Current review provides a multifaceted analysis of epidemiological, clinical and experimental evidence for insulin resistance as a systemic player in the development of renal pathology. We discuss both established and potential mechanisms for this effect. Aside from being a marker for glycemic disorders, insulin resistance was shown to be an independent predictor of renal pathology, including such chronic conditions as urolithiasis, renal cysts and malignant renal neoplasms. Early detection and correction of insulin resistance is a promising approach to diagnostics, treatment and prevention of renal pathology.
При обследовании 120 мужчин с сахарным диабетом 2-го типа выявлена высокая частота ожирения (71,7%) и андрогенного дефицита (52,8-64,5% больных в зависимости от степени его компенсации), между которыми установлена достоверная связь. Уровень общего тестостерона крови представлялся критическим фактором, определявшим скорость артериального кровотока в простате. Ожирение и андрогенный дефицит являются факторам риска развития ишемической простатопатии, так как нарушения органного кровотока в предстательной железе могут возникать раньше других вариантов диабетической микроангиопатии. Ключевые слова: предстательная железа, простатическое кровообращение, ожирение, андрогенный дефицит, сахарный диабет 2-го типа. In Study at 120 Diabetes Mellitus II type men the high frequency Obesity (71,7%) and Androgen Deficiency (52,8-64,5% of the patients depending on a degree of the indemnification) and them pathogenic authentic communications were shown. The blood level of total testosterone was represented by the critical factor of Prostatic arterial Blood Circulation. Obesity and Androgen Deficiency are seem as independent risk factors to development of ischemic prostatopathy, such as Prostatic blood circulation Disorders can develop earlier than other variants of the diabetic microangiophaty.
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