Immunohistologic analysis of the cholesteatoma matrix in children

Mayot, D.; Béné, Marie C.; Fauré, G; Wayoff, M; Perrin, C

doi:10.1016/0165-5876(91)90031-6

Cited by 7 publications

(2 citation statements)

References 9 publications

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“…In a previous study 12 , our group found several indications that the degree of histological inflammation would be strongly correlated with the perimatrix thickness of cholesteatomas. According to Mayot et al 27 , in the case of chronic otitis media, the immune system defenses coming from the middle ear mucus would be recruited and would contribute to the pathogenia of the cholesteatoma. Therefore, perimatrix inflammation could contribute to the aberrant behavior of cholesteatoma 28 .…”

Section: Discussionmentioning

confidence: 99%

Hystology findings' correlation between the ossicular chain in the transoperative and cholesteatomas

Dornelles

Rosito²,

Meurer³

et al. 2007

Brazilian Journal of Otorhinolaryngology

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Section: Discussionmentioning

confidence: 99%

Hystology findings' correlation between the ossicular chain in the transoperative and cholesteatomas

Dornelles

Rosito²,

Meurer³

et al. 2007

Brazilian Journal of Otorhinolaryngology

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“…Therefore, increased CD-31 immunopositivity and the number of microvessels were accepted to be biological markers of chelesteatoma activity. Dornelles et al compared 60 pediatric and 60 adult patients in their study and they found the density of CD-31 as 7 (4)(5)(6)(7)(8)(9)(10)(11) in the pediatric patient group and as 4 (0-10) in the adult patient group (5). They evaluated this difference to be statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Subepithelial Angiogenesis in Acquired Cholesteatoma between Pediatric and Adult Patients

Aslıer

Erdağ

Sarıoğlu

et al. 2015

Turk Arch Otorhinolaryngol

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Objective: The aim of this study was to compare subepithelial angiogenesis developing within the perimatrix of the cholesteatoma between pediatric and adult patients. Methods:Sixty-one patients who underwent mastoidectomy for the first intent because of chronic otitis media with cholesteatoma between 1993 and 2013 and from whom appropriate tissue specimens were taken were included in the study. The patients were classified in the pediatric patient group if they were under the age of 18 years and the adult patient group if they were 18 years and older. Immunohistochemical staining for CD-31 was performed on new sections taken during surgery and sections prepared from archived tissues in paraffin blocks. Results were compared between the groups.Results: A total of 61 patients, of whom 25 were pediatric and 36 were adult patients, were included in the study. The mean CD-31 immunopositive microvessel rates were 8.8 (3-15) and 6.61 (2-14) for the pediatric and adult patient groups, respectively. The difference between the groups was statistically significant (p=0.037). Correlation analysis showed a statistically significant negative correlation between the CD-31 immunopositive microvessel rates and age (p=0.036). Conclusion:Subepithelial angiogenesis developing within the perimatrix of the cholesteatoma of the pediatric patients was more expressed than that of the adult patients. Keywords

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