Impact of Metabolic Syndrome on Benign Prostatic Hyperplasia in Elderly Chinese Men

Abstract

Objective: The aim of the present study was to evaluate the impact of metabolic syndrome (MetS) on benign prostatic hyperplasia (BPH) in elderly Chinese men. Methods: A total of 401 elderly BPH patients were divided into the without or with MetS group to assess the associations of MetS and components of MetS with BPH. Urologic evaluation included prostate volume, International Prostate Symptom Score, serum prostate-specific antigen, duration of concomitant lower urinary tract symptoms (LUTS) and maximum flow rate. Results: Body mass index (BMI), waist circumference, fasting glucose, glycosylated hemoglobin, triglyceride, fasting insulin (FINS), insulin resistance assessed by homeostasis model assessment (HOMA-IR) were greater and high-density lipoprotein cholesterol (HDL-C) was lower in BPH patients with MetS than in those without MetS. The patients with MetS showed a significantly larger prostate volume (p = 0.000) and longer duration of LUTS (p = 0.006) than those without MetS. Prostate volume was positively correlated with BMI (p = 0.000), FINS (p = 0.001), HOMA-IR (p = 0.003) and inversely correlated with HDL-C (p = 0.000). Multiple linear regression analysis showed that prostate volume was significantly correlated with HOMA-IR (p = 0.015). Conclusions: Our results suggest that MetS, BMI, low HDL-C level, increased serum insulin and especially insulin resistance are considered risk factors for prostate enlargement in elderly Chinese men.

The Relationship between the Clinical Progression of Benign Prostatic Hyperplasia and Metabolic Syndrome: A Prospective Study

“…In a retrospective study that involved 1,052 men aged 51-84, Pan et al [17] reported that MetS was associated with annual prostate growth rate and total PV. Zhang et al [18] also found that the presence of MetS was a risk factor for the enlarged prostate.…”

Transitional Zone Index as a Predictor of the Efficacy of α-Blocker and 5α-Reductase Inhibitor Combination Therapy in Korean Patients with Benign Prostatic Hyperplasia

“…The etiology of BPH has intrigued researchers in various fields of medicine. Some of them suggested that metabolic syndrome is significantly associated with the development of BPH [3,4]. BPE usually involves the hypertrophy of all elements of prostate.…”

The role of estrogens at men. Part 2. Private clinical endocrinology and pathophysiology of estrogens at men

“…Наличие ме-таболического синдрома связано с достоверно боль-шим общим объемом предстательной железы и боль-шей медианой ежегодного прироста ее переходной зоны, а также с достоверно более высоким уровнем простатспецифического антигена в крови, который может считаться, по мнению ряда авторов, индексом простатического объема и критерием выраженности СНМП [55][56][57][58][59]. Сегодня ДГПЖ рассматривается как системное гормонально-метаболическое заболевание, в основе патогенеза которого лежат дислипидемия, хроническое воспаление и нарушение соотношения тестостерон/эстрадиол [60][61][62][63].…”