Impact of stent strut design in metallic stents and biodegradable scaffolds

Foin, Nicolas; Lee, Renick D.; Torii, Ryo; Guitierrez-Chico, Juan Luis; Mattesini, Alessio; Nijjer, Sukhjinder; Sen, Sayan; Petraco, Ricardo; Davies, Justin E.; Mario, Carlo Di; Joner, Michael; Virmani, Renu; Wong, Philip

doi:10.1016/j.ijcard.2014.09.143

Cited by 141 publications

(82 citation statements)

References 74 publications

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“…Stent restenosis and thrombosis are less frequent with the new‐generation DES but are still considered major complications . Each stent is associated with specific biomechanical characteristics that may be related to definite benefits and/or complications . Stent deformation or damage induced by specific angioplasty procedures may contribute to restenosis .…”

Section: Introductionmentioning

confidence: 99%

Standardized bench test evaluation of coronary stents: Biomechanical characteristics

Bonin

Guérin

Olive

et al. 2018

Cathet Cardio Intervent

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Objectives: The purpose of the study was to develop a standardized and global bench test protocol to evaluate the biomechanical characteristics of the most currently used drug-eluting coronary stents.Background: The use of coronary stents has contributed to the reduction of cardiovascular mortality but can be associated with specific complications. Improving the biomechanical matching between the stents and the coronary anatomy may reduce these complications. Methods:We assessed five commercially available drug-eluting stents: the Absorb, Orsiro, Resolute Onyx, Synergy, and Xience Alpine stents. Following stent deployment at nominal pressure in ambient air, radial elastic recoil and foreshortening were measured. Flexibility (crimped and deployed stents) and longitudinal and radial resistances were evaluated using a mechanical tester.Results: Biomechanical characteristics were significantly different for all tested devices (ANOVA, P < 0.01). The Synergy, Orsiro, and Xience Alpine stents presented the lowest elastic recoil. The Synergy and Resolute Onyx stents were the most flexible devices. The Xience Alpine and Absorb stents had the highest longitudinal and radial resistances.Conclusions: Drug-eluting coronary stents used in current clinical practice have very different biomechanical characteristics, which should be taken into consideration to select the most appropriate device for each clinical situation. K E Y W O R D Sbench test, biomechanical performance, scoronary stents

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Section: Introductionmentioning

confidence: 99%

Standardized bench test evaluation of coronary stents: Biomechanical characteristics

Bonin

Guérin

Olive

et al. 2018

Cathet Cardio Intervent

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“…Polybutylene Succinate (PBS) is one of the newest biopolymers under development, and belongs to biodegradable aliphatic polyester. It has high crystallinity, a melting point of about 90°C 120°C and a glass transition temperature of around −45~−10°C (Foin et al 2014;Papageorgiou et al 2007). Moreover, PBS has good material processability, even better than PLA, and can be easily processed at relatively low cost as compared with other biodegradable polymers (Kanemura et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Testing, characterization and modelling of mechanical behaviour of poly (lactic-acid) and poly (butylene succinate) blends

Qiu

Song

Zhao

2016

Mech Adv Mater Mod Process

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Background: Significant amount of research, both experimental and numerical, has been conducted to study the mechanical behaviour of biodegradable polymer PL(L)A due to its wide range of applications. However, mechanical brittleness or poor elongation of PL(L)A has limited its applications considerably, particularly in the biomedical field. This study aims to study the potential in improving the ductility of PLA by blending with PBS in varied weight ratios. Methods: The preparation of PLA and PBS blends, with various weight ratios, was achieved by melting and mixing technique at high temperature using HAAKE™ Rheomix OS Mixer. Differential Scanning Calorimetry (DSC) was applied to investigate the melting behaviour, crystallization and miscibility of the blends. Small dog-bone specimens, produced by compression moulding, were used to test mechanical properties under uniaxial tension. Moreover, an advanced viscoplastic model with nonlinear hardening variables was applied to simulate ratedependent plastic deformation of PLA/PBS blends, with model parameters calibrated simultaneously against the tensile test data. Results: Optical Microscopy showed that PBS composition aid with the crystallization of PLA. The elongation of PLA/PBS blends increased with the increase of PBS content, but with a compromise of tensile modulus and strength. An increase of strain rate led to enhanced stress response, demonstrating the time-dependent deformation nature of the material. Model simulations of time-dependent plastic deformation for PLA/PBS blends compared well with experimental results. Conclusions: The crystallinity of PLA/PBS blends increased with the addition of PBS content. The brittleness of pure PLA can be improved by blending with ductile PBS using mechanical mixing technique, but with a loss of stiffness and strength. The tensile tests at different strain rates confirmed the time-dependent plastic deformation nature of the blends, i.e., viscoplasticity, which can be simulated by the Chaboche viscoplastic model with nonlinear hardening variables.

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“…3 8 Je geringer die Zahl der "Hinge"-Regionen im Stent (kleine Kreise), umso größer die Stentflexibilität und umso geringer der Intimaschaden bei Implantation. (Aus Foin et al [46], mit freundl. Genehmigung von Elsevier)…”

Section: Der Trend Geht Zu Immer Dünneren Stentstrebenunclassified

Moderne Koronarstents und „vascular scaffolds“

Gielen

Haude

Tebbe

et al. 2016

Z Herz- Thorax- Gefäßchir

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Diese Fortbildungseinheit steht Ihnen als e.CME und e.Tutorial in der Springer Medizin e.Akademie zur Verfügung. -e.CME: kostenfreie Teilnahme im Rahmen des jeweiligen Zeitschriftenabonnements -e.Tutorial: Teilnahme im Rahmen des e.Med-Abonnements ZertifizierungDiese Fortbildungseinheit ist mit 3 CMEPunkten zertifiziert von der Landesärzte-kammer Hessen und der Nordrheinischen Akademie für Ärztliche Fort-und Weiterbildung und damit auch für andere Ärzte-kammern anerkennungsfähig. Hinweis für Leser aus ÖsterreichGemäß dem Diplom-Fortbildungs-Programm (DFP) der Österreichischen Ärzte-kammer werden die in der e.Akademie erworbenen CME-Punkte hierfür 1:1 als fachspezifische Fortbildung anerkannt. ZusammenfassungSeit Grüntzigs erster Ballonangioplastie 1977 haben 3 Innovationen in der perkutanen Koronarintervention deren Akut-und Langzeitergebnisse dramatisch verbessert: Einfüh-rung der Koronarstents zur Beherrschung der dilatationsbedingten Dissektionen, Einfüh-rung der medikamentenbeschichteten Stents zur Reduktion der In-Stent-Restenose und duale Plättchenhemmung zur Vermeidung der Stentthrombose. Fortschritte im Stent-Design, resorbierbare Polymere und neue antiproliferative Wirkstoffe tragen zur Reduktion von Stentthrombosen und In-Stent-Restenose bei. Mithilfe bioresorbierbarer Stents ("scaffolds") werden die Nachteile klassischer nichtresorbierbarer metallbasierter Stents (u. a. erschwerte spätere Bypassversorgung, Artefakte bei CT/MRT) zunehmend überwunden. Die Indikationsstellung zur interventionellen vs. operativen Revaskularisation wird angesichts neuer Techniken und innovativer interventioneller Methoden/Stentsysteme ständig evidenzbasiert neu in den Leitlinien definiert werden müssen. Schlüsselwörter Resorbierbare Implantate · Medikamentenbeschichtete Stents · unbeschichtete Stents · Equipment-Design · Angioplastie, Ballon Zeitschrift für Herz-, Thorax-und Gefäßchirurgie 2 · 2016 97 CME Lernziele Nach der Lektüre dieses Beitrags ... 4 kennen Sie die historische Entwicklung der modernen Koronarinterventionen. 4 verstehen Sie die Unterschiede zwischen unbeschichteten Metallstents ("bare metal stent", BMS) einerseits und den verschiedenen Formen der medikamentenbeschichteten Stents ("drug eluting stent", DES) andererseits. 4 können Sie die Unterschiede zwischen polymerbeschichteten und -freien Stents im Hinblick auf Medikamentenfreisetzung und Thromboserate beschreiben. 4 kennen Sie aktuelle bioresorbierbare Stents und die Möglichkeiten ihrer klinischen Anwendung. 4 wissen Sie um die Anwendungsmöglichkeiten der medikamentenbeschichteten Ballons ("drug-eluting balloon", DEB). Hintergrund Seit der ersten perkutanen transluminalen Koronarangioplastie (PTCA) durch Andreas Grüntzig in Zürich 1977 hat sich das Feld der perkutanen koronaren Interventionen ("percutaneous coronary intervention", PCI) dynamisch entwickelt. Dies betrifft sowohl die Breite der Anwendung als auch die Komplexität der Differenzialtherapie mit den zur Verfügung stehenden Interventionstechniken und Stentsystemen. Die Analyse DeutscherHerzber...

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Impact of stent strut design in metallic stents and biodegradable scaffolds

Cited by 141 publications

References 74 publications

Standardized bench test evaluation of coronary stents: Biomechanical characteristics

Standardized bench test evaluation of coronary stents: Biomechanical characteristics

Testing, characterization and modelling of mechanical behaviour of poly (lactic-acid) and poly (butylene succinate) blends

Moderne Koronarstents und „vascular scaffolds“

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