Solanum Lyratum InhibitsAnaphylactic Reaction and Suppresses the Expression of L- Histidine Decarboxylase mRNA

Abstract

We investigated the effect of aqueous extract of Soloanum lyratum THUNB. (Solanaceae) (SLAE) on anaphylactic reaction. The mast cell is widely thought to contribute to the acute changes associated with anaphylaxis. SLAE inhibited skin mast cells-mediated anaphylactic reaction activated by anti-dinitrophenyl (DNP) IgE. SLAE dose-dependently inhibited histamine release in mouse peritoneal mast cells activated by anti-DNP IgE or substance P. Substance P increased steady state levels of L-histidine decarboxylase (HDC) mRNA in mouse mastocytoma P-815 cells. Northern-blot analysis demonstrated that significantly reduced level of the mRNA of HDC was expressed in mast cells treated with SLAE, compared to that without SLAE. We conclude that SLAE directly affect IgE-mediated anaphylactic reaction and substance P-induced HDC mRNA over-expression.

Caspase and mitogen activated protein kinase pathways are involved in Solanum lyratum herba induced apoptosis

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Determination of arsenic species in Solanum Lyratum Thunb using capillary electrophoresis with inductively coupled plasma mass spectrometry

“…Solanum Lyratum Thunb (SLT) is a kind of anticancer Chinese herbal medicine and had such pharmacological functions as anti‐tumor, anti‐inflammatory, anti‐allergic, anti‐fungal, etc. . In recent years, there has been increasing interest worldwide in the use of Chinese herbal medicine for the prevention and treatment of various illnesses .…”

Comparative pharmacokinetics of chlorogenic acid after oral administration in rats

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