Bioactive and superabsorbent cellulosic dressing grafted alginate and Carthamus tinctorius polysaccharide extract for the treatment of chronic wounds

Abstract

Diabetic foot ulcers have a negative impact on the lives of patients and are highly vulnerable to infection, leading to amputation too often. It is essential that the patient with a diabetic foot ulcer receives the best possible care. Herein, we developed a new functionalized cellulosic wound dressing with high-improved healing properties, able to be a serious alternative for diabetic acute wounds. First, a bioactive polysaccharide was extracted from the Carthamus tinctorius plant. Then a new crosslinked polymer-based alginate/ C. tinctorius polymer extract was prepared and checked for combined antimicrobial and tissue regeneration properties. Afterward, the efficiency of the textile functionalization process was optimized through studying the influence of different grafting parameters: curing conditions and the concentration of the impregnating solution. The drop method wettability technique exhibited significant improvement in the hydrophilicity behavior of treated textile samples, which increased with the grafting rate. Attenuated total reflection Fourier-transform infrared spectroscopy and thermogravimetric analysis or differential thermal analysis were investigated to test whether the chemical permanent grafting resisted the severe standard washing conditions. The tensile strength characteristics showed that the grafting does not affect the original mechanical properties of treated textile dressings. A morphological study via scanning electron microscopy images confirmed the permanent textile finishing performance and permitted us to assess its chemical grafting approach onto the treated surfaces. The biological and the bacteriological investigations of functionalized dressings proved that the functional biomaterial could be used as a medical bioactive device with improved biological properties.

Design and Evaluation of a New Natural Multi-Layered Biopolymeric Adsorbent System-Based Chitosan/Cellulosic Nonwoven Material for the Biosorption of Industrial Textile Effluents

“…Figure 9b showed the variation of the adsorption capacity as a function of the temperature for a dye concentration of 600 mg L −1 and a contact time of 120 min. The variation in adsorption capacity showed the same trend for the three varied temperatures (22,40, and 60 • C). The recorded decrease in adsorption performance with the gradual increase in temperature revealed that the interaction between the PEM adsorbent and the reactive anionic dye was exothermic.…”

“…The PEM material finished with 5 layers presented a more hydrophilic capacity with nearly a 3-fold swelling ratio. This was due the hydrophilic character of the chitosan bio-polymer and its reticulated polymer functionalizing the cellulosic material which is also known by its good hydrophilicity [38][39][40]. The functionalization using natural hydrophilic biopolymers upon layer-by-layer deposition technique provided excellent hydrophilic structure with higher water penetration volume, which is a required property for improved adsorption capacity.…”

Recent Advances in Functional Polymer Materials for Energy, Water, and Biomedical Applications: A Review

“…Actually, bioactive natural polymers, such as chitosan, alginate, carrageenan, and various polysaccharide extracts from plants were grafted onto various textile biomaterials, including implants and wound dressings. Successful chemical grafting without altering the different mechanical, swelling, and microbiological properties of the grafted biopolymers afforded excellent and promising functionalized textile biomaterials with enhanced physical, bacterial, and biological performance [195][196][197][198][199][200][201][202][203][204][205][206][207][208].…”

Preparation and Characterization of a New Polymeric Multi-Layered Material Based K-Carrageenan and Alginate for Efficient Bio-Sorption of Methylene Blue Dye

“…Cellulose, alginates, and k-carrageenan biopolymers were naturally abundant polysaccharides. Cellulose is recognized for its good hydrophilicity [ 16 , 17 , 18 , 19 , 20 , 21 ]. Alginate, a polysaccharide biopolymer, is an essential component of the cell wall of brown algae.…”