Impact of aerobic exercise versus resisted exercise on endothelial activation markers and inflammatory cytokines among elderly

El-Kader, Shehab M Abd; Al-Shreef, Fadwa M; Al-Jiffri, Osama H

doi:10.4314/ahs.v19i4.9

Cited by 21 publications

(13 citation statements)

References 39 publications

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“…At the same time, there is a reduction in post-exercise pressure that lasts up to 24 hours [ 98 ]. In a study conducted on hypertensive rats, it appears to have induced improvements in endothelial function mediated by an increase in NO, together with a reduction in systemic inflammation [ 101 ], even though these results are considered to be of lesser extent than endurance training [ 102 ].…”

Section: Cardiac Rehabilitation After Covid-19: Position Statementmentioning

confidence: 99%

Exercise Training and Cardiac Rehabilitation in COVID-19 Patients with Cardiovascular Complications: State of Art

Calabrese

Garofano

Palumbo

et al. 2021

Life

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Recent scientific literature has investigated the cardiovascular implications of COVID-19. The mechanisms of cardiovascular damage seem to involve the protein angiotensin-converting enzyme 2 (ACE2), to which severe acute respiratory syndrome (SARS) coronavirus-2 (CoV-2) binds to penetrate cells and other mechanisms, most of which are still under study. Cardiovascular sequelae of COVID-19 include heart failure, cardiomyopathy, acute coronary syndrome, arrhythmias, and venous thromboembolism. This article aims to collect scientific evidence by exploiting PubMed, Scopus, and Pedro databases to highlight the cardiovascular complications of COVID-19 and to define the physiotherapy treatment recommended for these patients. Exercise training (ET), an important part of cardiac rehabilitation, is a powerful tool in physiotherapy, capable of inducing significant changes in the cardiovascular system and functional in the recovery of endothelial dysfunction and for the containment of thromboembolic complications. In conclusion, due to the wide variety of possible exercise programs that can be obtained by combining intensity, duration, and speed in various ways, and by adjusting the program based on continuous patient monitoring, exercise training is well suited to the treatment of post-COVID patients with an impaired cardiovascular system of various degrees.

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Section: Cardiac Rehabilitation After Covid-19: Position Statementmentioning

confidence: 99%

Exercise Training and Cardiac Rehabilitation in COVID-19 Patients with Cardiovascular Complications: State of Art

Calabrese

Garofano

Palumbo

et al. 2021

Life

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“…The functional capacity of lower limb and knee joint could be evaluated by using Western Ontario and McMaster Universities Osteoarthritis (WOMAC). The WOMAC is a self-administered reliable and valid questionnaire for patients with hip and knee OA and used for assessment of pain, stiffness joints, and physical activity of patients with hip and knee OA [28,29]. The total score range of 0-96 and increased scores indicate a higher level of disability and lower level of quality of life.…”

Section: Womac Questionnairementioning

confidence: 99%

Effects of photobiomodulation and a physical exercise program on the expression of inflammatory and cartilage degradation biomarkers and functional capacity in women with knee osteoarthritis: a randomized blinded study

et al. 2021

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Background The knee osteoarthritis (OA) is a joint disease characterized by degradation of articular cartilage that leads to chronic inflammation. Exercise programs and photobiomodulation (PBM) are capable of modulating the inflammatory process of minimizing functional disability related to knee OA. However, their association on the concentration of biomarkers related to OA development has not been studied yet. The aim of the present study is to investigate the effects of PBM (via cluster) with a physical exercise program in functional capacity, serum inflammatory and cartilage degradation biomarkers in patients with knee OA. Methods Forty-two patients were randomly allocated in 3 groups: ESP: exercise + sham PBM; EAP: exercise + PBM and CG: control group. Six patients were excluded before finished the experimental period. The analyzed outcomes in baseline and 8-week were: the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) and the evaluation of serum biomarkers concentration (IL-1β, IL-6, IL-8, IL-10 e TNF-α, and CTX-II). Results An increase in the functional capacity was observed in the WOMAC total score for both treated groups (p < 0.001) and ESP presents a lower value compared to CG (p < 0.05) the 8-week post-treatment. In addition, there was a significant increase in IL-10 concentration of EAP (p < 0.05) and higher value compared to CG (p < 0.001) the 8-week post-treatment. Moreover, an increase in IL-1β concentration was observed for CG (p < 0.05). No other difference was observed comparing the other groups. Conclusion Our data suggest that the physical exercise therapy could be a strategy for increasing functional capacity and in association with PBM for increasing IL-10 levels in OA knee individuals. Trial registration: ReBEC (RBR-7t6nzr).

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“…Molecular markers modulated by IGF and VEGF, such as stromal cell derived factor 1 (SDF1) or intercellular adhesion molecule 1 (ICAM-1) were suggested to be involved in the promotion of angiogenesis in the brain after exercise based on animal studies ( Stimpson et al, 2018 ). Significantly decreased levels of ICAM-1 related to physical activity were found in patients with cardiovascular risk factors ( Palmefors et al, 2014 ) but evidence in healthy samples is still inconclusive with some ( Abd El-Kader et al, 2019 ) showing significant and others ( Mohammadi et al, 2018 ) non-significant changes in post-test vs. pre-test comparisons. In healthy young men, SDF1 levels increased in response to acute exercise with an increase of endothelial cells in a 24 h follow-up ( Chang et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Molecular and Brain Volume Changes Following Aerobic Exercise, Cognitive and Combined Training in Physically Inactive Healthy Late-Middle-Aged Adults: The Projecte Moviment Randomized Controlled Trial

Castells-Sánchez

Roig-Coll

Dacosta-Aguayo

et al. 2022

Front. Hum. Neurosci.

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Behavioral interventions have shown promising neuroprotective effects, but the cascade of molecular, brain and behavioral changes involved in these benefits remains poorly understood. Projecte Moviment is a 12-week (5 days per week—45 min per day) multi-domain, single-blind, proof-of-concept randomized controlled trial examining the cognitive effect and underlying mechanisms of an aerobic exercise (AE), computerized cognitive training (CCT) and a combined (COMB) groups compared to a waitlist control group. Adherence was > 80% for 82/109 participants recruited (62% female; age = 58.38 ± 5.47). In this study we report intervention-related changes in plasma biomarkers (BDNF, TNF-α, HGF, ICAM-1, SDF1-α) and structural-MRI (brain volume) and how they related to changes in physical activity and individual variables (age and sex) and their potential role as mediators in the cognitive changes. Our results show that although there were no significant changes in molecular biomarker concentrations in any intervention group, changes in ICAM-1 and SDF1-α were negatively associated with changes in physical activity outcomes in AE and COMB groups. Brain volume changes were found in the CCT showing a significant increase in precuneus volume. Sex moderated the brain volume change in the AE and COMB groups, suggesting that men may benefit more than women. Changes in molecular biomarkers and brain volumes did not significantly mediate the cognitive-related benefits found previously for any group. This study shows crucial initial molecular and brain volume changes related to lifestyle interventions at early stages and highlights the value of examining activity parameters, individual difference characteristics and using a multi-level analysis approach to address these questions.

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Impact of aerobic exercise versus resisted exercise on endothelial activation markers and inflammatory cytokines among elderly

Cited by 21 publications

References 39 publications

Exercise Training and Cardiac Rehabilitation in COVID-19 Patients with Cardiovascular Complications: State of Art

Exercise Training and Cardiac Rehabilitation in COVID-19 Patients with Cardiovascular Complications: State of Art

Effects of photobiomodulation and a physical exercise program on the expression of inflammatory and cartilage degradation biomarkers and functional capacity in women with knee osteoarthritis: a randomized blinded study

Molecular and Brain Volume Changes Following Aerobic Exercise, Cognitive and Combined Training in Physically Inactive Healthy Late-Middle-Aged Adults: The Projecte Moviment Randomized Controlled Trial

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