Impact of Metabolic Syndrome on the Short-Term Outcomes of Colorectal Cancer Surgery

Lohsiriwat, Varut; Pongsanguansuk, Watchara; Lertakyamanee, Narong; Lohsiriwat, Darin

doi:10.1007/dcr.0b013e3181bdbc32

Cited by 41 publications

(29 citation statements)

References 31 publications

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“…Moreover, this deleterious influence was also proved for the outcomes of CRC surgery at 30 days, showing a higher rate of postoperative complications and a longer hospital stay in patients classified with the AHA/NHLBI definition of MS. Also in this study from 2009, high blood pressure and high triglyceride levels were as well considered important risk factors for severe complications after CRC surgery, but only the presence of the cluster of metabolic abnormalities that constitute MS was proven to be an independent variable in the multivariate analysis, and not each individual component [13].…”

Section: Introductionmentioning

confidence: 62%

“…In the same year another prospective study from Thailand peremptorily concluded that MS was an independent rick factor for postoperative complications and longer hospital stay in CRC patients submitted to surgery, with a 30 days follow-up [13]. On the other hand, in 2013, a retrospective cohort investigation concluded that MS had no influence on recurrence and overall survival of CRC patients, perhaps explained by the combined effects of elevated blood glucose and hypertension and the protective effect of dyslipidemia, has proven in the same study [20].…”

Section: Discussionmentioning

confidence: 99%

“…Secondly, MS has been correlated with a situation of impaired microvascular circulation, which may cause diminished perfusion and poor tissue healing. And finally, alterations in polymorphonuclear cells has been noticed in patients with MS, which might be caused by the low levels of Leukotriene B4, essential in these cells function, leading this way to alterations in innate immune defense [13].…”

Section: Discussionmentioning

confidence: 99%

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The influence of metabolic syndrome in the outcomes of colorectal cancer patients

Goulart

Varejão

Nogueira

et al. 2017

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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A B S T R A C TAims: Determine the influence of metabolic syndrome and its different components in the outcomes of colorectal cancer surgery at 30 days. Materials and methods: Prospective study that included all patients submitted to elective colorectal cancer surgery between August 2015 and August 2016 at Hospital de Braga. Clinical and laboratory parameters evaluated pre-operatively were: central obesity, blood pressure, fasting glucose, triglycerides levels and HDL cholesterol levels. Any complications during the first 30-days after surgery were recorded (readmission, reintervention, anastomotic dehiscence, morbimortality). Results: One hundred and thirty-four patients were included. Metabolic syndrome was diagnostic in 40.7% of patients with the ATPIII definition, 67.5% with the AHA definition and 67.0% with the IDF definition. At 30 days after colorectal cancer surgery, 73.1% patients don't have any complication, 15.7% have minor complications (grade I/II of Clavien-Dindo classification), 11.1% have major complications (grade III/IV/V of Clavien-Dindo classification) and 1.5% have died from surgical complications (grade V of Clavien-Dindo classification). The statistic analysis didn't reveal any association between MS, or it's different components, and surgical outcomes. Conclusion: This study seems to indicate that metabolic syndrome don't have any influence in surgical outcomes of colorectal cancer surgery.

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Section: Introductionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The influence of metabolic syndrome in the outcomes of colorectal cancer patients

Goulart

Varejão

Nogueira

et al. 2017

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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“…The syndrome diagnoses those people with a dysmetabolic profile, who are, therefore, more likely to develop insulin resistance and consequences of the obese state [87]. There is emerging evidence that the metabolic syndrome is an independent predictor of postoperative complications [93], including cardiac adverse events and acute kidney injury, even after controlling for BMI [94].…”

Section: Insulin Resistance and Type 2 Diabetes Mellitusmentioning

confidence: 99%

Perioperative evaluation of the obese patient

Donohoe

Feeney

Carey

et al. 2011

Journal of Clinical Anesthesia

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“…Эти обстоятельства обусловливают критически низкий уровень качества жизни и являются частой причиной отказа самих па-циентов от операции [20,33].…”

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Современные Взгляды На Хирургический Метод Лечения Местнораспространенного Колоректального Рака С Инвазией В Мочевой Пузырь

Башеев¹,

Балабан²,

Бондаренко³

et al. 2017

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В статье рассматривается современное состояние проблемы рака толстой кишки с инвазией в мочевой пузырь. Выделены два принципиально отличных метода оперативного лечения, такие как эвисцерация органов малого таза и мультивисцеральная резекция. Онкологические требования к обоим видам лечения – достижение R0 границы резекции, а также удаление опухоли единым блоком. Длительность эвисцерации органов малого таза варьирует от 3 до 8 часов, объем интраоперационной кровопотери – от 1,5 до 4,5л. Частота послеоперационных осложнений составляет от 35,0% до 69,6%. Послеоперационная летальность варьирует от 1% до 20%, местный рецидив от 14% до 67%. 5-летняя выживаемость составляет от 14% до 70%. Средняя продолжительность комбинированной резекции толстой кишки с инвазией в мочевой пузырь 180 минут, интраоперационная кровопотеря в - 500 мл. Частота послеоперационных осложнений не превышают 31,6%. Послеоперационная летальность варьирует от 1,7% до 11,3%, частота местного рецидива - 30,1% , 5-летняя выживаемость составляет от 35,5% до 73,8%. Частота обструктивных резекций при данных оперативных вмешательствах составляет от 21,5% до 76,9%. Проанализированные данные показывают необходимость разработки новых подходов к органсохраняющим операциям и улучшения качества и продолжительности жизни пациентов.

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Impact of Metabolic Syndrome on the Short-Term Outcomes of Colorectal Cancer Surgery

Abstract: Patients with metabolic syndrome had a higher rate of postoperative complication and a longer length of hospital stay than patients without metabolic syndrome.

Cited by 41 publications

References 31 publications

The influence of metabolic syndrome in the outcomes of colorectal cancer patients

The influence of metabolic syndrome in the outcomes of colorectal cancer patients

Perioperative evaluation of the obese patient

Современные Взгляды На Хирургический Метод Лечения Местнораспространенного Колоректального Рака С Инвазией В Мочевой Пузырь

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