Effect of serum triglyceride level on the prognosis of patients with hepatocellular carcinoma in the absence of cirrhosis

Liu, Xiaoli; Li, Mengge; Wang, Xinhui; Dang, Zhibo; Jiang, Yuyong; Yang, Zhiyun

doi:10.1186/s12944-018-0898-y

Cited by 12 publications

(15 citation statements)

References 37 publications

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“…Consequently, there is also a discrepancy in literature reports, depending on HCC-comorbidities and associated risk factors. Increased levels of serum triglycerides were reported in HCC patients without cirrhosis [ 51 ], and another report found decreased levels of triglycerides and cholesterol to be associated with progression in hepatic pathological conditions [ 52 ]. Our finding of downregulation of lipid species in HCC patients in both blood and liver might be explained by disruption of lipid homeostasis that balance lipoprotein synthesis along with consumption of lipids by the rapidly proliferating HCC tumor cells [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

Remodeling Lipids in the Transition from Chronic Liver Disease to Hepatocellular Carcinoma

Ismail

Elfert

Helal

et al. 2020

Cancers

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Hepatocellular carcinoma (HCC) is a worldwide health problem. HCC patients show a 50% mortality within two years of diagnosis. To better understand the molecular pathogenesis at the level of lipid metabolism, untargeted UPLC MS—QTOF lipidomics data were acquired from resected human HCC tissues and their paired nontumor hepatic tissues (n = 46). Blood samples of the same HCC subjects (n = 23) were compared to chronic liver disease (CLD) (n = 15) and healthy control (n = 15) blood samples. The participants were recruited from the National Liver Institute in Egypt. The lipidomics data yielded 604 identified lipids that were divided into six super classes. Five-hundred and twenty-four blood lipids were found as significantly differentiated (p < 0.05 and qFDR p < 0.1) between the three study groups. In the blood of CLD patients compared to healthy control subjects, almost all lipid classes were significantly upregulated. In CLD patients, triacylglycerides were found as the most significantly upregulated lipid class at qFDR p = 1.3 × 10−56, followed by phosphatidylcholines at qFDR p = 3.3 × 10−51 and plasmalogens at qFDR p = 1.8 × 10-46. In contrast, almost all blood lipids were significantly downregulated in HCC patients compared to CLD patients, and in HCC tissues compared to nontumor hepatic tissues. Ceramides were found as the most significant lipid class (qFDR p = 1 × 10−14) followed by phosphatidylglycerols (qFDR p = 3 × 10−9), phosphatidylcholines and plasmalogens. Despite these major differences, there were also common trends in the transitions between healthy controls, CLD and HCC patients. In blood, several mostly saturated triacylglycerides showed a continued increase in the trajectory towards HCC, accompanied by reduced levels of saturated free fatty acids and saturated lysophospatidylcholines. In contrast, the largest overlaps of lipid alterations that were found in both HCC tissue and blood comparisons were decreased levels of phosphatidylglycerols and sphingolipids. This study highlights the specific impact of HCC tumors on the circulating lipids. Such data may be used to target lipid metabolism for prevention, early detection and treatment of HCC in the background of viral-related CLD etiology.

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Section: Discussionmentioning

confidence: 99%

Remodeling Lipids in the Transition from Chronic Liver Disease to Hepatocellular Carcinoma

Ismail

Elfert

Helal

et al. 2020

Cancers

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“… 147 , 257 Furthermore, diminished levels of circulating TG in patients with HCC are associated with worse overall survival. 258 However, due to the unspecific nature of these changes, they remain a generic biomarker of liver dysfunction. On the other hand, the changes in specific TG species may be more useful.…”

Section: Diagnostic Potential Of Circulating Lipidsmentioning

confidence: 99%

Lipid alterations in chronic liver disease and liver cancer

2022

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“…However, the association between TG and the survival of tumor patients is contradictory. Some studies observed that high level TG can improve the survival of cancer patients [32][33] . On the contrary, other studies [30][31][32][33][34] has shown that high TG can lead to poor prognosis in cancer patients.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies observed that high level TG can improve the survival of cancer patients [32][33] . On the contrary, other studies [30][31][32][33][34] has shown that high TG can lead to poor prognosis in cancer patients. In our study, TG≥1.7 mmol/L(HR 0.77, 95%CI 0.69-0.86) were protective factor of survival.…”

Section: Discussionmentioning

confidence: 99%

Development and Validation of a New Clinical Prognosis Prediction Model for Metabolism in Cancer Patients

Tang

Yang

Sun

et al. 2021

Preprint

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Background: Metabolic reprogramming has emerged as an important feature of cancer, and the metabolism-related indexes are closely related to prognosis. Therefore, we develop and verify a large sample clinical prediction model to predict the prognosis in patients with solid tumors.Methods: This retrospective analysis was conducted on a primary cohort of 5006 patients with solid tumor from INSCOC database. A total of 1720 cancer patients treated at the Fujian Cancer Hospital was used to form the validation cohort. A multivariate Cox regression analysis was performed to test the independent significance of different factors and then establish the model. The prediction model was simplified into a nomogram to predict the 1-, 3-and 5-year OS rates. To determine the discriminatory and predictive accuracy capacity of the model, the C-index and calibration curve were evaluated.Results: Multivariate analysis indicated that age, smoking history, tumor stage, tumor metastasis, PGSGA score, FBG, NLR, ALB, TG, and HDL-C were independent factors. Moreover, the nomogram combining the score and clinical parameters can predict patient survival accurately.Conclusions: Clinical indicators based on metabolism reprogramming coould well fit and predict the prognosis of cancer patients, and could provide assistance for the individual treatment of tumor patients in the clinic.

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Effect of serum triglyceride level on the prognosis of patients with hepatocellular carcinoma in the absence of cirrhosis

Cited by 12 publications

References 37 publications

Remodeling Lipids in the Transition from Chronic Liver Disease to Hepatocellular Carcinoma

Remodeling Lipids in the Transition from Chronic Liver Disease to Hepatocellular Carcinoma

Lipid alterations in chronic liver disease and liver cancer

Development and Validation of a New Clinical Prognosis Prediction Model for Metabolism in Cancer Patients

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