Ibuprofen and Acetaminophen: Effect on Muscle Inflammation after Eccentric Exercise

Abstract

Maximal over-the-counter doses of ibuprofen or acetaminophen, when administered therapeutically, do not affect muscle concentrations of neutrophils or macrophages 24 h after a novel bout of eccentric contractions.

Efeito do uso profilático do anti-inflamatório não-esteroide ibuprofeno sobre o desempenho em uma sessão de treino de força

“…The volunteers ingested one ibuprofen tablet (1.2 g) or a placebo tablet (microcrystalline cellulose) with the same shape, color, weight, odor and taste of the ibuprofen 15 . A single researcher was responsible for the randomization and distribution of the tablets to the participants.…”

“…The correlation between NSAI and strength training (also called resistance training) has already been approached by investigations which focused on the effects of the prophylactic 12,13 or therapeutic use 12,[14][15][16] of these pharmaceuticals in the treatment of the symptoms of muscular damage induced by eccentric exercise, especially delayed muscular pain. Moreover, the chronic effect of NSAI use on the hypertrophic response and the strength increase after a period of strength training has been studied 17,18 .…”

Pain management in sports medicine: Use and abuse of anti-inflammatory and other agents

“…The majority of these studies have failed to show any benefit of the administration of the anti-inflammatory medication with respect to induced muscle pain. 20,[39][40][41][42][43] Indeed, preliminary work in our laboratory has indicated that early administration of meloxicam prior to induced eccentric load damage results in higher concentrations of creatine kinase compared to administration of the agent 48 hours after muscle damage is induced. These findings suggest that early treatment with meloxicam might increase the extent of muscle damage induced by eccentric load exercise.…”

“…5,6,47 A review of the above studies certainly suggests that the anti-inflammatory agents and indeed both the non-selective NSAIDs and the COXIBs have a significant negative effect on musculoskeletal tissue healing and this finding remains a subject of much debate. 40,[48][49][50] This is particularly evident with respect to animal study models. Whilst animal studies are important precursors in initial evaluation of drug safety and efficacy, care should be taken in extrapolating the results in many of these laboratory based studies to the clinical setting.…”

Acetaminophen effect on reaction speed and lower limbs power

“…Often, in sports field, the contraction-induced muscle injury (muscle soreness, inflammation, and dysfunction) is treated with nonsteroidal antiinflammatory drugs and/or analgesics like acetaminophen. The majority of recent studies failedthough to demonstrate a beneficial effect of nonsteroidal anti-inflammatory drugs or analgesics in these cases, [4][5][6][7][8] and very few studies reported a reduction in muscle soreness and muscle dysfunction [9,10]. A considerable number of previous studies show that acetaminophen has no effects that could alter exercise capacity or performance and likewise exercise has no influence on the pharmacokinetics of acetaminophen.…”