Immunotoxicity and hepatic function evaluation in Nile tilapia (Oreochromis niloticus) exposed to diazinon

Girón-Pérez, Manuel Iván; Santerre, Anne; Gonzalez-Jaime, Fabiola; Casas‐Solís, Josefina; Hernández-Coronado, Marcela; Peregrina-Sandoval, Jorge; Takemura, Akiro; Zaitseva, Galina

doi:10.1016/j.fsi.2007.02.004

Cited by 84 publications

(46 citation statements)

References 32 publications

(28 reference statements)

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“…The measurements of the activity of ALT, AST, ALP, LDH and GGT enzymes are used routinely as an indicator of hepatic dysfunction and damage [30,31]. These enzymes are principally localized in the cytoplasm and they secreted into the blood after hepatocellular injury, thereby increasing their levels in the serum [31].…”

Section: Discussionmentioning

confidence: 99%

Strain-Related Differences on Response of Liver and Kidney Antioxidant Defense System in Two Rat Strains Following Diazinon Exposure

Salehi

Jafari

Asgari

et al. 2016

Zahedan J Res Med Sci

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Background: Diazinon (DZN) is one of the most organophosphates that widely used in agriculture and ectoparasiticide formulations. Its extensive use as an effective pesticide was associated with the environmental deleterious effects on biological systems. Objectives: The aim of this study was to investigate the potency of DZN to affect serum biochemical parameters and the antioxidant defense system in the liver and kidney of two rat strains. Materials and Methods:In this experimental study, 30 female Wistar and 30 female Norway rats were randomly divided into control and DZN groups. DZN group was divided into four subgroups: 25, 50, 100 and 200 mg/kg of DZN administered groups by i.p. injection. The parameters were evaluated after 24 hours. Results: At higher doses of DZN, superoxide dismutase, catalase, glutathione S-transferase and lactate dehydrogenase activities and glutathione (GSH) and malondialdehyde levels in liver and kidney of Wistar rats were higher than Norway rats. At these concentrations, DZN increased some serum biochemical indices such as liver enzymes activities and levels of urea, uric acid and creatinine in Wistar rat. Conclusions: DZN at higher doses alters the oxidant-antioxidant balance in liver and kidney of both rat strains and induces oxidative stress, which is associated with a depletion of GSH and increased lipid peroxidation. However, Wistar rats are found to be more sensitive to the toxicity of DZN compared to Norway rats. In addition, the effect of DZN on liver antioxidant system was more than kidney.

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Section: Discussionmentioning

confidence: 99%

Strain-Related Differences on Response of Liver and Kidney Antioxidant Defense System in Two Rat Strains Following Diazinon Exposure

Salehi

Jafari

Asgari

et al. 2016

Zahedan J Res Med Sci

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“…Increase in the plasma activities of AST and ALT has also been reported in O. mykiss and Channa punctatus, exposed to diazinon and monocrotophos respectively (Banaee et al 2011;Agrahari et al 2006). Albumin and globulin make up most of the total protein part of the body and their tests are used to monitor disorders of the immune system, renal and hepatic dysfunctions (Giron-Pirez et al 2007). The decrease in total protein, albumin and globulin levels in diazinon exposed C. mrigala may be attributed to malnutrition and destruction of hepatocytes caused by diazinon toxicity.…”

Section: Discussionmentioning

confidence: 99%

Sub-lethal Effects of Diazinon on Hematological Indices and Blood Biochemical Parameters in Indian Carp, Cirrhinus mrigala (Hamilton)

Haider

Rauf²

2014

Braz. arch. biol. technol.

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“…Since hematological parameters reflect the healthy condition of a fish, they are widely used as an indicator of disease or stress caused by aquatic pollutants. Although physiological and biochemical changes induced by different organophosphate pesticides have been investigated in several fish species (malathion in Cyprinion watsoni (4), cypermethrin Heteropneustes fossilis (5), dichlorvos in Clarias batrachus (6), and diazinon in Oreochromis niloticus (7), Silurus glanis (8), and Cyprinus carpio (9)), there is a paucity of data regarding the effects of diazinon on the hematological parameters of Indian carp (Cirrhinus mrigala). As diazinon is commonly used in agricultural fields and C. mrigala is an important fresh water fish of Pakistan, the present study was carried out to find out the acute toxicity of diazinon and its effects on some hematological parameters in C. mrigala.…”

Section: Introductionmentioning

confidence: 99%

Acute toxicity of diazinon and its effects on hematological parameters in the Indian carp, Cirrhinus mrigala (Hamilton)

Rauf¹,

Arain²

2013

Turk J Vet Anim Sci

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Immunotoxicity and hepatic function evaluation in Nile tilapia (Oreochromis niloticus) exposed to diazinon

Cited by 84 publications

References 32 publications

Strain-Related Differences on Response of Liver and Kidney Antioxidant Defense System in Two Rat Strains Following Diazinon Exposure

Strain-Related Differences on Response of Liver and Kidney Antioxidant Defense System in Two Rat Strains Following Diazinon Exposure

Sub-lethal Effects of Diazinon on Hematological Indices and Blood Biochemical Parameters in Indian Carp, Cirrhinus mrigala (Hamilton)

Acute toxicity of diazinon and its effects on hematological parameters in the Indian carp, Cirrhinus mrigala (Hamilton)

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