence: 54%

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Development and evaluation of polyherbal formulation for memory enhancement: study on its antioxidant properties and synergistic effects

Abidin¹,

Kormin²,

Anuar³

2019

Food Res.

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Centella asiatica, Piper sarmentosum and Morinda citrifolia is well-known for their memory enhancement contribution from traditional practices as well as recent researches. However, all three herbs are utilized individually and never mixed together. The nutrient data on the synergistic effect on all three herbs remain scarce. The aims of this research project were to apply Simplex-centroid mixture design in describing the study for the effect of polyherbal formulation on antioxidants properties and its synergistic effects. Based on results obtained, there was a significant difference in antioxidant properties of the polyherbal formulation. The results show the polyherbal formulation 3 and 13 (M. citrifolia only) has the highest antioxidant capacity when being tested with total phenolic content (TPC) (210.10 and 209.12 µg GAE/mL respectively) and 2,2-diphenyl-1- picrylhydrazyl (DPPH) (42.94 and 37.77%) assays. Contradict to this result, the highest in total flavonoid content (TFC) and 2,2-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) for describing antioxidant properties are formulations 1 and 11 (C. asiatica only). The TPC for formulation 1 and 11 are 479.8 µg RE/mL and 470 µg RE/mL respectively while ABTS radical inhibition for formulation 1 and 11 are 64.53% and 60% respectively. For ferric reducing ability of plasma (FRAP) assay, formulation 7 (2.11 µg FSE/mL) is the highest which have 1:1:1 ratio of each herb. In addition, TPC, TFC, and DPPH assays showed high antioxidant activities when only single herbs were added into the formulation. Meanwhile, ABTS and FRAP are prone to binary polyherbal formulation. Hence, this study showed an antagonism effect instead of synergistic effect since single formulation exhibited the highest for TPC, TFC and DPPH. All tests gave the lowest antioxidant properties when the mix was ternary polyherbal formulation.

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Section: Effect Of Single Binary and Ternary Polyherbal Formulation mentioning

confidence: 54%

“…Meanwhile, ABTS and FRAP are prone to binary polyherbal formulation. It is reported that herbal combination often produces a promising effect in treatment of diseases over a single drug (Ramaiah et al, 2013).…”

Section: Surface Contours Plot and Triangular-dimensional Contours DImentioning

confidence: 99%

Development and evaluation of polyherbal formulation for memory enhancement: study on its antioxidant properties and synergistic effects

Abidin¹,

Kormin²,

Anuar³

2019

Food Res.

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“…In India, whereas most of the Ayurvedic PHFs are manufactured and exported, the regulation of Ayurvedic herbal preparation manufacturing is somewhat less stringent, despite the establishment of Drugs and Cosmetic Act to control the manufacture and quality control. According to the good clinical practices, toxicity studies and clinical trials on herbal formulations are not mandatory for application of patents and grant of manufacturing licenses to the Ayurvedic herbal formulation manufacturer 8,19 .…”

Section: Limitations Of Polyherbal Formulationmentioning

confidence: 99%

“…Naturally occurring herbs and herbal ingredients organized into certain formula have been shown to have potential interaction effects. These include mutual enhancement, mutual assistance, mutual restraint and mutual antagonism 8 . In the Ayurvedic system of medicine mainly polyherbal compounds are used for treatment of various infections.…”

Section: Introductionmentioning

confidence: 99%

Polyherbal Formulation Concept for Synergic Action: A Review

Karole

Shrivastava

Thomas

et al. 2019

J. Drug Delivery Ther.

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Formulations restrain 2 or more than 2 herbs are called polyherbal formulation. Drug formulation in Ayurveda is based on 2 principles: Use as a single drug and use of more than one drug. The last is known as polyherbal formulation. The idea of polyherbalism is peculiar to Ayurveda even though it is tricky to explain in term of modern parameters. The Ayurvedic literature Sarangdhar Samhita tinted the idea of polyherbalism to attain greater therapeutic efficacy. Polyherbal formulation has been used all around the earth due to its medicinal and therapeutic application. It has also recognized as polyherbal therapy or herb-herb combination. The active phytochemical constituents of individual plants are inadequate to attain the desirable therapeutic effects. When polyherbal and herbo-mineral formulations combining the multiple herbs in a meticulous ratio, it will give an enhanced therapeutic effect and decrease the toxicity. The active constituents used from individual plant are inadequate to provide attractive pharmacological action. There are evidences that crude plant extracts often have greater potency rather than isolated constituents. In traditional medicine whole plants or mixtures of plants are used rather than isolated compounds. Due to synergism, polyherbalism confers some benefits which are not accessible in single herbal formulations. Polyherbal formulations express high effectiveness in numerous diseases with safe high dose. Based on the nature of the interaction, there are 2 mechanisms on how synergism acts (i.e., pharmacodynamics and pharmacokinetic). In words of pharmacokinetic synergism, the capacity of herb to ease the absorption, distribution, metabolism and elimination of the other herbs is focused. Pharmacodynamics synergism on the other hand, studies the synergistic effect when active constituents with similar therapeutic activity are targeted by diverse mechanism of action. The present review encompasses all the significant features of polyherbal formulation. Keywords: Polyherbal formulation, Ayurveda, Active constituents, Pharmacodynamics, pharmacokinetic

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“…These include mutual enhancement, mutual assistance, mutual restraint and mutual antagonism. 10 In the Ayurvedic system of medicine mainly polyherbal compounds are used for treatment of various infections. Bharangyadi polyherbal is a mixture of Clerodendrum serratum, Hedychium spicatum and Inula racemosa.…”

Section: Herb-herb Combinationsmentioning

confidence: 99%

An Update Review on Polyherbal Formulation: A Global Perspective

Aslam¹,

Ahmad²,

Mamat³

et al. 2016

SRP

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Polyherbal formulation has been used all around the world due to its medicinal and therapeutic application. It has also known as polyherbal therapy or herb-herb combination. This article enlists some commercial and noncommercial polyherbal formulation all around the world. The authors have focused last six years of Publications on Polyherbal formulation in different countries and found that India have topped among the number of publications on polyherbal formulation followed by Nigeria, South Korea, Pakistan and Bangladesh. List of other countries also mentioned on scientific contribution of polyherbal therapy. The authors have mentioned list of publications on polyherbal formulation in the treatment of different diseases are based on pharmacological activity in the year 2015 and found that most polyherbal formulation found in the treatment of diabetes followed by an antioxidant, Hepatoprotective, Anti-inflammatory and anxiety disorder.

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In vitro biological standardization, formulation and evaluation of directly compressed polyherbal anthelmintic tablets

Cited by 16 publications

References 4 publications

Development and evaluation of polyherbal formulation for memory enhancement: study on its antioxidant properties and synergistic effects

Development and evaluation of polyherbal formulation for memory enhancement: study on its antioxidant properties and synergistic effects

Polyherbal Formulation Concept for Synergic Action: A Review

An Update Review on Polyherbal Formulation: A Global Perspective

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