Zingerone inhibits biofilm formation and enhances antibiotic efficacy against Salmonella biofilm

Kharga, Kusum; Dhar, Irra; Kashyap, Shashank; Sengupta, Sounok; Kumar, Deepak; Kumar, Lokender

doi:10.1007/s11274-023-03716-y

Cited by 8 publications

(3 citation statements)

References 84 publications

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“…The swimming, twitching, and curling pilus movement phenotypes of EcN after OA intervention were tested using the method described by [ 28 , 29 , 30 ] and modified.…”

Section: Methodsmentioning

confidence: 99%

Oleanolic Acid Promotes the Formation of Probiotic Escherichia coli Nissle 1917 (EcN) Biofilm by Inhibiting Bacterial Motility

Liu,

Ran

et al. 2024

Microorganisms

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Probiotic biofilms have been beneficial in the fight against infections, restoring the equilibrium of the host’s gut microbiota, and enhancing host health. They are considered a novel strategy for probiotic gut colonization. In this case, we evaluated the effects of various active substances from traditional Chinese medicine on Escherichia coli Nissle 1917 (EcN) to determine if they promote biofilm formation. It was shown that 8–64 μg/mL of oleanolic acid increased the development of EcN biofilm. Additionally, we observed that oleanolic acid can effectively suppress biofilm formation in pathogenic bacteria such as Salmonella and Staphylococcus aureus. Next, we assessed the amount of EcN extracellular polysaccharides, the number of live bacteria, their metabolic activity, the hydrophobicity of their surface, and the shape of their biofilms using laser confocal microscopy. Through transcriptome analysis, a total of 349 differentially expressed genes were identified, comprising 134 upregulated and 215 downregulated genes. GO functional enrichment analysis and KEGG pathway enrichment analysis revealed that oleanolic acid functions are through the regulation of bacterial motility, the iron absorption system, the two-component system, and adhesion pathways. These findings suggest that the main effects of oleanolic acid are to prevent bacterial motility, increase initial adhesion, and encourage the development of EcN biofilms. In addition, oleanolic acid interacts with iron absorption to cooperatively control the production of EcN biofilms within an optimal concentration range. Taking these results together, this study suggests that oleanolic acid may enhance probiotic biofilm formation in the intestines, presenting new avenues for probiotic product development.

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“…The swimming, twitching, and curling pilus movement phenotypes of EcN after OA intervention were tested using the method described by [ 28 , 29 , 30 ] and modified.…”

Section: Methodsmentioning

confidence: 99%

Oleanolic Acid Promotes the Formation of Probiotic Escherichia coli Nissle 1917 (EcN) Biofilm by Inhibiting Bacterial Motility

Liu,

Ran

et al. 2024

Microorganisms

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“…Typhoid fever [42] Klebsiella pneumoniae COPD [43] Haemophilus influenza COPD [44] Fungi Aspergillus fumigatus Aspergillosis [45,46]…”

Section: Salmonellamentioning

confidence: 99%

“…15, x FOR PEER REVIEW 29 of42 248]. Specifically, Si et al constructed a microfluidic bronchial-airway-on-a-chip technology incorporating pulmonary endothelium and highly differentiated human bronchialairway epithelium.…”

mentioning

confidence: 99%

Nanotechnology-Based Drug Delivery Systems to Control Bacterial-Biofilm-Associated Lung Infections

Guo,

Mao,

Ran

et al. 2023

Pharmaceutics

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Airway mucus dysfunction and impaired immunological defenses are hallmarks of several lung diseases, including asthma, cystic fibrosis, and chronic obstructive pulmonary diseases, and are mostly causative factors in bacterial-biofilm-associated respiratory tract infections. Bacteria residing within the biofilm architecture pose a complex challenge in clinical settings due to their increased tolerance to currently available antibiotics and host immune responses, resulting in chronic infections with high recalcitrance and high rates of morbidity and mortality. To address these unmet clinical needs, potential anti-biofilm therapeutic strategies are being developed to effectively control bacterial biofilm. This review focuses on recent advances in the development and application of nanoparticulate drug delivery systems for the treatment of biofilm-associated respiratory tract infections, especially addressing the respiratory barriers of concern for biofilm accessibility and the various types of nanoparticles used to combat biofilms. Understanding the obstacles facing pulmonary drug delivery to bacterial biofilms and nanoparticle-based approaches to combatting biofilm may encourage researchers to explore promising treatment modalities for bacterial-biofilm-associated chronic lung infections.

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Cyclic di-peptide Cyclo (L-Phe-L-Pro) mitigates the quorum-sensing mediated virulence in Salmonella typhi and biofilm formation in poultry and plastic system

Jha,

Kumar,

Sivasankar

et al. 2024

Food Bioscience

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Zingerone inhibits biofilm formation and enhances antibiotic efficacy against Salmonella biofilm

Cited by 8 publications

References 84 publications

Oleanolic Acid Promotes the Formation of Probiotic Escherichia coli Nissle 1917 (EcN) Biofilm by Inhibiting Bacterial Motility

Oleanolic Acid Promotes the Formation of Probiotic Escherichia coli Nissle 1917 (EcN) Biofilm by Inhibiting Bacterial Motility

Nanotechnology-Based Drug Delivery Systems to Control Bacterial-Biofilm-Associated Lung Infections

Cyclic di-peptide Cyclo (L-Phe-L-Pro) mitigates the quorum-sensing mediated virulence in Salmonella typhi and biofilm formation in poultry and plastic system

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