Improvement of platelet aggregation and rapid induction of hemostasis in chitosan dressing using silver nanoparticles

Mussel‐ and Barnacle Cement Proteins‐Inspired Dual‐Bionic Bioadhesive with Repeatable Wet‐Tissue Adhesion, Multimodal Self‐Healing, and Antibacterial Capability for Nonpressing Hemostasis and Promoted Wound Healing

“…Such enhanced blood clotting ability of the C‐CTS/SA‐Ag‐based hydrogels was primarily benefited from capture function of the introduced ionic crosslinking network as well as platelet activation effect of the Ag NPs. [ 14 ] The results from Figure 4A proved that blood in the control group did not spontaneously form coagulation and still remained as free‐flowing liquid; while as the blood was in full contact with the hydrogel for 120 s, the liquid blood was transformed into a clotted blood and held its weight upon tube inversion. Noticeably, amount of the hydrogel used in the experiment was one‐half of the blood, which was not able to bear the blood weight and would flow downward as the centrifuge tube was inverted, unless the thrombus was formed.…”

“…[ 50 ] Consequently, it is essential to evaluate antibacterial capability of the developed hydrogels in vitro against two bacterial isolates of Staphylococcus aureus ( S. aureus , Gram‐positive bacteria) and Escherichia coli ( E. coli , Gram‐negative bacteria). [ 14 ] As shown in Figure A,F, upon contacting with the bacteria for 24 h, the C‐CTS hydrogel exhibited slightly lower killing rates for both E. coli (92.90% ± 1.71%) and S. aureus (90.95% ± 1.87%) compared with those in the C‐CTS/SA‐Ag hydrogel (96.33% ± 1.25%, 92.25% ± 1.57%) and C‐CTS/SA‐Ag/dECM hydrogel (96.99% ± 0.25%, 92.90% ± 0.90%) groups. There were no statistically significant differences among these sample groups, so it was difficult to distinguish whether C‐CHI or Ag NPs dominated the antibacterial effect.…”

“…Furthermore, Ag NPs have been reported to accelerate production of thrombin by activating platelets and increasing exposure to phosphatidylserine. [ 14 ] As shown in Figure 1B, amounts of hydrogen bonding, cation–π, and electrostatic interactions among abundant catechol groups of TA, amino groups of C‐CHI or/and SF, and carboxyl groups of SA‐Ag existed in the C‐CTS/SA‐Ag/dECM composite hydrogel, which endowed the hydrogel with long‐term (30 d) and repeatable (15 times) robust adhesiveness against both dry and wet surfaces. Additionally, electron transfer between Ag NPs and TA, dynamic redox balance of phenol‐quinone, as well as TA‐triggered β‐conformational transition of SF further enhanced intrinsic toughness and underwater adhesion performance.…”

Green synthesized AgNPs from Periploca hydaspidis Falc. and its biological activities

“…The mechanism involved may be the higher surface area of nanoparticles coming in contact with blood and forming particle aggregation on the bleeding surface, hence resulting in coagulation and inhibition of bleeding (Luo et al, 2016). These PHAgNPs can act as efficient hemostatic agents with enough bio‐compatibilty for its use in controlling hemorrhage and in promoting wound‐healing after hemostasis surgery (Lan et al, 2020). Altogether, our results strengthen the findings of Nie et al, 2018, who reported the synthesized AgNPs incorporated with mesoporous silica granules as good compatibility agents with great hemostatic potential and sustained antibacterial activity particularly against MRSA strain, which further suggest them to serve for future therapeutic translation.…”

Bioactive and superabsorbent cellulosic dressing grafted alginate and Carthamus tinctorius polysaccharide extract for the treatment of chronic wounds

“…to which silver has been added in various physicochemical forms, theoretically for antibacterial purposes. 17,18 Furthermore, a new generation of efficient dressings based on hyaluronic acid has been established. They contain hyaluronic acid (a natural constituent of the dermis) at varying concentrations.…”