Evaluation of physical and mechanical properties of B-tri-calcium phosphate/poly-3-hydroxybutyrate nanocomposite scaffold for bone tissue engineering application

Abstract

KEYWORDSNano--tricalcium phosphate ( -TCP); Poly-3-hydroxybutyrate (P3HB); Sca old; Tissue engineering.Abstract. One of the major challenges facing researchers of tissue engineering is the sca old design with desirable physical and mechanical properties for growth and proliferation of cells and tissue formation. In this paper, rstly, -tricalcium phosphate ( -TCP) nanopowders with particle size of 50-70 nm were synthesized using a simple sol-gel route with calcium nitrate and potassium dihydrogenphosphate as calcium and phosphorus precursors, respectively. Then, the porous ceramic sca old containing 40, 50, and 60 wt% of n -TCP was prepared by the polyurethane sponge replication method. The sca olds were coated with P3HB for 30 sec and 1 min in order to increase the sca old's mechanical properties. XRD, XRF, SEM, TEM, and FT-IR were used in order to study the phase and element structure, morphology, particle size, and determination of functional groups, respectively. Based on the results of compressive strength and porosimetry tests, the most appropriate type of sca old is 50 wt% of n -TCP immersed for 30 sec in P3HB with 75% porosity in 200-600 m, with a compressive strength of 1.09 MPa and a compressive modulus of 33 MPa, which can be utilized in bone tissue engineering.

Coating of B2O3 and Al2O3 containing Hydroxyapatite on Ti6Al4V by HVOF Technique

“…CaPs, in particular hydroxyapatite (HA), are often used in the coating of metals to o er the biocompatibility and mechanical strength of both types of materials. The thickness of HA coating is very important [6,7]. Teng et al studied Sr-substituted hydroxyapatite (Sr-HA) coatings on Ti metal.…”

In vivo evaluation of bone regeneration behavior of novel β‐tricalcium phosphate/layered double hydroxide nanocomposite granule as bone graft substitutes

“…Several studies have demonstrated that the mechanical strength of CaP materials can be improved by using a suitable reinforcing phase such as biocompatible nanoparticles. 10,11 It was observed that graphene oxide (GO) nanoparticles remarkably enhance proliferation and osteogenesis when applied as a coating over the ß-TCP and can enhance the osteogenesis process in vivo. These fabricated scaffolds hold immense advantages and potential for bone healing applications, mainly for the large-area osseous defects reconstruction.…”