In ovo administration of recombinant human insulin-like growth factor-I alters postnatal growth and development of the broiler chicken

Kocamiş, Hakan; Kirkpatrick-Keller, D C; Klandorf, H.; Killefer, J.

doi:10.1093/ps/77.12.1913

Cited by 42 publications

(35 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Direct manipulations include the in-ovo injection of growth hormones or factors (e.g. insulinlike growth factor), amino acids, carbohydrates or neuromuscular active drugs into the embryos or its embryonic membranes (Kocamis et al, 1998;Heywood et al, 2005;Uni et al, 2005;McEntee et al, 2006;Pitsillides, 2006).…”

Section: Introductionmentioning

confidence: 99%

Increasing the incubation temperature between embryonic day 7 and 10 has no influence on the growth and slaughter characteristics as well as meat quality of broilers

Werner

Wecke

Liebert

et al. 2010

Animal

View full text Add to dashboard Cite

Avian embryogenesis can be manipulated by alteration of the temperature during incubation of the brooding egg. Investigations in turkeys showed that a higher temperature during early embryogenesis positively affects the myogenesis accompanied with a higher muscle fibre number (MFN). The aim of this study was to transfer this result to broiler and to investigate if an alteration of the temperature also affects the meat quality after slaughter of the birds. Therefore brooding eggs of the Cobb 500 broiler genetic were either incubated at 37.5°C during the whole incubation period (at normal temperature (NT)), or at 38.5°C during embryonic day (ED) 7 to 10 (at high temperature (HT)). After hatch the chicks were sexed and reared up to an age of 36 days in an experimental stable. Growth and feed conversion properties were determined during this period. After slaughter different meat quality characteristics as well as the muscle microstructure were analysed. The hatch rate and chick weight did not differ between the broiler of the NT and HT group. After 36 days the final body weights and the cumulative feed conversion rates were not different in the NT and HT groups. No differing results were obtained with regard to the slaughter, breast and leg weights of the NT and HT animals. Considering the gender of the animals no differences in the slaughter characteristics could be determined although the carcass and breast weights of the HT cocks were tendentially higher. The muscle fibre areas and MFNs in the breast muscles of the NT and HT cocks did not differ significantly and were in the range of the HT hens. Only the NT hens had significantly larger muscle fibres and less MFN than the other animals. With regard to the meat quality characteristics no clear differences of the pH, electrical conductivity (EC) and colour (L*a*b*) values were found. The L*a*b* values in the investigated breast muscles of all broilers usually increased during ageing. The increase of the incubation temperature had no impact on the hatch, growth, slaughter and meat quality characteristics of the broiler except for the tendentially higher carcass and breast weights of the HT cocks. However, the decrease of the fibre areas in the HT hens is an interesting effect of using a higher incubation temperature, which needs to be considered when implicating further investigations.

show abstract

Section: Introductionmentioning

confidence: 99%

Increasing the incubation temperature between embryonic day 7 and 10 has no influence on the growth and slaughter characteristics as well as meat quality of broilers

Werner

Wecke

Liebert

et al. 2010

Animal

View full text Add to dashboard Cite

show abstract

“…Overexpression ex-periments in chick embryos have shown that IGF-1 expands the undifferentiated myoblast population, resulting in an increase in muscle fiber number through the process of proliferation (Mitchell et al, 2002). Additionally, in ovo administration of IGF-1 has been shown to promote postnatal muscle growth (Kocamis et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Neuromuscular stimulation causes muscle phenotype‐dependent changes in the expression of the IGFs and their binding proteins in developing slow and fast muscle of chick embryos

McEntee

Simbi

Bayol

et al. 2006

Developmental Dynamics

View full text Add to dashboard Cite

Insulin-like growth factor (IGF) -1 and -2 and binding protein (IGFBP-2, -4, and -5) expression can be affected by several environmental factors, but the impact of movement on the IGF axis during late embryogenesis has yet to be fully characterized. Movement was promoted in chick embryos during midembryogenesis using 4-aminopyridine (4-AP). The results indicate an increase in IGF-1 (P < 0.01) and a decrease in IGFBP-2 (P < 0.05) mRNA expression in slow muscle of the stimulated group compared with the control group. In fast muscle, there was a decrease in IGF-2 (P < 0.01) on embryonic day (ED) 16 and an increase in IGFBP-2 (P < 0.01) and IGFBP-4 (P < 0.05) and in IGFBP-5 (P < 0.05) expression on ED18 in the stimulated group compared with the control group. These results indicate that neuromuscular stimulation with 4-AP influences IGF axis gene expression in a muscle fiber type-dependent manner. Consequences of the changes in the IGF system for each muscle are discussed.

show abstract

“…IGF-1, once bound to the IGF receptor-1, stimulates muscle cell proliferation and differentiation in the chicken (Duclos et al 1991). In ovo administration of recombinant human IGF-1 increased growth, feed efficiency and tissue development in posthatch broilers (Kocamis et al 1998). Tomas et al (1998) reported that the exogenous administration of IGF-1 significantly increased growth rate, nitrogen balance and food utilisation efficiency by around 10-15%, while carcass fat was consistently reduced.…”

mentioning

confidence: 99%

Effects of the plant extract YGF251 on growth performance, meat quality, relative organ weight, nutrient digestibility and blood profiles in broiler chickens: possible role of insulin-like growth factor 1

Begum¹,

Hossain²,

Kim³

2014

Vet. Med. - Czech

View full text Add to dashboard Cite

This study was aimed at evaluating the effects of different concentrations of the dietary plant extract supplement YGF251 (young growth factor) on growth performance, blood profiles, relative organ weight, nutrient digestibility and meat quality in broiler chickens. A total of 640 one-day-old male Arbor Acres broiler chickens with an average initial body weight of 40.25 ± 0.5 g were randomly allotted to one of four treatments lasting four weeks with 10 replicates per treatment and 16 chicks per replicate pen. Dietary treatments consisted of: CON (basal diet); YGF0.05 (CON + 0.05% YGF251); YGF0.1 (CON + 0.10% YGF251); YGF0.15 (CON + 0.15% YGF251). There were no statistical differences in body weight (BW), feed intake (FI) and feed conversion rate (FCR) throughout the whole experiment. However, broiler chickens fed with YGF0.1 diets had greater body weight gains (BWG) than chickens fed CON diets during eight to 28 days and zero to 28 days although the means of pH value, breast meat colour, WHC, drip loss, the relative organ weights of liver, spleen, bursa of Fabricius and breast muscle were not affected by any dietary supplementation (P > 0.05). The relative weight of abdominal fat in the CON treatment group was significantly higher than the YGF0.05 and YGF0.1 treatments, although relative gizzard weight was lower with CON treatment compared to YGF0.1 treatment (P < 0.05). Femur length and weight were significantly higher in the YGF251-supplemented chicks than in chicks fed the control diet (P < 0.05). Broiler chickens fed the YGF0.1 diet had significantly higher blood IgG counts compared to chicks fed the CON and YGF0.05 diets (P < 0.05). Moreover, YGF251-supplemented chicks exhibited increased IGF-I concentrations compared to the CON to YGF0.1 treatment (P < 0.05). The results of this study indicate that supplementation with 0.1% YGF251 can increase body weight, IgG and energy digestibility and reduce relative abdominal fat and gizzard weight in broiler chickens, while at all concentrations tested YGF251-supplemented chicks showed higher results for femur length and weight and serum IGF-I concentrations compared to the control treatment in broiler chickens. Keywords: broiler chickens; blood profile; growth performance; meat quality; plant extract List of abbreviations BW = body weight, BWG = body weight gain, FCR = feed conversion rate, FI = feed intake, YGF251 = young growth factor

show abstract

In ovo administration of recombinant human insulin-like growth factor-I alters postnatal growth and development of the broiler chicken

Cited by 42 publications

References 22 publications

Increasing the incubation temperature between embryonic day 7 and 10 has no influence on the growth and slaughter characteristics as well as meat quality of broilers

Increasing the incubation temperature between embryonic day 7 and 10 has no influence on the growth and slaughter characteristics as well as meat quality of broilers

Neuromuscular stimulation causes muscle phenotype‐dependent changes in the expression of the IGFs and their binding proteins in developing slow and fast muscle of chick embryos

Effects of the plant extract YGF251 on growth performance, meat quality, relative organ weight, nutrient digestibility and blood profiles in broiler chickens: possible role of insulin-like growth factor 1

Contact Info

Product

Resources

About