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Since its first identification in Scotland, over 1000 cases of unexplained pediatric hepatitis in children have been reported worldwide, including 278 cases in the UK 1 . Here we report investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator subjects, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in liver, blood, plasma or stool from 27/28 cases. We found low levels of Adenovirus (HAdV) and Human Herpesvirus 6B (HHV-6B), in 23/31 and 16/23 respectively of the cases tested. In contrast, AAV2 was infrequently detected at low titre in blood or liver from control children with HAdV, even when profoundly immunosuppressed.AAV2, HAdV and HHV-6 phylogeny excluded emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T-cells and B-lineage cells.Proteomic comparison of liver tissue from cases and healthy controls, identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins.HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and in severe cases HHV-6B, may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children.

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The new demographic perspectives lead to the necessity to develop new solutions based on the Internet of Things (IoT) technology, which is designed for the early identification of the health issues of the elderly people and for providing support to them so as to understand the factors that limit their Quality of Life (QoL). An adaptive technology, a personalized intervention and integrated wearable IoT devices have the potential to improve the national healthcare systems, especially the least developed ones, the efficacity of the provided services and thus, the QoL and the wellbeing of the elderly. This paper presents a user-oriented approach to the development of personalised assistive solutions in the field of elderly care, by identifying the needs and preferences of the older adults and translating them into development requirements of the vINCI platform, an ecosystem capable of providing a non-intrusive and personalised monitoring of physical and health parameters. In this regard, prior to the development of vINCI platform, two questionnaires were applied to a group of 62 participants aged 65 years or older without severe impairments, who were admitted as inpatients to "Ana Aslan" National Institute of Gerontology and Geriatrics in Bucharest and 62 formal and informal caregivers, with the purpose of identifying the needs of users. The vINCI technology aims to help the elderly people live independently and provides support for the implementation of preventive measures for healthcare.

Background:Acetaminophen (also known as Tylenol or Paracetamol) is a very popular drug, that requires no prescription and is usually used as analgesic and antipyretic. A considerable number of previous studies show that acetaminophen has no effects that could alter exercise capacity or performance. Onthe other hand, there are studies sustaining that exercise performance can be improved with acetaminophen through a reduction in perceived pain, and also a reduction of the body heat produced by the muscle contraction.Purpose:The aim of our study was to check if acetaminophen influences reaction speed and power of the lower limbs muscles. Participants and method:For this study we recruited twenty-nine males, aged between 19 and 28 years old. We had two testing sessions for each participant, in the same day (the baseline evaluation, and the second evaluation at half an hour after acetaminophen ingestion).The evaluationsequence was: Body composition evaluation, acoustic-visual reaction test for one leg (left and right), Squad jump on one leg (5 jumps on each foot) and Stiffness test (7 jumps

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Osteopoikilosis (OPK) is a very rare and primarily benign autosomal dominant disorder of unknown etiology. Genetic studies showed heterozygous mutations of the LEMD3 gene. It is characterised by the occurrence of hyperostotic spots throughout the skeleton, with the most frequent localizations in the epiphyses and metaphyses of long bones, as well as in the carpal and tarsal bones. The clinical features of osteopoikilosis are poorly represented; consequently the condition is usually diagnosed incidentally on radiological examination or due to the association with other medical disorders (articular pain, fractures, joint dislocations, etc.). We report a case of osteopoikilosis in a 44 year-old man who presented with left hip joint pain and low back pain irradiated in left leg. Radiographs showed typical features of osteopoikilosis. Necessary investigations were done to exclude osteoblastic metastasis. The patient was treated with drugs and physiotherapy with significant improvement of the symptoms.