Future Directions and Requirements for Tissue Engineering Biomaterials

Arjunan, Arun; Baroutaji, Ahmad; Robinson, John; Praveen, Ayyappan Susila; Pollard, Andrew J.; Wang, Chang

doi:10.1016/b978-0-12-815732-9.00068-1

Cited by 15 publications

(10 citation statements)

References 239 publications

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“…AM such as SLM is already being used in the biomedical industry and is widely considered the key enabling technology for the future of personalised medicine. Although significant progress has been made in the arena of 3D printed biomedical products, the regulatory process is still evolving (Ngo et al, 2018;Arjunan et al, 2021c;Arjunan et al, 2021d). However, it is hopeful that Class I devices such as the ones demonstrated in this study can be approved through an existing well-established process.…”

Section: Regulation and Approvalmentioning

confidence: 96%

Additive manufacturing of anti-SARS-CoV-2 Copper-Tungsten-Silver alloy

Robinson

Arjunan

Baroutaji

et al. 2021

RPJ

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Purpose The COVID-19 pandemic emphasises the need for antiviral materials that can reduce airborne and surface-based virus transmission. This study aims to propose the use of additive manufacturing (AM) and surrogate modelling for the rapid development and deployment of novel copper-tungsten-silver (Cu-W-Ag) microporous architecture that shows strong antiviral behaviour against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Design/methodology/approach The research combines selective laser melting (SLM), in-situ alloying and surrogate modelling to conceive the antiviral Cu-W-Ag architecture. The approach is shown to be suitable for redistributed manufacturing by representing the pore morphology through a surrogate model that parametrically manipulates the SLM process parameters: hatch distance (h_d), scan speed (S_s) and laser power (L_p). The method drastically simplifies the three-dimensional (3D) printing of microporous materials by requiring only global geometrical dimensions solving current bottlenecks associated with high computed aided design data transfer required for the AM of porous materials. Findings The surrogate model developed in this study achieved an optimum parametric combination that resulted in microporous Cu-W-Ag with average pore sizes of 80 µm. Subsequent antiviral evaluation of the optimum architecture showed 100% viral inactivation within 5 h against a biosafe enveloped ribonucleic acid viral model of SARS-CoV-2. Research limitations/implications The Cu-W-Ag architecture is suitable for redistributed manufacturing and can help reduce surface contamination of SARS-CoV-2. Nevertheless, further optimisation may improve the virus inactivation time. Practical implications The study was extended to demonstrate an open-source 3D printed Cu-W-Ag antiviral mask filter prototype. Social implications The evolving nature of the COVID-19 pandemic brings new and unpredictable challenges where redistributed manufacturing of 3D printed antiviral materials can achieve rapid solutions. Originality/value The papers present for the first time a methodology to digitally conceive and print-on-demand a novel Cu-W-Ag alloy that shows high antiviral behaviour against SARS-CoV-2.

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Section: Regulation and Approvalmentioning

confidence: 96%

Additive manufacturing of anti-SARS-CoV-2 Copper-Tungsten-Silver alloy

Robinson

Arjunan

Baroutaji

et al. 2021

RPJ

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“…Following the recent advancements in bone regeneration scaffolds, substantial interest is now growing towards designing multifunctional scaffolds loaded with various molecules and nanomaterials for advanced bone regeneration scaffolds ( Figure 7 ) ( Arjunan et al, 2021 ). For example, in addition to other biofactors and biomolecules, nucleic acids can be added to encode the growth factors that promote bone growth.…”

Section: Future Workmentioning

confidence: 99%

Bioactive glass-collagen/poly (glycolic acid) scaffold nanoparticles exhibit improved biological properties and enhance osteogenic lineage differentiation of mesenchymal stem cells

Toosi

Naderi‐Meshkin

Esmailzadeh

et al. 2022

Front. Bioeng. Biotechnol.

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Today’s using tissue engineering and suitable scaffolds have got attention to increase healing of non-union bone fractures. In this study, we aimed to prepare and characterize scaffolds with functional and mechanical properties suitable for bone regeneration. Porous scaffolds containing collagen-poly glycolic acid (PGA) blends and various quantities of bioactive glass (BG) 45S5 were fabricated. Scaffolds with different compositions (BG/collagen-PGA ratios (w/w): 0/100; 40/60; 70/30) were characterized for their morphological properties, bioactivity, and mechanical behavior. Then, biocompatibility and osteogenic differentiation potential of the scaffolds were analyzed by seeding mesenchymal stem cells (MSCs). Scaffolds made with collagen-PGA combined with the BG (45S5) were found to have interconnected pores (average pore diameter size 75–115 µm) depending on the percentage of the BG added. Simulated body fluid (SBF) soaking experiments indicated the stability of scaffolds in SBF regardless of their compositions, while the scaffolds retained their highly interconnected structure. The elastic moduli, cell viability, osteogenic differentiation of the BG/collagen-PGA 40/60 and 70/30 scaffolds were superior to the original BG/collagen-PGA (0/100). These results suggest that BG incorporation enhanced the physical stability of our collagen-PGA scaffold previously reported. This new scaffold composition provides a promising platform to be used as a non-toxic scaffold for bone regeneration and tissue engineering.

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“…Among these, the GBR, which has the aim of improving and guiding the mechanism of bone repair, requires scaffold materials with a three-dimensional structure, similar to the extracellular matrix. Biomaterials are a class of materials, characterized by unique chemical, mechanical and biological properties, mainly osteoinductivity and osteoconductivity, which make them suitable and safe to interact with living tissue [ 3 , 4 ]. The first application of biomaterials was during the 1950s, but only in the 1970s was there an onset of the second generation of materials, for human tissue replacement, and their evolution induced a significant impact on regenerative medicine [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Proliferation and Morphological Assessment of Human Periodontal Ligament Fibroblast towards Bovine Pericardium Membranes: An In Vitro Study

et al. 2022

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Over the past decade regenerative branches of dentistry have taken on more and more importance, resulting in the development of performing scaffold materials. These should induce cell adhesion, support, and guide the tissues’ growth. Among the developed materials, we can include resorbable or non-membranes. The purpose of this study was to investigate the proliferation abilities and the attachment of human periodontal ligament fibroblasts (HPLIFs) over two bovine pericardium membranes with different thicknesses, 0.2 mm and 0.4 mm, respectively. These membranes have been decellularized by the manufacturer, preserving the three-dimensional collagen’s structure. The HPLFs were cultured in standard conditions and exposed to the tested materials. XTT was performed to assess cell proliferation, while light microscopy (LM) and scanning electron microscopy (SEM) observations assessed fibroblast morphology at different times (T1, T2, and T3). Proliferation assays have shown a statistically significant difference in growth at T1 (p < 0.05) in the cells cultured with a thicker membrane compared to the thinner one. LM analysis showed healthy fibroblasts in contact with the membranes, appearing larger and with a polygonal shape. SEM observation demonstrated thickening of the fibroblasts which continued to adhere to the membrane’s surface, with enlarged polygonal shape and developed filipodia and lamellipodia. These results showed a similar cell behavior over the two bovine pericardium membranes, demonstrating a cellular migration along and within the layers of the membrane, binding with membrane fibers by means of filopodial extensions. Knowledge of the effects of the collagen membranes derived from bovine pericardium on cellular behavior will help clinicians choose the type of scaffolds according to the required clinical situation.

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Future Directions and Requirements for Tissue Engineering Biomaterials

Cited by 15 publications

References 239 publications

Additive manufacturing of anti-SARS-CoV-2 Copper-Tungsten-Silver alloy

Additive manufacturing of anti-SARS-CoV-2 Copper-Tungsten-Silver alloy

Bioactive glass-collagen/poly (glycolic acid) scaffold nanoparticles exhibit improved biological properties and enhance osteogenic lineage differentiation of mesenchymal stem cells

Proliferation and Morphological Assessment of Human Periodontal Ligament Fibroblast towards Bovine Pericardium Membranes: An In Vitro Study

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