Mussel‐ and Barnacle Cement Proteins‐Inspired Dual‐Bionic Bioadhesive with Repeatable Wet‐Tissue Adhesion, Multimodal Self‐Healing, and Antibacterial Capability for Nonpressing Hemostasis and Promoted Wound Healing

Abstract

Massive bleeding and wound infection are the major problems often observed during severe trauma, and achieving rapid hemostasis in cases of high‐dose bleeding in arteries and viscera remains an acute clinical demand. Herein, a mussel‐ and barnacle cement proteins‐inspired dual‐bionic hydrogel is first proposed. Benefiting from abundant phenolic hydroxyl groups, a tough dissipative matrix, removal of interfacial water, as well as dynamic redox balance of phenol‐quinone, the multinetwork hydrogel achieves repeatable robust wet‐tissue adhesiveness (151.40 ± 1.50 kPa), a fast multimodal self‐healing ability, and excellent antibacterial property against both Gram‐positive/negative bacteria. For rabbit/pig models of cardiac penetration holes and femoral artery injuries, the dual‐bionic bioadhesive shows better hemostatic efficiency than commercial gauze due to the synergistic effect of strong wound sealing capability, excellent red blood cell capturing property, and activation of hemostatic barrier membrane. More interestingly, the hydrogel combined with commercial hemostatic sponge presents accelerated wound healing as well as great potential for treating deep‐wound hemorrhage in a battlefield environment. Overall, owing to these unique advantages, the novel tissue‐adhesive hemostat opens up a new avenue to rapid sealing hemostasis and wound healing applications.

Biomimetic Natural Biopolymer‐Based Wet‐Tissue Adhesive for Tough Adhesion, Seamless Sealed, Emergency/Nonpressing Hemostasis, and Promoted Wound Healing

“…[ 16 ] In terms of potential use as a hemostatic sealant, the hydrophilic surfaces of hydrogel adhesives help absorb interfacial water, accumulate blood cells or platelets when in contact with blood, enhance blood coagulation ability, accelerate thrombus formation, and promote wound healing. [ 10 ] The CoSt hydrogels demonstrated perfect surface wettability with a contact angle of < 50° at 0 s, as illustrated in Figure S5 (Supporting Information). Moreover, water droplets were promptly sucked in hydrogel within 3 s and vanished from the surface (Movie S1, Supporting Information).…”

“…[ 9 ] Mussels can attach rigorously to various surfaces underwater due to the catechol side chain groups derived from mussel adherent foot proteins can easily interact with various surfaces forming different types of physical (hydrogen bonding, π–π interaction, electrostatic interaction, and coordination) or chemical interactions (Michael addition on reaction). [ 10 ] In the case of underwater adhesion, a hydrated film or cationic hydrated barrier layer will be formed at the adhesion interface, impeding the close contact between the substrate and adhesive. [ 11 ] Mussel adhesion proteins are rich in positively charged structures because of high lysine (Lys) content, and the hydrated membrane or cationic hydrated barrier layer is removed because of the repulsive force of the positive charges.…”

A self-fused hydrogel for the treatment of glottic insufficiency through outstanding durability, extracellular matrix-inducing bioactivity and function preservation

“…The symmetrical vibration of VFs is a prerequisite for phonation [ 37 ]. In this study, the C 2 A 1 , C 1 A 1 and C 1 A 2 hydrogels were injected into the VFs in situ to assess their influence on the vibration capacity of the VFs with a high-speed digital camera system.…”

Robust Natural Polyphenolic Adhesives against Various Harsh Environments

“…As we know, adhesives against various harsh environments not only need great adhesive performances including robust adhesive strength and universal adhesive ability but also require solvent resistance, temperature adaptability, environmentally friendly conditions, etc. In recent years, the adhesion ability of catechol-based adhesives to various surfaces has attracted many attention due to their unique structural and functional features. − Hence, the TA-epoxy adhesive in this study was selected as the model adhesive to compare with several kinds of representative catechol-based adhesives. As shown in Figure a, the adhesive strength between TA-epoxy adhesives and glass was ∼400 KPa, which was weaker than some other kinds of adhesives, such as DETA-CMB, PMB, and PUP-PPG-DBHP adhesives, , but still stronger than many established natural polyphenol-based adhesives. − ,− Although some polyphenolic adhesives provided better performances due to their polymerized structures (i.e., the adhesive strength of DETA-CMB and PMB adhesives was 7–9 MPa and that of PUP-PPG-DBHP adhesives was 800–1200 KPa), , they usually needed multiple components (i.e., paraformaldehyde, amines, and phenols), harmful solvents (i.e., DMSO), long and complex curing process (i.e., 4 h), and expensive raw materials (i.e., the price of p - tert -butylphenol (PTBP) was 26.76 USD/g).…”