2018
DOI: 10.15537/smj.2018.8.22837
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## Abstract:Objectives:To evaluate cyclooxygenase-2 (COX-2) over-expression in colorectal cancer (CRC) and its role in carcinogenesis and prognosis.Methods:It was a retrospective study. Archival samples were obtained from Pathology Department at King Fahad Hospital, Madinah, Saudi Arabia, over 11 years’ period (January 2006 to December 2017). Samples were analyzed using immunohistochemistry for COX-2 and Ki67 over-expression in 324 CRC patients, 40 cases of colorectal adenomas and 20 cases of normal colonic mucosa.Results… Show more

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##### Cited by 7 publications
(9 citation statements)
##### References 29 publications
(9 reference statements)
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“…The inter-assessor agreement rate between the two pathologists was 95.6%. As for the classification of cases into low or high expression group, we referred to the study reported by Albasri AM [19]. The extent of staining was scored as follows: 0 (no staining), 1 (1–10% positive staining), 2 (10–50% positive staining), 3 (50–70% positive staining) and 4 (70–100% positive staining).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The inter-assessor agreement rate between the two pathologists was 95.6%. As for the classification of cases into low or high expression group, we referred to the study reported by Albasri AM [19]. The extent of staining was scored as follows: 0 (no staining), 1 (1–10% positive staining), 2 (10–50% positive staining), 3 (50–70% positive staining) and 4 (70–100% positive staining).…”
Section: Methodsmentioning
confidence: 99%
“…Cyclooxygenase (COX) is a rate-limiting enzyme in the prostaglandin metabolism including COX-1 and COX-2. COX-2 is extensively studied which is up-regulated in response to growth factors, cytokines and tumor-promoting factors [19]. COX-2 over-expression is also associated with poor prognosis of CRC and may be used as an indicator for the diagnosis of CRC [20].…”
Section: Introductionmentioning
confidence: 99%
“…Hence, for the purposes of interpretation of this unusual cytoplasmic expression, we considered tumor cells to be positive for p63 when a distinct cytoplasmic yellow to brown staining was identified. This distinct immunostaining pattern was independently reviewed by 2 pathologists and an average score was taken according to the method described by Albasri et al15 The p63 expression level was calculated by combining an estimate of the percentage of immunoreactive cells (a quantitative score) with an estimate of the staining intensity (a staining intensity score). The quantitative percentage score was assigned as follows: score 0 was assigned for negative or no staining, score 1 was given when 1% - 10% of cells showed positive staining, score 2 was assigned when 11% - 50% of cells showed positive staining, score 3 was given when 51% - 70% cells were positively stained, and score 4 was assigned when 71% - 100% of positively stained cells were observed.…”
Section: Methodsmentioning
confidence: 99%
“…The final expression score was stated as follows: ‘-’ for a score of 0, ‘+’ for scores 1–3, ‘++’ for scores 4 to 6 and ‘+++’ for scores >6. For statistical analysis, we combined the cases that scored ‘-’ and ‘+’ as low scores and compared them to the cases that scored ‘++’ and ‘+++’ as high scores 12,15…”
Section: Methodsmentioning
confidence: 99%
“…Activity-dependent neuroprotector homeobox (ADNP) correlates with CRC cell migration, invasion, and proliferation, and the prognosis of CRC [15]. Cyclooxygenase-2 (COX-2) is correlated with shorter survival and is an independent prognostic indicators of CRC [16]. These studies show that single gene expression may have the potential value for predicting prognosis of patients with CRC.…”
Section: Introductionmentioning
confidence: 94%