Biomimetic Natural Biopolymer‐Based Wet‐Tissue Adhesive for Tough Adhesion, Seamless Sealed, Emergency/Nonpressing Hemostasis, and Promoted Wound Healing

Abstract

Bioadhesives have been used in clinics among the most prospective alternatives to sutures and staples for wound sealing and repairing; however, they generally have inadequate adhesion to wet surfaces, improper mechanical strength, poor hemostasis, and cytotoxicity. To address these challenges, a robust wet tissue adhesive based on collagen and starch materials (CoSt) is designed in this study. CoSt hydrogels integrate the feature of drainage, molecular penetration and strengthen cross-linking similar to mussel, ivy, and oyster glues, which remove interfacial water quickly, reinforce tough dissipation and involve multiple reversible dynamic interactions. Therefore, they form strong adhesion and sutureless sealing of injured tissues, accompanying actuate robust biointerfaces in direct contact with tissue liquids or blood, resolving the crucial impediments with sutures and commercially accessible adhesives. The novel bioadhesive shows repeatable strong wet tissue adhesiveness (62 ± 4.8 KPa), high sealing performance (153.2 ± 35.1 mmHg), fast self-healing ability, excellent injectability, and shape adaptability. For different hemostatic needs in rat models of tail amputation, skin incision, severe liver, abdominal aorta, and transected nerve injuries, the CoSt hydrogel shows better hemostatic efficiency than fibrin glue because of the coordinate efficacy of tough wound sealing property, outstanding red blood cell arresting capability, and the activation of hemostatic barrier membrane. Moreover, in vivo investigation of the skin injury repair of the rat model validate that CoSt hydrogels accelerate wound healing and functional recovery via skin damage/defects. Tough wet adhesion, quick hemostasis, distinguished biocompatibility, suitability to match irregular-shaped target sites, and good wound healing promotion of the CoSt hydrogel makes it a prospective bioadhesive for various biomedical applications.

Injectable, self-healing hydrogel adhesives with firm tissue adhesion and on-demand biodegradation for sutureless wound closure

“…S16). It has been reported that the aggregation of platelets and red blood cells facilitated the formation of a hemostasis barrier ( 57 , 58 ). We further investigated the morphology of hydrogel-treated blood clot by cryo-SEM.…”

Engineered Bicomponent Adhesives with Instantaneous and Superior Adhesion Performance for Wound Sealing and Healing Applications

“…The red star represented LEP‐GA bioadhesive. Numbers 1 to 10 represented LFe‐CMC‐MC, [ 36 ] UIHA, [ 37 ] γ ‐PGA/P‐N/CG15, [ 8 ] Glycopolypeptide, [ 11 ] GelDA/DA–PPy, [ 38 ] LAB2.0, [ 39 ] PFN2H1, [ 15 ] HA‐CNB, [ 1 ] CoSt, [ 40 ] and HPC, [ 41 ] respectively. g) Schematic illustration of the adhesive movement during joint motion.…”

Biomimetic Janus Collagen Patch with Antideformation, Antiadhesion, and Prohealing Properties for Rehabilitation of Full‐Layer Uterine Injuries, Toward Efficient Live Births

“…The uterine leakage model (Figure 3B) was used to evaluate the resistance of the sutured JCOP to fluid leakage. [ 28 ] Leakage of dye was observed in the untreated incision after injection of 2 mL of blue dye. However, in the JCOP group, no significant fluid leakage was observed (Figure 3B).…”