Immunohistochemical characteristics of cystic odontogenic lesions: a comparative study

Özcan, Ayhan; Yavan, İbrahim; Günhan, Ömer

doi:10.5146/tjpath.2014.01298

Cited by 9 publications

(10 citation statements)

References 34 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…e distribution patterns of syndecan-1 in the epithelia of DC, OKC, and AB in this study were consistent with the findings of other studies [37,38,40,41]. ey were, however, unlike those ofÖzcan et al, who reported a different distribution in the OKC, describing it as a strong membranous expression in basal and suprabasal cells only, while, as in this study, it involved the full thickness of DC lining [39].…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Maspin, Syndecan-1, and Ki-67 in the Odontogenic Keratocyst: An Immunohistochemical Analysis

Hammad

Nagrash

Safadi

2020

International Journal of Dentistry

View full text Add to dashboard Cite

The odontogenic keratocyst (OKC) is a controversial lesion that was reclassified as a tumor with the name “keratocystic odontogenic tumor” in 2005. The reclassification was revoked recently in 2017, with a conclusion on the need for further studies on the subject. In this study, the expressions of an important regulatory protein (maspin), an important integral membrane proteoglycan (syndecan-1), and a universal proliferation marker (Ki-67) in the epithelium of the OKC were investigated in comparison with the dentigerous cyst (DC) and ameloblastoma (AB). Twenty-six OKCs, eleven DCs, and ten conventional ABs were immunohistochemically stained for maspin, syndecan-1, and Ki-67. ImageJ was used to analyze the positivity of maspin and syndecan-1. The Ki-67 score was calculated as the percentage of positive nuclei in 5 high power fields. Analysis of variance (ANOVA) test and Student t-test were used as appropriate. Lower expressions of maspin were noted in OKC and DC compared to those in AB, and lower expressions of syndecan-1 were noted in OKC and AB compared to those in DC. The differences, however, did not reach statistical significance (ANOVA and t-test: P>0.05). The Ki-67 score was significantly higher in OKC than in DC (t-test: P<0.05), and not significantly different from AB (t-test: P>0.05). In conclusion, expressions of maspin and syndecan-1 are not strongly representative of differences in behavior between OKC, AB, and DC. However, the expression of Ki-67 indicates comparable proliferative activities of OKC and AB, which are higher than that of DC. Further investigation on the biologic behavior of OKC is still recommended to arrive at more specific conclusions regarding its classification.

show abstract

Section: Discussionsupporting

confidence: 92%

“…Some biologic markers have not been investigated in the OKC yet, such as mammary serine protease inhibitor (maspin). Other markers were investigated only in a few studies, such as syndecan-1 [37][38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

Maspin, Syndecan-1, and Ki-67 in the Odontogenic Keratocyst: An Immunohistochemical Analysis

Hammad

Nagrash

Safadi

2020

International Journal of Dentistry

View full text Add to dashboard Cite

show abstract

“…Of these, classical cadherins are the greatest widely studied and E-cadherin belongs to the classical cadherins mediating intercellular adhesion at the level of epithelia so maintains the structural and functional integrity of epithelial tissues (14) . E-cadherin expression is inversely correlated to the grade of differentiation in different cancers (15,16). On the other hand, E-cadherin is related to aggressive cancer in many organs as, breast cancer, ovarian carcinomas, and glioblastomas, where E-cadherin is linked to decline survival and correlates with enhanced invasiveness (17)(18)(19)(20) .…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Expression of Cortactin, E-Cadherin, and MDM2 Proteins in Solid Ameloblastoma versus Odontogenic Keratocyst (An immunohistochemical study)

et al. 2019

View full text Add to dashboard Cite

Purpose:The extent of invasion can be analyzed by the expression and production of various genes and proteins by lesional cells. However, current clinical parameters lack the potential to predict the neoplastic behavior in solid ameloblastoma (SAB) and odontogenic keratocyst (OKC). Cortactin, an F-actin binding protein, overexpression has been correlated with advanced clinic pathological stage and poor prognosis in several tumors. E-cadherin belongs to the classical cadherins which. Low E-cadherin expression correlated to aggressive, poorly differentiated, high-grade carcinomas and low patient survival. Human-murine double minute 2 (MDM2), contributes to the promotion of cell growth, survival, invasion, and therapeutic resistance, overexpression of MDM2 has been observed in various human cancers and can contribute to genomic instability, thus, further promoting tumorigenesis. The purpose of this work was to investigate the role of Cortactin, E-Cadherin, MDM2 proteins expression in SAB and OKC and correlate the expression of these markers with the aggressive behavior of these tumors. Material and method: 10 case of solid ameloblastoma with its different histologic variants and 10 cases of the keratocystic odontogenic tumor were collected as paraffin embedded blocks. An immunohistochemical investigation using, Cortactin, E-Cadherin, and MDM2 antibodieswere done for all specimens. Results: The mean area percent of immunoexpression of Cortactin was greatest in SAB while, the mean area percent of immunoexpression of E-Cadherin, MDM2 were greatest in OKC. Conculsion:According to the current study, the absence of any significant differences between AB and OKC indicate the neoplastic and aggressive nature of OKC similar to AB.

show abstract

“…In AMs and cystic lesions, the displacement of syndecan-1 from epithelium to stroma could be related to aggressiveness. [ 16 18 ]…”

Section: Resultsmentioning

confidence: 99%

Proteoglycans as potential biomarkers in odontogenic tumors

Gómez-Herrera

Molina-Frechero

Damián-Matsumura

et al. 2018

J Oral Maxillofac Pathol

View full text Add to dashboard Cite

Immunohistochemical characteristics of cystic odontogenic lesions: a comparative study

Cited by 9 publications

References 34 publications

Maspin, Syndecan-1, and Ki-67 in the Odontogenic Keratocyst: An Immunohistochemical Analysis

Maspin, Syndecan-1, and Ki-67 in the Odontogenic Keratocyst: An Immunohistochemical Analysis

Immunohistochemical Expression of Cortactin, E-Cadherin, and MDM2 Proteins in Solid Ameloblastoma versus Odontogenic Keratocyst (An immunohistochemical study)

Proteoglycans as potential biomarkers in odontogenic tumors

Contact Info

Product

Resources

About