In situ extractive fermentation for the production of hexanoic acid from galactitol by Clostridium sp. BS-1

Jeon, Byoung Seung; Moon, Chuloo; Kim, Byung Chun; Kim, Hyunook; Um, Youngsoon; Sang, Byoung In

doi:10.1016/j.enzmictec.2013.02.008

Cited by 84 publications

(54 citation statements)

References 32 publications

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“…This behavior is reflected in carboxylic acids productivities where~3-fold higher values were obtained in the pertractive system (0.26 g/L/h) compared to batch extractive (0.09 g/L/h). The pertractive productivity value in this work is the highest reported for the simultaneous production of VFAs using a mono-culture organism from sugars, greater than those obtained from sucrose 0.23 g/L/h [20] and glucose 0.13 g/L/h [21] considering both BA and HA or from acetate and ethanol 0.18 g/L/h [13] and galactitol 0.08 g/L/h [14] for exclusive HA production.…”

Section: Discussionmentioning

confidence: 71%

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Mixed Carboxylic Acid Production by Megasphaera elsdenii from Glucose and Lignocellulosic Hydrolysate

et al. 2017

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Volatile fatty acids (VFAs) can be readily produced from many anaerobic microbes and subsequently utilized as precursors to renewable biofuels and biochemicals. Megasphaera elsdenii represents a promising host for production of VFAs, butyric acid (BA) and hexanoic acid (HA). However, due to the toxicity of these acids, product removal via an extractive fermentation system is required to achieve high titers and productivities. Here, we examine multiple aspects of extractive separations to produce BA and HA from glucose and lignocellulosic hydrolysate with M. elsdenii. A mixture of oleyl alcohol and 10% (v/v) trioctylamine was selected as an extraction solvent due to its insignificant inhibitory effect on the bacteria. Batch extractive fermentations were conducted in the pH range of 5.0 to 6.5 to select the best cell growth rate and extraction efficiency combination. Subsequently, fed-batch pertractive fermentations were run over 230 h, demonstrating high BA and HA concentrations in the extracted fraction (57.2 g/L from~190 g/L glucose) and productivity (0.26 g/L/h). To our knowledge, these are the highest combined acid titers and productivity values reported for M. elsdenii and bacterial mono-cultures from sugars. Lastly, the production of BA and HA (up to 17 g/L) from lignocellulosic sugars was demonstrated.

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Section: Discussionmentioning

confidence: 71%

“…However, as the authors state, Clostridium sp. BS-1 displays poor glucose utilization, which would need to be improved if lignocellulosic sugars are to be used [14].…”

Section: Discussionmentioning

confidence: 99%

Mixed Carboxylic Acid Production by Megasphaera elsdenii from Glucose and Lignocellulosic Hydrolysate

et al. 2017

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“…The goal of this study is to develop a heterogeneous catalyst for the efficient production of the higher-energy-density C11 ketone from biologically produced hexanoic acid [18,19]. Attempts were made to avoid the possible leaching of base catalysts, and a stable amphoteric catalyst was developed for a feasible continuous flow reaction under an acid-rich environment.…”

Section: Introductionmentioning

confidence: 99%

“…In addition to the thermolysis and the anaerobic fermentation, biological processes which can be used to prepare carboxylic acids with higher carbon numbers, including butyric acid [16,17] and hexanoic acid [18,19], have been studied in the hope of preparing alternative fuels which blend better with gasoline and diesel. Although these carboxylic acids and their corresponding alcohols are promising as high-energy-density fuels, fuels with higher carbon numbers and with lower oxygen-to-carbon ratios can be better blended with gasoline and diesel, and the production of fuels with higher carbon numbers via a completely biological process have been developed [20].…”

Section: Introductionmentioning

confidence: 99%

Ketonization of hexanoic acid to diesel-blendable 6-undecanone on the stable zirconia aerogel catalyst

Lee

Choi

Suh

et al. 2015

Applied Catalysis A: General

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“…Caproic acid biosynthesis, by chain elongation of ethanol or acetic acid, is gaining interest since it can be separated with less energy input than ethanol and/or acetic acid (Vasudevan et al 2014). In-situ extraction of caproic acid have been reported from fermentation broth by waterimmiscible organic solvents (Choi et al 2013;Jeon et al 2013).…”

Section: Technological Importance Of Dark Fermentation Productsmentioning

confidence: 99%

Dark fermentation biorefinery in the present and future (bio)chemical industry

Bastidas‐Oyanedel

Bonk

Thomsen

et al. 2015

Rev Environ Sci Biotechnol

129

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Dark fermentation, also known as acidogenesis, involves the transformation of a wide range of organic substrates into a mixture of products, e.g. acetic acid, butyric acid and hydrogen. This bioprocess occurs in the absence of oxygen and light. The ability to synthesize hydrogen, by dark fermentation, has raised its scientific attention. Hydrogen is a nonpolluting energy carrier molecule. However, for energy generation, there is a variety of other sustainable alternatives to hydrogen energy, e.g. solar, wind, tide, hydroelectric, biomass incineration, or nuclear fission. Nevertheless, dark fermentation appears as an important sustainable process in another area: the synthesis of valuable chemicals, i.e. an alternative to petrochemical refinery. Currently, acetic acid, butyric acid and hydrogen are mostly produced by petrochemical reforming, and they serve as precursors of ubiquitous petrochemical derived products. Hence, the future of dark fermentation relies as a core bioprocess in the biorefinery concept. The present article aims to present and discuss the current and future status of dark fermentation in the biorefinery concept. The first half of the article presents the metabolic pathways, product yields and its technological importance, microorganisms responsible for mixed dark fermentation, and operational parameters, e.g. substrates, pH, temperature and head-space composition, which affect dark fermentation. The minimal selling price of dark fermentation products is also presented in this section. The second half discusses the perspectives and future of dark fermentation as a core bioprocess. The relationship of dark fermentation with other (bio)processes, e.g. liquid fuels and fine chemicals, algae cultivation, biomethane-biohythane-biosyngas production, and syngas fermentation, is then explored.

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In situ extractive fermentation for the production of hexanoic acid from galactitol by Clostridium sp. BS-1

Cited by 84 publications

References 32 publications

Mixed Carboxylic Acid Production by Megasphaera elsdenii from Glucose and Lignocellulosic Hydrolysate

Mixed Carboxylic Acid Production by Megasphaera elsdenii from Glucose and Lignocellulosic Hydrolysate

Ketonization of hexanoic acid to diesel-blendable 6-undecanone on the stable zirconia aerogel catalyst

Dark fermentation biorefinery in the present and future (bio)chemical industry

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