In vitro activity of taurolidine gel on bacteria associated with periodontitis

Abstract

Taurolidine gels may represent a potential alternative for adjunctive topical antimicrobial treatment in periodontitis and infectious peri-implant diseases.

Activity of taurolidine gels on ex vivo periodontal biofilm

“…Comparing TAU 3% with TAU 1% a clear concentration dependent activity was visible on total bacterial counts (cfu) as well as on selected species (P. gingivalis and T. denticola after 60 min) in biofilm. This is in agreement with findings from previous studies using a 12-species biofilm, where higher concentrations of taurolidine solutions [24] and taurolidine gels [25] were more bactericidal than lower ones. However, in the present study, there was no difference between the two taurolidine gels regarding biofilm quantity and metabolic activity.…”

“…However, a killing activity of an antimicrobial is generally defined as a reduction by at least 3 log10 over a defined time, here only 0.87 log10 were reached. In our previously performed study using a defined 12-species biofilm, the same antimicrobial (TAU 3%) reached 3.63 log10, [25]. There 3% taurolidine has been in contact with the biofilm for 60 min before diluting to 0.3%, in the present study dilution was already after 10 min to 0.3%.…”

“…An activity of the vehicle used in taurolidine gels on biofilm metabolic activity and biofilm quantity cannot be ruled out. In our previous study [25] no influence of the vehicle on bacterial counts was seen.…”

“…In earlier studies, the MICs of taurolidine against oral species were determined as all below 5% of the normally used concentration of that substance with the exception of Candida albicans [23]. Moreover, previous data from a series of studies performed in our laboratory have shown that taurolidine solutions and taurolidine gels inhibited clearly the formation of defined biofilms containing laboratory strains [24,25].…”

Sustained‐release delivery of antimicrobial drugs for the treatment of periodontal diseases: Fantasy or already reality?

“…A different antimicrobial agent was tested in a gel intrapocket delivery system . The authors used taurolidine, which is an antimicrobial that is mostly used to prevent catheter‐associated urinary tract infections.…”