Polymer-Based Hybrid Nanoarchitectures for Cancer Therapy Applications

Kumar, Arun; Sharipov, Mirkomil; Тураев, А. С.; Azizov, Shavkatjon; Azizov, Ismatdjan; Makhado, Edwin; Rahdar, Abbas; Kumar, Deepak; Pandey, Sadanand

doi:10.3390/polym14153027

Cited by 20 publications

(16 citation statements)

References 116 publications

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“…Meticulously controlled steps should be carried out for fabrication of polymeric nanoparticles, to obtain a homogeneous size of less than 200 nm. Using standard extrusion techniques, the particle size composition could be modified . When in vivo studies are conducted, the fate of the nanocarrier is determined by surface charge.…”

Section: Drug Delivery Changesmentioning

confidence: 99%

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Advances in Lung Cancer Treatment Using Nanomedicines

Sharma

Shambhwani²,

Pandey

et al. 2022

ACS Omega

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Carcinoma of the lungs is among the most menacing forms of malignancy and has a poor prognosis, with a low overall survival rate due to delayed detection and ineffectiveness of conventional therapy. Therefore, drug delivery strategies that may overcome undesired damage to healthy cells, boost therapeutic efficacy, and act as imaging tools are currently gaining much attention. Advances in material science have resulted in unique nanoscale-based theranostic agents, which provide renewed hope for patients suffering from lung cancer. Nanotechnology has vastly modified and upgraded the existing techniques, focusing primarily on increasing bioavailability and stability of anti-cancer drugs. Nanocarrier-based imaging systems as theranostic tools in the treatment of lung carcinoma have proven to possess considerable benefits, such as early detection and targeted therapeutic delivery for effectively treating lung cancer. Several variants of nano-drug delivery agents have been successfully studied for therapeutic applications, such as liposomes, dendrimers, polymeric nanoparticles, nanoemulsions, carbon nanotubes, gold nanoparticles, magnetic nanoparticles, solid lipid nanoparticles, hydrogels, and micelles. In this Review, we present a comprehensive outline on the various types of overexpressed receptors in lung cancer, as well as the various targeting approaches of nanoparticles.

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Section: Drug Delivery Changesmentioning

confidence: 99%

“…Using standard extrusion techniques, the particle size composition could be modified. 345 When in vivo studies are conducted, the fate of the nanocarrier is determined by surface charge. The zeta potential of nanoparticles has a significant impact on particle–particle interactions and aggregation tendencies.…”

Section: Drug Delivery Changesmentioning

confidence: 99%

Advances in Lung Cancer Treatment Using Nanomedicines

Sharma

Shambhwani²,

Pandey

et al. 2022

ACS Omega

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“…Drug delivery systems that are engineered at the nanoscale have been extensively studied and are by far the most advanced technology in the field of nanoparticle applications due to their potential advantages, such as the ability to modify physical properties such as solubility, release profiles, diffusion, bioavailability, and immunogenicity [ 77 , 78 ]. The delivery of engineering drug systems either targets a specific site or injects therapeutic agents into the site in a controlled manner [ 79 ]. Figure 2 shows the efficacy of a chemotherapeutic drug when it is encapsulated in green nanoparticles.…”

Section: Targeted Drug Delivery Using Phytogenic Nanoparticlesmentioning

confidence: 99%

Bio-Inspired Smart Nanoparticles in Enhanced Cancer Theranostics and Targeted Drug Delivery

Gulia

James

Pandey

et al. 2022

JFB

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Globally, a significant portion of deaths are caused by cancer.Compared with traditional treatment, nanotechnology offers new therapeutic options for cancer due to its ability to selectively target and control drug release. Among the various routes of nanoparticle synthesis, plants have gained significant recognition. The tremendous potential of medicinal plants in anticancer treatments calls for a comprehensive review of existing studies on plant-based nanoparticles. The study examined various metallic nanoparticles obtained by green synthesis using medicinal plants. Plants contain biomolecules, secondary metabolites, and coenzymes that facilitate the reduction of metal ions into nanoparticles. These nanoparticles are believed to be potential antioxidants and cancer-fighting agents. This review aims at the futuristic intuitions of biosynthesis and applications of plant-based nanoparticles in cancer theranostics.

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“…Bone marrow transplantation is replacing of damaged or diseased bone marrow. Surgery removes cancerous tumors [ 11 , 12 ]. In the traditional medicinal system, various medicinal plants have been reported to cure or treat infectious diseases, atherosclerosis, diabetes, cancer, etc.…”

Section: Introductionmentioning

confidence: 99%

A Review of Medicinal Plants of the Himalayas with Anti-Proliferative Activity for the Treatment of Various Cancers

Regassa

Sourirajan

Kumar

et al. 2022

Cancers

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Cancer is a serious and significantly progressive disease. Next to cardiovascular disease, cancer has become the most common cause of mortality in the entire world. Several factors, such as environmental factors, habitual activities, genetic factors, etc., are responsible for cancer. Many cancer patients seek alternative and/or complementary treatments because of the high death rate linked with cancer and the adverse side effects of chemotherapy and radiation therapy. Traditional medicine has a long history that begins with the hunt for botanicals to heal various diseases, including cancer. In the traditional medicinal system, several plants used to treat diseases have many bioactive compounds with curative capability, thereby also helping in disease prevention. Plants also significantly contributed to the modern pharmaceutical industry throughout the world. In the present review, we have listed 33 medicinal plants with active and significant anticancer activity, as well as their anticancer compounds. This article will provide a basic set of information for researchers interested in developing a safe and nontoxic active medicinal plant-based treatment for cancer. The research will give a scientific foundation for the traditional usage of these medicinal herbs to treat cancer.

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Polymer-Based Hybrid Nanoarchitectures for Cancer Therapy Applications

Cited by 20 publications

References 116 publications

Advances in Lung Cancer Treatment Using Nanomedicines

Advances in Lung Cancer Treatment Using Nanomedicines

Bio-Inspired Smart Nanoparticles in Enhanced Cancer Theranostics and Targeted Drug Delivery

A Review of Medicinal Plants of the Himalayas with Anti-Proliferative Activity for the Treatment of Various Cancers

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