Comparative pharmacokinetics of chlorogenic acid after oral administration in rats

Abstract

The present study was aimed at the comparison of the pharmacokinetics of pure chlorogenic acid and extract of Solanum lyratum Thunb. The animals were allocated to two groups, and were administered chlorogenic acid or extract of S. lyratum Thunb. at a dose of 50.0 mg/kg orally. Blood samples were collected up to 8 h post-dosing. Plasma chlorogenic acid analyses were performed using an HPLC method with UV detector. The pharmacokinetic parameters were evaluated using non-compartmental assessment. Significant differences existed in the two groups for AUC0−t, AUC0−∞ and CLz/F. The reliable HPLC method was successfully applied to the determination of chlorogenic acid in rat plasma at dosage of 50.0 mg/kg.

Simultaneous determination of phenolic acids by UPLC–MS/MS in rat plasma and its application in pharmacokinetic study after oral administration of Flos Lonicerae preparations

“…Product A, B, C, D, E, F extracts were dissolved in saline to give the concentration of 50% (v/v) immediately prior to drug administration. The contents of neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, 3,5-dicaffeoylquinic acid and 3,4dicaffeoylquinic acid in product extracts respectively were 16 This validated method was applied to monitor the plasma concentrations of neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, 3,5-dicaffeoylquinic acid and 3,4-dicaffeoylquinic acid simultaneously following single oral administration of Flos Lonicerae preparations in rats.…”

“…There were several articles concerning the quantification of chlorogenic acid in plasma [9][10][11][12][13][14][15][16][17]. However, apart from chlorogenic acid, simultaneous pharmacokinetic studies of other phenolic acids have not been reported after oral administration of Flos Lonicerae preparations in rats, and very little attention has been devoted to the pharmacokinetic studies of these components.…”

“…However, apart from chlorogenic acid, simultaneous pharmacokinetic studies of other phenolic acids have not been reported after oral administration of Flos Lonicerae preparations in rats, and very little attention has been devoted to the pharmacokinetic studies of these components. In the previous pharmacokinetic studies of chlorogenic acid, its concentration in plasma was analyzed by high performance liquid chromatography (HPLC) with UV, ECD or MS [9][10][11][12][13][14][15][16][17]. However, Flos Lonicerae contains a series of phenolic acids that have isomer properties with different pharmacological activities [18] shown in Fig.…”

Caffeine and Chlorogenic Acids in Coffee and Effects on Selected Neurodegenerative Diseases

“…This protection is thought to be mediated via inhibiting down-regulation of anti-apoptotic proteins Bcl-2 and Bcl-X(L) and cleavage of caspase-3 and pro-poly (ADP-ribose) polymerase and additionally up regulation of the anti-oxidant enzyme NADPH quinine oxidoreductase 1 NQO1 [21][22][23] . Although characterization of chlorogenic acid and its metabolites is still an ongoing area of study, researchers found a plasma half-life of ~1.7 hours for chlorogenic acid in rats after oral administration 24 .…”

Chlorogenic Acid Inhibits the Replication and Viability of Enterovirus 71 In Vitro

“…Due to multiple viral species and serotype, antigenic variation, and genomic mutations, there is no proven effective treatment for EV71 infection [11]. CHA is the major active ingredient found in many traditional Chinese herbs and herbal medicine [12]. Structurally, CHA is an ester formed between caffeic acid and L-quinic acid.…”