Abstract:A B S T R A C TAims: Determine the influence of metabolic syndrome and its different components in the outcomes of colorectal cancer surgery at 30 days. Materials and methods: Prospective study that included all patients submitted to elective colorectal cancer surgery between August 2015 and August 2016 at Hospital de Braga. Clinical and laboratory parameters evaluated pre-operatively were: central obesity, blood pressure, fasting glucose, triglycerides levels and HDL cholesterol levels. Any complications duri… Show more
“…Previous studies suggested that dyslipidemia was a newly identified risk factor in the survival of several cancers such as colorectal, breast, and prostate cancers [ 15 , 16 , 18 ]. Although one study demonstrated that preoperative HDL level was a predictor of HCC recurrence after liver resections [ 22 ]; recently, there were few studies that addressed the association between lipid profiles and the outcome of liver cancer.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, abnormal lipid and lipoprotein levels were considered to be related with the incidence and development of several types of cancer[ 13 , 14 ]. Several researches showed that elevated TG level and suppressed high-density lipoprotein cholesterol (HDLc) level were related to a high risk of occurrence and death in colon, breast, lung, and prostate cancers[ 15 – 18 ]. However, the relationships between blood profile and liver cancer were contradictory due to the complex etiology.…”
BackgroundThe liver plays an important role in the metabolism of lipid and lipoprotein. Dyslipidemia has been demonstrated to be related with several cancers, but the association between serum lipid and hepatocellular carcinoma (HCC) in the absence of cirrhosis remains unclear.MethodsA total of 2528 patients with HCC at the Beijing Ditan Hospital between February 2008 and December 2017 were retrospectively included in the study. We identified 200 patients with HCC without cirrhosis by histopathology, imaging, endoscopic findings, and laboratory tests. Multivariate regression analysis was performed to determine the independent characteristics associated with HCC without cirrhosis and its prognosis.ResultsIn the logistics regression analysis, compared to patients with HCC with cirrhosis, patients with HCC without cirrhosis were more likely to have elevated triglyceride (TG) levels (OR = 2.66; 95% CI, 1.18–6.01; P = 0.019). The Kaplan-Meier analysis revealed that a lower TG level was a risk factor regardless of the presence of cirrhosis. The results of the Cox proportional hazard regression analysis showed that a decreased TG level was significantly related to a worse overall survival (HR = 0.51; 95% CI, 0.29–0.89; P = 0.017).ConclusionSerum TG level may be an independent factor to predict the prognosis of patients with HCC in the absence of cirrhosis.Electronic supplementary materialThe online version of this article (10.1186/s12944-018-0898-y) contains supplementary material, which is available to authorized users.
“…Previous studies suggested that dyslipidemia was a newly identified risk factor in the survival of several cancers such as colorectal, breast, and prostate cancers [ 15 , 16 , 18 ]. Although one study demonstrated that preoperative HDL level was a predictor of HCC recurrence after liver resections [ 22 ]; recently, there were few studies that addressed the association between lipid profiles and the outcome of liver cancer.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, abnormal lipid and lipoprotein levels were considered to be related with the incidence and development of several types of cancer[ 13 , 14 ]. Several researches showed that elevated TG level and suppressed high-density lipoprotein cholesterol (HDLc) level were related to a high risk of occurrence and death in colon, breast, lung, and prostate cancers[ 15 – 18 ]. However, the relationships between blood profile and liver cancer were contradictory due to the complex etiology.…”
BackgroundThe liver plays an important role in the metabolism of lipid and lipoprotein. Dyslipidemia has been demonstrated to be related with several cancers, but the association between serum lipid and hepatocellular carcinoma (HCC) in the absence of cirrhosis remains unclear.MethodsA total of 2528 patients with HCC at the Beijing Ditan Hospital between February 2008 and December 2017 were retrospectively included in the study. We identified 200 patients with HCC without cirrhosis by histopathology, imaging, endoscopic findings, and laboratory tests. Multivariate regression analysis was performed to determine the independent characteristics associated with HCC without cirrhosis and its prognosis.ResultsIn the logistics regression analysis, compared to patients with HCC with cirrhosis, patients with HCC without cirrhosis were more likely to have elevated triglyceride (TG) levels (OR = 2.66; 95% CI, 1.18–6.01; P = 0.019). The Kaplan-Meier analysis revealed that a lower TG level was a risk factor regardless of the presence of cirrhosis. The results of the Cox proportional hazard regression analysis showed that a decreased TG level was significantly related to a worse overall survival (HR = 0.51; 95% CI, 0.29–0.89; P = 0.017).ConclusionSerum TG level may be an independent factor to predict the prognosis of patients with HCC in the absence of cirrhosis.Electronic supplementary materialThe online version of this article (10.1186/s12944-018-0898-y) contains supplementary material, which is available to authorized users.
“…However, recent studies reveal a new relationship between blood lipids and the risk of the most common cancer entities. For example, low levels of serum lipids is positively associated with cancer and its mortality [ 13 , 14 , 17 ]. High level of TC or HDL is associated with a reduction of cancer mortality [ 18 ].…”
BackgroundColon cancer is a malignancy of the large intestine with high mortality and economic burden. Recent studies reveal a new relationship between blood lipids and the risk of cancer. The presents study aims to investigate the combination of serum lipids with cancer antigens as a novel diagnostic marker for colon cancer.MethodsTwo hundred of colon cancer patients or healthy subjects were recruited. Serum lipids and cancer antigens such as total cholesterol (TC), high-density lipoprotein (HDL), carcinoembryonic antigen (CEA) and carbohydrate antigen 19–9 (CA19–9) were measured.ResultsThere were significantly lower level of serum TC or HDL, and significantly higher level of serum CEA or CA19–9 in patients than in healthy subjects. Serum TC or HDL in patients with advanced colon cancer was significantly lower than the ones with early stage disease. The level of serum TC or HDL in patients after surgical removal of colon cancer was significantly higher compared to the ones before surgery, but serum CEA or CA19–9 after surgery was significantly reduced in comparison with the ones before surgery. Combined TC, HDL, CEA and CA19–9 as a diagnostic marker for colon cancer had the highest positive predictive rate in comparison with individual, two or three of the parameters.ConclusionsThe combination of serum TC, HDL, CEA and CA19–9 can be used as an effective marker for colon cancer, and offers a novel strategy for clinical diagnosis and monitoring the disease.
“…Se trata de la presencia de un conjunto de factores de riesgo presentes en un individuo, que actúan como factores independientes (1,2). Se caracteriza por la aparición, en forma simultánea o secuencial, de diversas alteraciones metabólicas e inflamatorias a escala molecular, celular o hemodinámico asociadas con alteraciones en el metabolismo glucídico -Diabetes mellitus Tipo 2 (dm2), tolerancia alterada a la glucosa o glucemia alterada en ayunas-, resistencia a la insulina, obesidad central, dislipidemia e hipertensión (3)(4)(5). No solo es una realidad clínica entre prácticamente todos los grupos étnicos, raciales y geográficos, sino que constituye un problema de salud evidente, tanto por su alta prevalencia, como por su papel como factor de riesgo de otras enfermedades que implican una gran morbimortalidad, como son las enfermedades cardiovasculares y la diabetes mellitus, para las cuales eleva en 2 y 5 veces, respectivamente, el riesgo de padecerlas (6).…”
Introduction: Metabolic Syndrome (SM) is considered a global epidemic. The increase of its prevalence is widely extended in both industrialized and developing countries and is the outcome of a rise in the proportion of obesity and sedentary lifestyle in the population. The objective of this research was to determine the prevalence of SM and associated factors in transport drivers of Tunja in the year 2017. Materials and methods: An analytical cross-sectional study was carried out on a sample of 115 inter-municipal transportation drivers in the city of Tunja, evaluating anthropometric indexes, glycemia, triglycerides, HDL and the IPAQ international physical activity questionnaire was applied. The presence of sm evaluatio followed the ncep/atp III criteria, the prevalence ratio was found, and Fisher’s exact test and Mann-Whitney U test were used to determine the significance. Results: A prevalence of 10.4% (12/115; IC 95% 4.6-15.7) was found with significant differences between the patients with and without sm in relation with hypertension (p = 0.03), glucose levels (p = 0.0004), triglycerides (p ≤ 0.001), hdl (p = 0.00004), abdominal perimeter (p = 0.008) and body mass index (p = 0.001). Conclusion: In this population of drivers, hypertriglyceridemia was the altogether criteria among those with metabolic syndrome as well as an observed trend towards overweight and obesity, which determines the importance of generating information, education and communication programs aimed at these populations to promote healthy eating and physical activity.
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