Immunogenicity of the AIK-C measles vaccine in infants aged &lt;9 months in Vietnam

Hong, Duong Thi; Hien, Nguyen Dang; Thao, Pham Thi Phuong; Anh, Đặng Đức; Si, Hong, Hoang; Huyen, Dang Thi Thanh; Huong, Nguyen Lien; Phuong, Bui Huy; Iijima, Makiko; Ito, Takashi; Nakayama, Tetsuo

doi:10.1016/j.vaccine.2019.04.025

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…Immune responses were influenced by pre-immunization antibody levels in a clinical study using the AIK-C vaccine [30]. Low levels of measles antibody did not influence the immunogenicity of measles vaccines, but higher levels of measles antibody reduced the virus growth, resulting in poor immune responses.…”

Section: Discussionmentioning

confidence: 99%

“…Comparative clinical trials showed that the standard potency of the AIK-C strain vaccine induced a stronger serological response than the other high potency measles vaccines and was expected to be used for infants <9 months in developing countries [30,[35][36][37]. These biological characteristics are clinically beneficial for the development of an AIK-C vector-based vaccine for young infants.…”

Section: Discussionmentioning

confidence: 99%

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Chimeric Measles Virus (MV/RSV), Having Ectodomains of Respiratory Syncytial Virus (RSV) F and G Proteins Instead of Measles Envelope Proteins, Induced Protective Antibodies against RSV

et al. 2021

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In our previous study, fusion (F) or glyco (G) protein coding sequence of respiratory syncytial virus (RSV) was inserted at the P/M junction of the measles AIK-C vector (MVAIK), and the recombinant measles virus induced protective immune responses. In the present study, the ectodomains of measles fusion (F) and hemagglutinin (HA) proteins were replaced with those of RSV F and G proteins, and a chimeric MV/RSV vaccine was developed. It expressed F and G proteins of RSV and induced cytopathic effect (CPE) in epithelial cell lines (Vero, A549, and HEp-2 cells), but not in lymphoid cell lines (B95a, Jurkat, and U937 cells). A chimeric MV/RSV grew similarly to AIK-C with no virus growth at 39 °C. It induced NT antibodies against RSV in cotton rats three weeks after immunization through intramuscular route and enhanced response was observed after the second dose at eight weeks. After the RSV challenge with 106 PFU, significantly lower virus (101.4±0.1 PFU of RSV) was recovered from lung tissue in the chimeric MV/RSV vaccine group than in the MVAIK control group with 104.6 ± 0.2 PFU (p < 0.001) and no obvious inflammatory pathological finding was noted. The strategy of ectodomain replacement in the measles virus vector is expected to lead to the development of safe and effective vaccines for other enveloped viruses.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Chimeric Measles Virus (MV/RSV), Having Ectodomains of Respiratory Syncytial Virus (RSV) F and G Proteins Instead of Measles Envelope Proteins, Induced Protective Antibodies against RSV

et al. 2021

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“…Another strategy is to vaccinate children twice in infancy (Fowlkes et al, 2016;Zhanga et al, 2017;Hong et al, 2019). This regime, when used in Guinea and China, has resulted in high coverage, high antibody concentrations, excellent protection against measles, and increased survival of children by 30%.…”

Section: Introductionmentioning

confidence: 99%

“…The measles virus is also considered to be involved in the development of chronic subacute sclerosing panencephalitis (SSPE), which can develop a few years after measles (Trykhlib еt al., 2018). Measles remains one of the leading causes of death among infants worldwide, despite the availability of a safe and effective vaccine (Datta et al, 2018;Hong et al, 2019). Development of the severe course and complications of measles, particularly among pediatric patients, the lack of specific etiotropic treatment, makes the problem of knowing the features of the clinical course of measles, timely diagnosis and active prevention of this vaccine-manageable disease most urgent in the modern period.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and features of the measles course in children during the outbreak of 2018–2019 in the city of Mariupol

Koniushevska

Parkhomenko

Sharunova³

et al. 2020

Regul. Mech. Biosyst.

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In 2017, Ukraine ranked in the top three among European countries in terms of measles incidence, and ranked first in measles growth in 2018. High morbidity, mortality and development of complications make the problem of knowing features of the measles clinical course, timely diagnosis and active prevention highly relevant. The purpose of the research is to study the dynamics of the incidence and clinical features of measles in children during the outbreak of 2018–2019 in the city of Mariupol, Donetsk region. A peculiarity of the measles outbreak in 2018–2019 in Mariupol is prevalence of the disease in preschool children (60.4%), including 30.2% – those under one year of age; low vaccination rate: 52.3% of children unvaccinated; only 22.2% of children were vaccinated twice, according to the schedule. In all age groups, a moderately severe measles course prevailed (69.8%). The clinical course of measles in preschool and school age children had definitive features. Thus, Belsky–Filatov–Koplik spots were observed three times more frequently in preschool children than in schoolchildren (63.9% and 23.3%, respectively). Abdominal pain and diarrhea were only observed in children under 6 years of age (30.2%). Skin pigmentation was absent in children under one year of age and was detected in preschool and school-age children (69.8%). Skin sloughing was only observed in schoolchildren (10.4%). Severe disease course occurred in patients of all ages (29.3%), but children aged under one year and preschool children with severe disease were two times more numerous than those of the school age. Among the observed complications, the vast majority were associated with the respiratory organs: pneumonia (38.3%), subcutaneous emphysema (1.7%), bronchitis (53.2%), laryngitis (3.3%), otitis media (5%). No fatalities were observed. The city should form a commitment to immunization, restore public trust in vaccination, using all forms and means of information, and develop a program to implement the vaccination schedule into practice.

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Hair cortisol is not associated with reactogenicity after MMR-vaccination in 6-month-old infants

Malon

Jensen

Zimakoff

et al. 2023

Brain, Behavior, & Immunity - Health

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Immunogenicity of the AIK-C measles vaccine in infants aged <9 months in Vietnam

Cited by 5 publications

References 25 publications

Chimeric Measles Virus (MV/RSV), Having Ectodomains of Respiratory Syncytial Virus (RSV) F and G Proteins Instead of Measles Envelope Proteins, Induced Protective Antibodies against RSV

Chimeric Measles Virus (MV/RSV), Having Ectodomains of Respiratory Syncytial Virus (RSV) F and G Proteins Instead of Measles Envelope Proteins, Induced Protective Antibodies against RSV

Epidemiology and features of the measles course in children during the outbreak of 2018–2019 in the city of Mariupol

Hair cortisol is not associated with reactogenicity after MMR-vaccination in 6-month-old infants

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Immunogenicity of the AIK-C measles vaccine in infants aged <9 months in Vietnam

Cited by 5 publications

References 25 publications

Chimeric Measles Virus (MV/RSV), Having Ectodomains of Respiratory Syncytial Virus (RSV) F and G Proteins Instead of Measles Envelope Proteins, Induced Protective Antibodies against RSV

Chimeric Measles Virus (MV/RSV), Having Ectodomains of Respiratory Syncytial Virus (RSV) F and G Proteins Instead of Measles Envelope Proteins, Induced Protective Antibodies against RSV

Epidemiology and features of the measles course in children during the outbreak of 2018–2019 in the city of Mariupol

Hair cortisol is not associated with reactogenicity after MMR-vaccination in 6-month-old infants

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Immunogenicity of the AIK-C measles vaccine in infants aged <9 months in Vietnam