Immunomodulatory Effects of Ethanol Extract of Curcuma Mangga Rhizomes in Mice

Yuandani, Yuandani; Suwarso, Edy

doi:10.22159/ajpcr.2017.v10i9.18398

Cited by 10 publications

(19 citation statements)

References 20 publications

(21 reference statements)

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“…consist of a monoterpen hydrocarbon class, consisting of 4 main components identified as mirsen (78.6%), β-osimen (5.1%), β-pinen (3.7%), and α-pinen( 2.9%) [3]. Pharmacological studies on C. mangga revealed that this plant has immumodulatory activity and did not cause short term toxicity [4][5]. Curcumin is able to prevent kidney damage in paracetamol-induced rats [6].…”

Section: Introductionmentioning

confidence: 99%

Nephroprotective Activity of Ethanol Extract of Curcuma Mangga Val. In Paracetamol-Induced Male Mice

Rosita

Yuandani

Marianne

2018

Asian J Pharm Clin Res

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Objective: This study aimed to evaluate nephroprotective activity of Curcuma mangga in paracetamol-induced male mice.Methods: Male mice were divided into several groups including normal control, negative, positive, and treatment groups. Treatment groups were orally administered with C. mangga extract at doses of 100, 200, and 400 mg/kg bw for 7 days. On day 7after 1 h of treatment, the mice were induced with paracetamol 1.05 g/kg bw. Serum creatinine level measurement and histopathotlogy study were performed at the end of experiment.Results: C. mangga extract was able to inhibit the increase of creatinine level and showed a significantly different from negative control (p<0.05) and did not different significantly from positive control (p>0.05). The result was supported by histopathology examination which did not show any cell damage. The nephroprotective effect of C. mangga was in a dose-dependent manner. C. mangga extract at dose of 400 mg/kg bw depicted the strongest nephroprotective effect.Conclusion: C. mangga extract was able to protect mice kidney induced by paracetamol.

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Section: Introductionmentioning

confidence: 99%

Nephroprotective Activity of Ethanol Extract of Curcuma Mangga Val. In Paracetamol-Induced Male Mice

Rosita

Yuandani

Marianne

2018

Asian J Pharm Clin Res

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“…This plant has long been used in traditional medicine for the treatment of various diseases such as fever, stomach disorders and cancer [6]. Previous study has showed the immunomodulatory properties of C. mangga [7]. The anticancer, anti-inflammatory, antifungal and nitric oxide inhibitory activities of C. mangga have also been reported [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Activity of Curcuma mangga Extract on Paracetamol-Induced Male Mice

Yuandani

Mardaliza²,

Marianne³

2018

idjpcr

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This study was carried out to investigate the protective effect of ethanol extract of Curcuma mangga rhizomes on paracetamol-induced hepatotoxicity. High dose of paracetamol (1.35g/kg bw) was used to induce hepatic necrosis of mice liver. The male mice received ethanol extract of C. mangga rhizomes (100, 200 and 400 mg/kg BW) for 7 days. The hepatoprotective actvity of extract was compared to normal, positive (curcuma) and negative control. The liver function was evaluated by measuring the biochemistry parameters which include alanine aminotransferase (ALT) and aspartate aminotransferase (AST). In addition, histophatological study on hepatic tissue section was also carried out. The C. mangga extract displayed hepatoprotective effect except at dose of 100 mg/kg bw. The increasing of serum levels of AST and ALT were inhibited after treatment with ethanol extract at doses of 200 and 400 mg/kb bw which was comparable with normal and curcuma as postive control (p>0.05). In addition, histological assessment of hepatic tissue demonstrated no liver damage, specially at dose of 400 mg/kb BW. The result indicate that ethanol extract of C. mangga rhizomes has hepatoprotective effect, especially at doses of 200 and 400 mg/kg bw . Keywords: C. mangga, rhizomes, biochemistry parameters, histopathology

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“…Our previous study has displayed the immunomodulatory activities of C. mangga on phagocytosis, as well as delayed type hypersensitivity reaction and titer antibody by in vivo study in bovine-red blood cells challenged-rats ( 11 12 ). C. mangga has also been evaluated for its toxic effect which revealed that its LD50 was more than 5000 mg/kg BW, indicating that it was nontoxic ( 13 ). The in vitro nitric oxide inhibitory activity of methanol extract of C. mangga has also been reported ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory effects of standardized extract of Curcuma mangga val. on cytokines, antibody and delayed-type hypersensitivity response in Wistar rats

et al. 2021

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Background and purpose: Recently, we have highlighted the immunomodulatory activity of Curcuma mangga Val. on phagocytosis ability. The current study was conducted to determine the immunomodulatory effects of the standardized extract of C. mangga rhizomes by in vitro and in vivo studies. Experimental approach: The C. mangga extract was standardized according to a guideline for herbal preparation. The extract was investigated for its immunomodulatory effects on gene expression of cytokines, cytokines and antibody production as well as delayed-type hypersensitivity (DTH) response. The gene expression of cytokines on lipopolysaccharide-induced-RAW 264.7 cells was analysed by reverse transcription-polymerase chain reaction (RT-PCR) method. The effect of the extract on DTH response was investigated by the paw edema method, meanwhile the effects of the extract on antibody and cytokine production from normal and cyclophosphamide-induced Salmonella typhimurium infected rats were determined using an enzyme-linked immunosorbent assay (ELISA). Findings/Results: The extract of C. mangga demonstrated an inhibitory effect on gene expression of interleukin-1β (IL-1β), tumor necrosis factor-α, and IL-6 as compared to lipopolysaccharide-induced cells. The extract also depicted inhibitory activity on IL-4 production as compared to the negative control. Whereas, the DTH response and production of immunoglobulin G from both groups after treatment with C. mangga extract were higher than those of negative control ( P < 0.05). Conclusion and implications: The results indicated that the C. mangga extract has immunomodulatory effects, emphasizing its potential to be developed as immunotherapeutic agent.

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Immunomodulatory Effects of Ethanol Extract of Curcuma Mangga Rhizomes in Mice

Cited by 10 publications

References 20 publications

Nephroprotective Activity of Ethanol Extract of Curcuma Mangga Val. In Paracetamol-Induced Male Mice

Nephroprotective Activity of Ethanol Extract of Curcuma Mangga Val. In Paracetamol-Induced Male Mice

Hepatoprotective Activity of Curcuma mangga Extract on Paracetamol-Induced Male Mice

Immunomodulatory effects of standardized extract of Curcuma mangga val. on cytokines, antibody and delayed-type hypersensitivity response in Wistar rats

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