In vitro antiplasmodial activity of Brazilian Cerrado plants used as traditional remedies

Mesquita, Mariana Laundry de; Grellier, Philippe; Mambu, Lengo; Paula, José Elías de; Espindola, Laïla Salmen

doi:10.1016/j.jep.2006.09.015

Cited by 92 publications

(74 citation statements)

References 45 publications

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“…Besides this antitumor potentiality, different parts of the plant also exhibit activity against Leishmania donovani promastigotes (Mesquita et al 2005), Trypanosoma cruzi amastigotes (Espíndola et al 2004, Mesquita et al 2005, Plasmodium falciparum strains resistant to chloroquine (Mesquita et al 2007) and Aedes aegypti larvae (Rodrigues et al 2006). Leaf methanolic extract shows anti-hyperlipidemic properties, decreasing serum triglycerides and lipases (Schoenfelder et al 2008) and the water extract displays neuromodulatory effects on central nervous system by the interference on enzymatic action of the purinergic and cholinergic systems since it inhibits Na + -/K + /ATPase and 5 -nucleotidase activities (Silva et al 2006).…”

Section: Antitumor Activitymentioning

confidence: 99%

Folk uses and pharmacological properties of Casearia sylvestris: a medicinal review

Ferreira

Costa-Lotufo

Moraes

et al. 2011

An. Acad. Bras. Ciênc.

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Folk uses and scientific investigations have highlighted the importance of Casearia sylvestris extracts and their relevant bioactive potential. The aim of this work was to review the pharmacological properties of C. sylvestris, emphasizing its anti-ulcer, anti-inflammatory, anti-ophidian and antitumor potentialities. Ethanolic extracts and essential oil of their leaves have antiulcerogenic activity and reduce gastric volume without altering the stomach pH, which corroborates their consumption on gastrointestinal disorders. Leaf water extracts show phospholipase A 2 inhibitory activity that prevents damage effects on the muscular tissue after toxin inoculation. This antiphospholipasic action is probably related to the use as an anti-inflammatory, proposing a pharmacological blockage similar to that obtained with non-steroidal anti-inflammatory drugs on arachidonic acid and cyclooxygenase pathways. Bioguided-assay fractionations lead to the identification of secondary metabolites, especially the clerodane diterpenes casearins (A-X) and casearvestrins (A-C), compounds with a remarkable cytotoxic and antitumor action. Therefore, the C. sylvestris shrub holds a known worldwide pharmacological arsenal by its extensive folk utilization, exciting searches for new molecules and a better comprehension about biological properties.

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Section: Antitumor Activitymentioning

confidence: 99%

Folk uses and pharmacological properties of Casearia sylvestris: a medicinal review

Ferreira

Costa-Lotufo

Moraes

et al. 2011

An. Acad. Bras. Ciênc.

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“…Aspidosperma subincanum também foi indicada para problemas associados ao aparelho digestivo (Monteles & Pinheiro, 2007), e para o tratamento tanto do diabetes e da hipercolesterolemia (Tresvenzol et al, 1997 vitro em Plasmodium falciparum (Mesquita et al, 2007). A quina-do-cerrado (Strychnos pseudoquina St.…”

Section: Em Nossa Senhora Do Livramento-mtunclassified

Levantamento etnobotânico de plantas utilizadas como anti-hiperlipidêmicas e anorexígenas pela população de Nova Xavantina-MT, Brasil

Silva¹,

Melo²,

Ribeiro³

et al. 2010

Rev. bras. farmacogn.

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RESUMO:O presente trabalho verificou a utilização de plantas medicinais encontradas no Cerrado mato-grossense para o tratamento de hiperlipidemias e obesidade. Entrevistas com 180 pessoas acima de 50 anos foram realizadas em Nova Xavantina-MT. O questionário abordou nome popular, parte utilizada, forma de preparo e uso das espécies citadas, além de informações gerais sobre o uso de plantas. -Hil.). A folha foi a parte mais utilizada (46%) e o preparo das plantas ocorre principalmente por meio de infusão citado por 36,5% dos entrevistados. Apesar do uso popular destas plantas no combate as hiperlipidemias e obesidade, há necessidade de estudos fitoquímicos e farmacológicos que comprovem estas atividades, com vistas ao desenvolvimento de um fitoterápico.Unitermos: Levantamento etnobotânico, Nova Xavantina, plantas medicinais, anti-hiperlipidêmicas, anorexígenas, Cerrado.ABSTRACT: "Ethnobotanical survey of plants used as anti-hyperlipidemic and anorexigenic by the population of Nova Xavantina-MT, Brazil". This study checked the use of medicinal plants found in the Cerrado mato-grossense for the treatment of hyperlipidemia and obesity. Interviews with 180 people over 50 years were held in Nova Xavantina-MT. The questionnaire addressed popular name, part used, type of preparation and use of the species mentioned, beyond general information about the use of plants. The ten plants most cited were collected, identified and studied through a literature review. Most respondents (95.6%) said using medicinal plants regularly, while 71.5% of them inherited the knowledge of plants of parents and grandparents and 94.20% reported the use to advise youngsters. Furthermore, 93.6% attested that the plants are more effective than the drugs from pharmacy and 57% considered the strong effect of the same, i.e., they always solved health problems. Regarding adverse effects, 95.9% said they have never felt them after the use of plants. Of the respondents, 56.7% knew or had used medicinal plants in the treatment of hyperlipidemias and obesity, being cited 54 medicinal species belonging to 53 different genera and 38 families, with emphasis on Fabaceae (13%

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“…The infusion of leaves and powdered seeds is used to combat diarrhea and induce menstruation (Almeida et al, 1994;Silva et al, 1994). In Brazil, A. coriacea, "marolo", is popular used against chronic diarrhea (Rodrigues and Carvalho, 2001), antimalarial (Mesquita et al, 2007), anti-helmintic Sant'Ana, 2000, 2001), and leishmaniasis (Akendengue et al, 1999). The leaves of the A. sylvatica, "araticum da mata", are used to treat malaria or as a febrifuge (Balbach, 1986).…”

Section: Introductionmentioning

confidence: 99%

Contents of constituents and antioxidant activity of seed and pulp extracts of Annona coriacea and Annona sylvatica

et al. 2015

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The antioxidant potential of fruit pulp and seeds of extracts of the Annona coriacea, and A. sylvatica (Annonaceae) were investigated, as well contents total phenolics, flavonoids, condensed tannins and ascorbic acid. Was used to determine the antioxidant activity the 1,1-diphenyl-1-picrylhydrazyl free radical (DPPH), β-carotene bleaching and ABTS radical cation method. The total phenol, total flavonoid, condensed tannin, and ascorbic acid contents were measured spectrophotometrically. In this study, the pulp and seeds of the fruits were extracted using methanol/water (8:2) for maceration. The seed extracts of A. coriacea demonstrated a moderate antioxidant effect with free radical scavenging activity of 31.53%, by the DPPH test, 51.59% by the β-carotene bleaching test and 159.50 µM trolx/g of extract in the ABTS assay. We found that the hydromethanolic seed extract of A. coriacea had high total phenol (147.08 ± 4.20 mg of GAE/g of extract) and flavonoid (131.18 ± 2.31 mg of QE/g of extract) content. This indicated that the antioxidant activity of the extracts was related to the contents of these constituents.Keywords: Annona, antioxidant activity, phytochemistry. Conteúdo

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In vitro antiplasmodial activity of Brazilian Cerrado plants used as traditional remedies

Cited by 92 publications

References 45 publications

Folk uses and pharmacological properties of Casearia sylvestris: a medicinal review

Folk uses and pharmacological properties of Casearia sylvestris: a medicinal review

Levantamento etnobotânico de plantas utilizadas como anti-hiperlipidêmicas e anorexígenas pela população de Nova Xavantina-MT, Brasil

Contents of constituents and antioxidant activity of seed and pulp extracts of Annona coriacea and Annona sylvatica

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