Identification and characterization of major flavonoids and caffeoylquinic acids in three Compositae plants by LC/DAD-APCI/MS

Lai, Jia-Ping; Lim, Yew Heng; Su, Jin; Shen, Han‐Ming; Ong, Choon Nam

doi:10.1016/j.jchromb.2006.10.028

Cited by 175 publications

(119 citation statements)

References 30 publications

(35 reference statements)

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“…Dicaffeoylquinic acid (6), apigenin (26), and N.I. 9 (27) were negatively correlated with antioxidant (´0.47 < r <´0.29) and tyrosinase inhibition activities (´0.34 < r <´0.22). The results indicated that there were metabolic differences between Fagaceae and Asteraceae, and these metabolic differences contributed to different bioactivities of Fagaceae and Asteraceae.…”

Section: Quinic Acid (1) 6-hydroxykaempferol-o-galloylhexoside (3) mentioning

confidence: 99%

“…Liquid chromatography-mass spectrometry (LC-MS)-based metabolite profiling is valuable for analysis of compounds over a wide range of polarity and molecular weight [26]. Beneficial secondary compounds in plants, such as flavonoids, phenolic compounds, and terpenoids have been identified [27,28], and plant bioactivities, including antioxidant activity [29], antimicrobial activity, and tyrosinase inhibition activity [30] have been reported. However, few studies have attempted to reveal the relationship between metabolite differences and bioactivity in diverse plant species.…”

Section: Introductionmentioning

confidence: 99%

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Chemotaxonomic Metabolite Profiling of 62 Indigenous Plant Species and Its Correlation with Bioactivities

Lee

et al. 2015

Molecules

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Chemotaxonomic metabolite profiling of 62 indigenous Korean plant species was performed by ultrahigh performance liquid chromatography (UHPLC)-linear trap quadrupole-ion trap (LTQ-IT) mass spectrometry/mass spectrometry (MS/MS) combined with multivariate statistical analysis. In partial least squares discriminant analysis (PLS-DA), the 62 species clustered depending on their phylogenetic family, in particular, Aceraceae, Betulaceae, and Fagaceae were distinguished from Rosaceae, Fabaceae, and Asteraceae. Quinic acid, gallic acid, quercetin, quercetin derivatives, kaempferol, and kaempferol derivatives were identified as family-specific metabolites, and were found in relatively high concentrations in Aceraceae, Betulaceae, and Fagaceae. Fagaceae and Asteraceae were selected based on results of PLS-DA and bioactivities to determine the correlation between metabolic differences among plant families and bioactivities. Quinic acid, quercetin, kaempferol, quercetin derivatives, and kaempferol derivatives were found in higher concentrations in Fagaceae than in Asteraceae, and were positively correlated with antioxidant and tyrosinase inhibition activities. These results suggest that metabolite profiling was a useful tool for finding the different metabolic states of each plant family and understanding the correlation between metabolites and bioactivities in accordance with plant family.

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Section: Quinic Acid (1) 6-hydroxykaempferol-o-galloylhexoside (3) mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemotaxonomic Metabolite Profiling of 62 Indigenous Plant Species and Its Correlation with Bioactivities

Lee

et al. 2015

Molecules

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“…These perennial flowering plants are commonly available in Asia, northeastern Europe and most species originate from East Asia 1,2 . According to the literature survey more varieties of Chrysanthemums are mainly cultivated in china such as Shen-nong Sweet Chrysanthemum, Tender Huang-ju, Chamomile Flower, Hangzhou White Chrysanthemum, Florists Chrysanthemum, etc [3][4][5] . Chrysanthemum plants belong to Asteraceae family which has low molecular components include flavonoids 6 , sesquiterpenes 7 , triterpenes 8 , and unsaturated fatty acids 9 .…”

Section: Introduction Of Chrysanthemum Sppmentioning

confidence: 99%

An Up-to-Date Review of Phytochemicals and Biological Activities in Chrysanthemum spp

Chae¹

2016

Biosci., Biotech. Res. Asia

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The Chrysanthemum is a well-known traditional Chinese medicinal herb which has been used as a drug for thousands of years. From the detailed literature survey it is determined that the dried flowers of Chrysanthemum contain organic groups such as alkanes, flavonoids, terpinoids, unsaturated fatty acids and polysaccharides which belongs to Secondary constituents in Phytochemicals classification. The knowledge and analysis of bioactive compounds present in the Chrysanthemums can be used for next generation drug development process. The developments of new drugs against diabetes and prostate cancer have become global concern. Hence the present study leads to identify the new strategies which are needed to develop multi-functional drugs against various human diseases using Chrysanthemum plant. Owing to antifungal, antibacterial and anti-inflammation activities, Chrysanthemum have much attention in the field of biomolecules research. In general Phytochemicals can be classified as primary and secondary constituents. One can understand the fascinating properties of biological compounds via phytochemical analysis which are present in the plants. Therefore, the present study gives a better understanding of phytochemical properties of Chrysanthemum and new foundations for the production of non-toxic and eco-friendly drugs of today and the future.

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“…29 It has various biological features, including anti-inflammation, 30 antioxidant activity, 31 cardiovascular protection, 32 antitumorigenesis, 33 anti-HIV, 34 and anti-aging activities. 35 It contains a wide variety of flavonoids, 36 caffeoylquinic acids, 37 chlorogenic acid, 38 phenolic acids, 39 etc, which could be used as reductants to react with silver ions and as scaffolds to direct the formation of AgNP in solution.…”

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confidence: 99%

Green synthesis of silver nanoparticles by Chrysanthemum morifolium Ramat. extract and their application in clinical ultrasound gel

He¹,

Du²,

Lv³

et al. 2013

IJN

143

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Eco-friendly green synthesis with plant extracts plays a very important role in nanotechnology, without any harmful chemicals. In this report, the synthesis of water-soluble silver nanoparticles was developed by treating silver ions with Chrysanthemum morifolium Ramat. extract at room temperature. The effect of the extract on the formation of silver nanoparticles was characterized by ultraviolet and visible absorption spectroscopy, X-ray diffraction, transmission electron microscopy, and Fourier transform infrared spectroscopy. The ultraviolet and visible absorption spectroscopy results show a strong resonance centered on the surface of silver nanoparticles (AgNP) at 430 nm. The Fourier transform infrared spectroscopy spectral study demonstrates Chrysanthemum morifolium Ramat. extract acted as the reducing and stabilizing agent during the synthesis. The X-ray diffraction analysis confirmed that the synthesized AgNP are single crystallines, corresponding with the result of transmission electron microscopy. Water-soluble AgNP, with an approximate size of 20 nm-50 nm were also observed in the transmission electron microscopy image. The bactericidal properties of the synthesized AgNP were investigated using the agar-dilution method and the growth-inhibition test. The results show the AgNP had potent bactericidal activity on Staphylococcus aureus and Escherichia coli, as well as a strong antibacterial activity against gram-negative bacteria, as compared to gram-positive bacteria with a dose-dependent effect, thus providing a clinical ultrasound gel with bactericidal property for prevention of cross infections.

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Identification and characterization of major flavonoids and caffeoylquinic acids in three Compositae plants by LC/DAD-APCI/MS

Cited by 175 publications

References 30 publications

Chemotaxonomic Metabolite Profiling of 62 Indigenous Plant Species and Its Correlation with Bioactivities

Chemotaxonomic Metabolite Profiling of 62 Indigenous Plant Species and Its Correlation with Bioactivities

An Up-to-Date Review of Phytochemicals and Biological Activities in Chrysanthemum spp

Green synthesis of silver nanoparticles by Chrysanthemum morifolium Ramat. extract and their application in clinical ultrasound gel

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