Improvement of mechanical properties of macroporous β-tricalcium phosphate bioceramic scaffolds with uniform and interconnected pore structures

Leveraging “Raw Materials” as Building Blocks and Bioactive Signals in Regenerative Medicine

“…Lin et al 131 found that nanoscale b-TCP ceramics degraded slower than those fabricated from microscale powders. Further, ceramics made from nanoscale b-TCP had twice the mechanical strength of those fabricated from microscale powder, and the nanoscale b-TCP ceramic reached a compressive strength in the upper range of native cancellous bone.…”

“…Further, ceramics made from nanoscale b-TCP had twice the mechanical strength of those fabricated from microscale powder, and the nanoscale b-TCP ceramic reached a compressive strength in the upper range of native cancellous bone. 131 The combination of mechanical properties and fast resorption of b-TCP made from nanoscale powder provides tissue engineers another attractive bioceramic formulation option. Another group investigated granule size and morphology of b-TCP granules in a subcutaneous rat model ( Table 2) and found that the greatest vascularization occurred in the group with polygonal morsel-shaped granules ranging from 63 to 250 microns in size.…”

Evaluation of physical and mechanical properties of B-tri-calcium phosphate/poly-3-hydroxybutyrate nanocomposite scaffold for bone tissue engineering application

“…This property imparts signi cant advantage to -TCP compared to other bioceramics, which are not resorbed and replaced by newformed bone tissues [25]. Therefore, -TCP bioceramics are extensively used in bone lling substituted in the eld of oral plastic surgery and bone tissue engineering sca olds [25]. Based on previous studies, a desired sca old for bone engineering should comply with a number of mechanical and physiological demands:…”

“…This material was tested in vivo with good results without the need for a second surgical operation to remove the device after healing occurrence [6]. This property imparts signi cant advantage to -TCP compared to other bioceramics, which are not resorbed and replaced by newformed bone tissues [25]. Therefore, -TCP bioceramics are extensively used in bone lling substituted in the eld of oral plastic surgery and bone tissue engineering sca olds [25].…”

Strontium Incorporation on Microspheres of Alginate/β-tricalcium Phosphate as Delivery Matrices

“…Among the various calcium phosphate ceramics, β-tricalcium phosphate (β-Ca 3 (PO 4 ) 2 , β-TCP) is considered a suitable candidate as a synthetic bone graft and cement, due to the notable biocompatibility and its compositional similarities to human bones 2 . Besides that, the dissolution rate of β-TCP is faster than other biomedical ceramics 3 .…”