<i>In vivo</i>and<i>in silico</i>investigations of the pegylated gold nanoparticle treatment of amyotrophic lateral sclerosis in mice

Vimal, Sunil Kumar; Cao, Hongyi; Dubey, Amit; Agrawal, Lokesh; Pathak, Nishit; Zuo, Hua; Kumar, Deepak; Bhattacharyya, Sanjib

doi:10.1039/d2nj00452f

Cited by 7 publications

(3 citation statements)

References 42 publications

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“…71,72 The preparation and optimization of this nanofluid cluster complex were meticulously executed, employing the default parameters established in previous research. 41,73 ■ ASSOCIATED CONTENT * sı Supporting Information…”

Section: Structural and Microstructural Characterizationmentioning

confidence: 99%

“…In our pursuit of investigating interactions, we computationally modeled Au–Pt–Pd trimetallic nanofluids within the 4–11 nm range. These nanofluids consisted of a cluster of face-centered-cubic Au, Pt, and Pd atoms, incorporating one gold, one platinum, and six palladium atoms. , The preparation and optimization of this nanofluid cluster complex were meticulously executed, employing the default parameters established in previous research. , …”

Section: Experimental Sectionmentioning

confidence: 99%

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Synergistic Activity of Noble Trimetallic Nanofluids: Unveiling Unprecedented Antimicrobial Potential and Computational Insights

Maddheshiya,

Kumar,

Tufail

et al. 2024

ACS Appl. Bio Mater.

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Nanofluids hold significant promise in diverse applications, particularly in biomedicine, where noble trimetallic nanofluids outperformed their monometallic counterparts. The composition, morphology, and size of these nanofluids play pivotal roles in their functionality. Controlled synthesis methods have garnered attention, focusing on precise morphology, content, biocompatibility, and versatile chemistry. Understanding how reaction parameters such as time, reducing agents, stabilizers, precursor concentration, temperature, and pH affect size and shape during synthesis is crucial. Trimetallic nanofluids, with their ideal composition, size, surface structure, and synergistic properties, are gaining traction in antimicrobial applications. These nanofluids were tested against seven microorganisms, demonstrating a heightened antimicrobial efficacy. Computational analyses, including molecular docking, dynamics, density functional theory (DFT), molecular electrostatic potential (MESP) analysis, and absorption, distribution, metabolism, elimination, and toxicology studies (ADMET) provided insights into binding interactions, energy, reactivity, and safety profiles, affirming the antimicrobial potential of trimetallic nanofluids. These findings emphasize the importance of controlled synthesis and computational validation in harnessing the unique properties of trimetallic nanofluids for biomedical applications.

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Section: Structural and Microstructural Characterizationmentioning

confidence: 99%

Section: Experimental Sectionmentioning

confidence: 99%

Synergistic Activity of Noble Trimetallic Nanofluids: Unveiling Unprecedented Antimicrobial Potential and Computational Insights

Maddheshiya,

Kumar,

Tufail

et al. 2024

ACS Appl. Bio Mater.

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“…PEG is a commonly used polymer and is considered a gold standard for polymer-based drug delivery, as it enhances the biocompatibility and hydrophilicity of inorganic nanomaterials [ 27 , 28 ]. The generalized structures of PEG-based nanohybrids are given in Figure 1 .…”

Section: Polyethylene Glycol-based Nanohybridsmentioning

confidence: 99%

Polymer-Based Hybrid Nanoarchitectures for Cancer Therapy Applications

et al. 2022

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Globally, cancer is affecting societies and is becoming an important cause of death. Chemotherapy can be highly effective, but it is associated with certain problems, such as undesired targeting and multidrug resistance. The other advanced therapies, such as gene therapy and peptide therapy, do not prove to be effective without a proper delivery medium. Polymer-based hybrid nanoarchitectures have enormous potential in drug delivery. The polymers used in these nanohybrids (NHs)provide them with their distinct properties and also enable the controlled release of the drugs. This review features the recent use of polymers in the preparation of different nanohybrids for cancer therapy published since 2015 in some reputed journals. The polymeric nanohybrids provide an advantage in drug delivery with the controlled and targeted delivery of a payload and the irradiation of cancer by chemotherapeutical and photodynamic therapy.

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Zingerone inhibits biofilm formation and enhances antibiotic efficacy against Salmonella biofilm

Kharga,

Dhar,

Kashyap

et al. 2023

World J Microbiol Biotechnol

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In vivoandin silicoinvestigations of the pegylated gold nanoparticle treatment of amyotrophic lateral sclerosis in mice

Abstract: Amyotrophic lateral sclerosis (ALS) is a lethal disease that involves progressive annihilation of motor neurons. In a preclinical setting, a sensitive functional test is required to detect the malfunctioning motor...

Cited by 7 publications

References 42 publications

Synergistic Activity of Noble Trimetallic Nanofluids: Unveiling Unprecedented Antimicrobial Potential and Computational Insights

Synergistic Activity of Noble Trimetallic Nanofluids: Unveiling Unprecedented Antimicrobial Potential and Computational Insights

Polymer-Based Hybrid Nanoarchitectures for Cancer Therapy Applications

Zingerone inhibits biofilm formation and enhances antibiotic efficacy against Salmonella biofilm

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