Bioactive polymeric scaffolds for osteogenic repair and bone regenerative medicine

Amiryaghoubi, Nazanin; Fathi, Marziyeh; Pesyan, Nader Noroozi; Samiei, Mohammad; Barar, Jaleh; Omidi, Yadollah

doi:10.1002/med.21672

Cited by 79 publications

(35 citation statements)

References 201 publications

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“…In that way, the composition and structure of inorganic and organic bone matrix may directly affect bone quality [ 13 ] and determine the fate of the progenitors of bone cells. Different strategies to closely mimic the bone microenvironment focus on adding bioactive factors to scaffolds [ 62 , 63 ]; as surface modification of scaffolds or via the addition of bioactive molecules and drugs that regulate bone tissue homeostasis.…”

Section: Strategies Promoting Bone Healing Through An Endogenous Responsementioning

confidence: 99%

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Macías

Alcorta-Sevillano

Infante

et al. 2021

IJMS

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Bone damage leading to bone loss can arise from a wide range of causes, including those intrinsic to individuals such as infections or diseases with metabolic (diabetes), genetic (osteogenesis imperfecta), and/or age-related (osteoporosis) etiology, or extrinsic ones coming from external insults such as trauma or surgery. Although bone tissue has an intrinsic capacity of self-repair, large bone defects often require anabolic treatments targeting bone formation process and/or bone grafts, aiming to restore bone loss. The current bone surrogates used for clinical purposes are autologous, allogeneic, or xenogeneic bone grafts, which although effective imply a number of limitations: the need to remove bone from another location in the case of autologous transplants and the possibility of an immune rejection when using allogeneic or xenogeneic grafts. To overcome these limitations, cutting edge therapies for skeletal regeneration of bone defects are currently under extensive research with promising results; such as those boosting endogenous bone regeneration, by the stimulation of host cells, or the ones driven exogenously with scaffolds, biomolecules, and mesenchymal stem cells as key players of bone healing process.

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Section: Strategies Promoting Bone Healing Through An Endogenous Responsementioning

confidence: 99%

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Macías

Alcorta-Sevillano

Infante

et al. 2021

IJMS

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“…136 Furthermore, studies have shown that physical properties of the scaffold are very important and can affect bone regeneration. [137][138][139][140] These physical properties can also be optimized by ZnO-NPs modifications. Sahmani et al 93 mixed different proportions of ZnO-NPs with HA, then sintered the mixed materials, and coated the resulting scaffolds with gelatin-ibuprofen.…”

Section: Dovepressmentioning

confidence: 99%

<p>Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review</p>

Li¹,

Yang²,

Qing³

et al. 2020

IJN

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Prosthesis-associated infections and aseptic loosening are major causes of implant failure. There is an urgent need to improve the antibacterial ability and osseointegration of orthopedic implants. Zinc oxide nanoparticles (ZnO-NPs) are a common type of zinccontaining metal oxide nanoparticles that have been widely studied in many fields, such as food packaging, pollution treatment, and biomedicine. The ZnO-NPs have low toxicity and good biological functions, as well as antibacterial, anticancer, and osteogenic capabilities. Furthermore, ZnO-NPs can be easily obtained through various methods. Among them, green preparation methods can improve the bioactivity of ZnO-NPs and strengthen their potential application in the biological field. This review discusses the antibacterial abilities of ZnO-NPs, including mechanisms and influencing factors. The toxicity and shortcomings of anticancer applications are summarized. Furthermore, osteogenic mechanisms and synergy with other materials are introduced. Green preparation methods are also briefly reviewed.

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“…Scaffolds are three-dimensional porous structures playing a pivotal role in regenerative medicine and tissue engineering for the repair of tissue and organs [36,37]. Different materials, both synthetized and printed, are suitable for cell culture and sustaining the development of native tissue [38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Chitosan-Hydrogel Polymeric Scaffold Acts as an Independent Primary Inducer of Osteogenic Differentiation in Human Mesenchymal Stromal Cells

Bernardi

Bosio

et al. 2020

Materials

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Regenerative medicine aims to restore damaged tissues and mainly takes advantage of human mesenchymal stromal cells (hMSCs), either alone or combined with three-dimensional scaffolds. The scaffold is generally considered a support, and its contribution to hMSC proliferation and differentiation is unknown or poorly investigated. The aim of this study was to evaluate the capability of an innovative three-dimensional gelatin–chitosan hybrid hydrogel scaffold (HC) to activate the osteogenic differentiation process in hMSCs. We seeded hMSCs from adipose tissue (AT-hMSCs) and bone marrow (BM-hMSCs) in highly performing HC of varying chitosan content in the presence of growing medium (GM) or osteogenic medium (OM) combined with Fetal Bovine Serum (FBS) or human platelet lysate (hPL). We primarily evaluated the viability and the proliferation of AT-hMSCs and BM-hMSCs under different conditions. Then, in order to analyse the activation of osteogenic differentiation, the osteopontin (OPN) transcript was absolutely quantified at day 21 by digital PCR. OPN was expressed under all conditions, in both BM-hMSCs and AT-hMSCs. Cells seeded in HC cultured with OM+hPL presented the highest OPN transcript levels, as expected. Interestingly, both BM-hMSCs and AT-hMSCs cultured with GM+FBS expressed OPN. In particular, BM-hMSCs cultured with GM+FBS expressed more OPN than those cultured with GM+hPL and OM+FBS; AT-hMSCs cultured with GM+FBS presented a lower expression of OPN when compared with those cultured with GM+hPL, but no significant difference was detected when compared with AT-hMSCs cultured with OM+FBS. No OPN expression was detected in negative controls. These results show the capability of HC to primarily and independently activate osteogenic differentiation pathways in hMCSs. Therefore, these scaffolds may be considered no more as a simple support, rather than active players in the differentiative and regenerative process.

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Bioactive polymeric scaffolds for osteogenic repair and bone regenerative medicine

Cited by 79 publications

References 201 publications

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

<p>Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review</p>

Chitosan-Hydrogel Polymeric Scaffold Acts as an Independent Primary Inducer of Osteogenic Differentiation in Human Mesenchymal Stromal Cells

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