<i>Hibiscus sabdariffa</i> ethanolic extract modulates adipokine levels, decreases visceral fat and improves glycemic profile in high-fat/sugar diet-induced obese rats

Dentz, Karla Eduarda Von; Silva, Bianca S.; Queiroz, Eveline Aparecida Isquierdo Fonseca de; Bomfim, Gisele Facholi; Nascimento, André Ferreira do; Sugizaki, Mário Mateus; Luvizotto, Renata de Azevedo Melo

doi:10.1108/nfs-03-2020-0092

Cited by 9 publications

(13 citation statements)

References 35 publications

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“…Other authors have also reported the effect of Hibiscus and Lemon verbena on some of the analyzed hormones, such as Hibiscus on leptin expression [ 27 ], or Lemon verbena activating AMPK [ 28 ], which is known to have an important role in controlling appetite in the hypothalamus [ 29 ]. Furthermore, high polyphenolic intake has been associated with weight loss, particularly anthocyanins and flavonols [ 30 ].…”

Section: Methodsmentioning

confidence: 99%

Effectiveness of a polyphenolic extract (Lippia citriodora and Hibiscus sabdariffa) on appetite regulation in overweight and obese grade I population: an 8-week randomized, double-blind, cross-over, placebo-controlled trial

et al. 2021

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Introduction Polyphenols have shown capacity to improve appetite sensation, leading to enhanced control of body weight. However, despite being related with hunger-related hormones, metabolic and mechanism are not well known. Methods The effectiveness of a nutraceutical composed of extract to Lippia citriodora and Hibiscus sabdarrifa (Lc-Hs) for controlling satiety and hunger was analyzed in a cross-over, placebo-controlled (Pla) clinical intervention. The study was divided in two 60-day periods separated by 30-day length wash-out period. At the end of each period, overweight and obese subjects (n = 33; age = 33.76 ± 12.23; BMI = 28.20 kg/m2 ± 2.47; fat mass 30.65 ± 8.39%; both sexes were proposed to eat an ad-libitum meal. Meanwhile, appetite sensation was determined by visual analog scales at different times. Moreover, blood extraction was performed to determine biochemical parameters (lipid and glucidic profile and safety parameters) and to evaluate hunger-related hormones (insulin, leptin, ghrelin, adiponectin, GLP-1 and peptide YY). Results A decrease in appetite sensation was observed in Lc-Hs treatment, showing higher satiety quotient (Pla = 3.36 ± 2.33%mm/kcal; Lc-Hs = 5.53 ± 2.91%mm/kcal; p < 0.0001). Area under the curve was higher in Pla compared to Lc-Hs during the test, from baseline to minute 240 (240 (Pla 9136.65 ± 2261.46% x min−1; Lc-Hs 8279.73 ± 2745.71% x min−1; p < 0.014). Energy consumption was lower for subjects treated with Lc-Hs (774.44 ± 247.77 kcal) compared to those treated with Pla (849.52 ± 246.54 kcal) (p < 0.004). Leptin values varied from baseline (Pla 12.36 ± 1.98 ng/mL; Lc-Hs 13.13 ± 1.99 ng/mL) to the end of the study (Pla 12.60 ± 2.02 ng/mL; Lc-Hs 12.06 ± 2.05 ng/mL; p < 0.047). GLP-1 values varied (p < 0.001) in Lc-Hs treatment from baseline (4.34 ± 0.49 ng/mL) to the end of the study (3.23 ± 0.52 ng/mL). Conclusion The supplementation with the Lc-Hs extract decreases appetite sensation in overweight and obese population, reducing calorie intake after an ad-libitum meal. Due to variation on hunger-related hormones and the relationship between satiety feeling, it would be interesting to develop future research focused on the variation of the hormones themselves.

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Section: Methodsmentioning

confidence: 99%

Effectiveness of a polyphenolic extract (Lippia citriodora and Hibiscus sabdariffa) on appetite regulation in overweight and obese grade I population: an 8-week randomized, double-blind, cross-over, placebo-controlled trial

et al. 2021

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“…Accordingly, recent research seems to have granted special interest for the search of effective natural glucosidase and lipase inhibitors (Hamden et al, 2017). Previous research studies have shown that medicinal plants exhibited pronounced inhibitory effects towards the activities of a-amylase, lipase and inflammation (Kang et al, 2015;Ghasemian et al, 2016;Von Dentz, et al, 2020;Joshi et al, 2018;Feng et al, 2020;Mohamed et al, 2020;Tiss et al, 2020). In fact, Plants are a source of bioactive secondary metabolites such as glycosides, saponins, flavonoids, steroids, tannins, alkaloids and terpenes, which act as strong antioxidant to protect body from oxidative damage (Upreti et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Ephedra alata extracts exerts anti-obesity, anti-hyperglycemia, anti-antipyretic and analgesic effects

Tiss

Souiy

Achour

et al. 2021

NFS

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Purpose This study paper aims to evaluate the Phytochemical Composition, anti-obesity, anti-antipyretic and analgesic effect of Ephedra alata (Ea) extracts. Design/methodology/approach Obesity was induced in male Wistar rats through a high-fat/fructose diet (HF/FD). Control rats received a standard diet. Findings Results of this study showed that the Ea methanol extract (MEEa) exhibited a prominent selective inhibitory effect against lipase activity (IC50 = 1.29 mg/ml) as compared to water and ethyl acetate extracts (with IC50 = 1.63 and 1.89, respectively). Also, MEEa exert antipyretic and analgesic activities. In high-fat-high-fructose diet rats, the administration of MEEa inhibited lipase activity in the intestine, pancreas and serum by 53%, 40% and 53%, respectively. It was found to significantly decrease body weight by 20% (p = 0.09) and delay the absorption of triglycerides (TG), total cholesterol (TC), LDL-cholesterol (LDL-C) and increase HDL-cholesterol (HDL-C). In addition, MEEa efficiently decreased a-amylase activity in the intestine, pancreas and serum by 43%, 26% and 46%, respectively, and blood glucose level by 35% (p = 0.06). Originality/value To the best of the authors’ knowledge, this study demonstrates for the first time that MEEa are efficient in preventing obesity and hyperglycemia, pain and fever.

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“…11 High-calorie-diet-induced obesity resulted in increased weight and body fat corroborating other studies conducted in the same laboratory. 15 The ET protocols used in this study were effective in reducing body weight and fat. Body weight decreased 10% and 25% in normal-weight and obese rats after 60 days of ET, respectively.…”

Section: Discussionmentioning

confidence: 81%

“…The ET protocol was established for each group according to their clinical conditions. 15 In a pilot study, obese rats could not perform interval training due to excess weight. Thus, moderate intensity AT was used for them (50% of Speed max in the MPET).…”

Section: Discussionmentioning

confidence: 99%

“…Hs supplementation reduced body fat in normal-weight and obese rats corroborating with previous findings. 15 interleukin (IL The effect of Hs on body fat in obese people is demonstrated in the meta-analysis by Zhang et al, 21 which showed that the use of Hs as a herbal treatment reduced cholesterol levels in patients with metabolic syndrome. A study by Diez-Echave et al 22 showed that Hs treatment with doses one, 10, and 25 mg/kg/d for six weeks decreased fat content in obesity induced by a hypercaloric diet in obese rats.…”

Section: Discussionmentioning

confidence: 99%

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Hibiscus Increases Functional Capacity and the Anti-Obesity Effect in Trained Obese Rats

Oliveira

Arsa

Giordani

et al. 2023

Rev Bras Med Esporte

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Introduction Hibiscus sabdariffa (Hs) has been widely used for weight loss and in the fight against obesity-associated comorbidities. Objective To evaluate the effects of Hs and physical training on the functional capacity of normal-weight and obese rats. Methods Wistar rats were distributed into eight experimental groups: control (C, n = 8) , Hibiscus Sabdariffa (Hs, n = 8), high-intensity interval training (IT, n = 8), high-intensity interval training + Hibiscus Sabdariffa (ITHs, n = 8), obese (O, n = 8), obese + continuous aerobic training (OAT, n = 8), obese + Hibiscus Sabdariffa (OHs, n = 8), , and obese + continuous aerobic training + Hibiscus Sabdariffa (OATHs, n = 8). Hibiscus Sabdariffa extract was administered for 60 days in a dose of 150 mg/kg of body weight. The maximum progressive effort test (MPET) was performed on a treadmill at the beginning and end of the study. The variables analyzed were maximum speed Vmáx time, and distance covered. Lactate was measured immediately after the MPET. Functional capacity was evaluated by the distance/adiposity index. The ANOVA with Bonferroni post hoc and Pearson’s correlation tests were used at a 5% significance level. Results After both types of training, moderate-intensity continuous and high-intensity interval performed on the treadmill, final body weight, weight gain, and the adiposity index decreased, and Vmax, time, and distance covered in the MPET increased, in addition to an improvement in functional capacity. Hs supplementation reduced the adiposity index in normal-weight and obese rats. Hs associated with aerobic training reduced final body weight and increased functional capacity. Conclusion Hs supplementation promoted a reduction in the adiposity index in normal-weight and obese rats and an increase in the functional capacity of trained obese rats. Level of Evidence III; Therapeutic Studies - Outcome Investigation. Case study – control.

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Hibiscus sabdariffa ethanolic extract modulates adipokine levels, decreases visceral fat and improves glycemic profile in high-fat/sugar diet-induced obese rats

Cited by 9 publications

References 35 publications

Effectiveness of a polyphenolic extract (Lippia citriodora and Hibiscus sabdariffa) on appetite regulation in overweight and obese grade I population: an 8-week randomized, double-blind, cross-over, placebo-controlled trial

Effectiveness of a polyphenolic extract (Lippia citriodora and Hibiscus sabdariffa) on appetite regulation in overweight and obese grade I population: an 8-week randomized, double-blind, cross-over, placebo-controlled trial

Ephedra alata extracts exerts anti-obesity, anti-hyperglycemia, anti-antipyretic and analgesic effects

Hibiscus Increases Functional Capacity and the Anti-Obesity Effect in Trained Obese Rats

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