Improved vascularisation but inefficient in vivo bone regeneration of adipose stem cells and poly-3-hydroxybutyrate-co-3-hydroxyvalerate scaffolds in xeno-free conditions

Paula, Alessandro Vinícius de; Carvalho, Pablo Herthel de; Martins, Thaís M.M.; Boeloni, Jankerle Neves; Cunha, Pricila S.; Novikoff, Silviene; Correlo, Vítor M.; Reis, Rui L.; Góes, Alfredo M.

doi:10.1016/j.msec.2019.110301

Cited by 7 publications

(1 citation statement)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polyhydroxyalkanoates, another commonly used biodegradable piezoelectric polymer, are aliphatic copolyesters with varying structures that are synthesized by microorganisms [ 98 ]. Polyhydroxyalkanoates include polyhydroxybutyrate (PHB) and poly(3-hydroxybutyrate-3-hydroxyvalerate) (PHBV) [ 99 ].…”

Section: Reviewmentioning

confidence: 99%

From electricity to vitality: the emerging use of piezoelectric materials in tissue regeneration

Wu,

Zou,

Tang

et al. 2024

Burns &Amp; Trauma

View full text Add to dashboard Cite

The unique ability of piezoelectric materials to generate electricity spontaneously has attracted widespread interest in the medical field. In addition to the ability to convert mechanical stress into electrical energy, piezoelectric materials offer the advantages of high sensitivity, stability, accuracy and low power consumption. Because of these characteristics, they are widely applied in devices such as sensors, controllers and actuators. However, piezoelectric materials also show great potential for the medical manufacturing of artificial organs and for tissue regeneration and repair applications. For example, the use of piezoelectric materials in cochlear implants, cardiac pacemakers and other equipment may help to restore body function. Moreover, recent studies have shown that electrical signals play key roles in promoting tissue regeneration. In this context, the application of electrical signals generated by piezoelectric materials in processes such as bone healing, nerve regeneration and skin repair has become a prospective strategy. By mimicking the natural bioelectrical environment, piezoelectric materials can stimulate cell proliferation, differentiation and connection, thereby accelerating the process of self-repair in the body. However, many challenges remain to be overcome before these concepts can be applied in clinical practice, including material selection, biocompatibility and equipment design. On the basis of the principle of electrical signal regulation, this article reviews the definition, mechanism of action, classification, preparation and current biomedical applications of piezoelectric materials and discusses opportunities and challenges for their future clinical translation.

show abstract

Section: Reviewmentioning

confidence: 99%

From electricity to vitality: the emerging use of piezoelectric materials in tissue regeneration

Wu,

Zou,

Tang

et al. 2024

Burns &Amp; Trauma

View full text Add to dashboard Cite

show abstract

Bioactive polymeric scaffolds for osteogenic repair and bone regenerative medicine

Amiryaghoubi

Fathi

Pesyan

et al. 2020

Medicinal Research Reviews

View full text Add to dashboard Cite

The loss of bone tissue is a striking challenge in orthopedic surgery. Tissue engineering using various advanced biofunctional materials is considered a promising approach for the regeneration and substitution of impaired bone tissues. Recently, polymeric supportive scaffolds and biomaterials have been used to rationally promote the generation of new bone tissues. To restore the bone tissue in this context, biofunctional polymeric materials with significant mechanical robustness together with embedded materials can act as a supportive matrix for cellular proliferation, adhesion, and osteogenic differentiation. The osteogenic regeneration to replace defective tissues demands greater calcium deposits, high alkaline phosphatase activity, and profound upregulation of osteocalcin as a late osteogenic marker. Ideally, the bioactive polymeric scaffolds (BPSs) utilized for bone tissue engineering should impose no detrimental impacts and function as a carrier for the controlled delivery and release of the loaded molecules necessary for the bone tissue regeneration. In this review, we provide comprehensive insights into different synthetic and natural polymers used for the regeneration of bone tissue and discuss various technologies applied for the engineering of BPSs and their physicomechanical properties and biological effects.

show abstract

Future Directions and Requirements for Tissue Engineering Biomaterials

Arjunan

Baroutaji

Robinson

et al. 2022

Encyclopedia of Smart Materials

View full text Add to dashboard Cite

Improved vascularisation but inefficient in vivo bone regeneration of adipose stem cells and poly-3-hydroxybutyrate-co-3-hydroxyvalerate scaffolds in xeno-free conditions

Cited by 7 publications

References 55 publications

From electricity to vitality: the emerging use of piezoelectric materials in tissue regeneration

From electricity to vitality: the emerging use of piezoelectric materials in tissue regeneration

Bioactive polymeric scaffolds for osteogenic repair and bone regenerative medicine

Future Directions and Requirements for Tissue Engineering Biomaterials

Contact Info

Product

Resources

About