“…For instance, several studies have shown the beneficial effect of using photobiomodulation, with low- or high-level laser therapies in in vivo models or in patients with OA [ 10 , 11 , 12 ]. The effects of these therapies included reduction of pain, improvement in cartilage function and thickness [ 13 , 14 , 15 ], stimulation of angiogenesis [ 16 ], improvement in the anti-inflammatory [ 17 , 18 , 19 ], and antioxidant [ 14 ] responses. However, in many cases, these treatments alone are not enough to restore cartilage, and surgical interventions become necessary.…”